Association between plasma lysophosphatidic acid levels and bronchopulmonary dysplasia in extremely preterm infants: A prospective study

Association between plasma lysophosphatidic acid levels and bronchopulmonary dysplasia in extremely preterm infants: A prospective study

BackgroundLysophosphatidic acid (LPA) is implicated in bronchopulmonary dysplasia (BPD) pathogenesis, but clinical evidence is lacking. This study aimed to investigate LPA levels in preterm infants with and without BPD and explore LPA as a biomarker for predicting BPD occurrence.MethodsPremature inf...

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Veröffentlicht in:Pediatric pulmonology 2023-12, Vol.58 (12), p.3516-3522
Hauptverfasser: Li, Huitao, Huang, Zilu, Yang, Chuanzhong, Han, Dongshan, Wang, Xuan, Qiu, Xiaomei, Zhang, Zhiwei, Chen, Xueyu
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Lung diseases
Newborn babies
Plasma
Premature babies
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container_end_page 3522
container_issue 12
container_start_page 3516
container_title Pediatric pulmonology
container_volume 58
creator Li, Huitao
Huang, Zilu
Yang, Chuanzhong
Han, Dongshan
Wang, Xuan
Qiu, Xiaomei
Zhang, Zhiwei
Chen, Xueyu
description BackgroundLysophosphatidic acid (LPA) is implicated in bronchopulmonary dysplasia (BPD) pathogenesis, but clinical evidence is lacking. This study aimed to investigate LPA levels in preterm infants with and without BPD and explore LPA as a biomarker for predicting BPD occurrence.MethodsPremature infants with a gestational age of
doi_str_mv 10.1002/ppul.26685
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This study aimed to investigate LPA levels in preterm infants with and without BPD and explore LPA as a biomarker for predicting BPD occurrence.MethodsPremature infants with a gestational age of &lt;28 weeks or a birth weight of &lt;1000 g were enrolled. Blood samples were collected at postnatal day (PD) 7, 28, and postmenstrual age (PMA) 36 weeks, and plasma LPA levels were measured using a commercial ELISA kit. Receiver operating characteristic curve (ROC) curve analysis determined the PD 28 cutoff for LPA, and multivariable regression analyzed LPA's independent contribution to BPD and exploratory outcomes.ResultAmong the 91 infants enrolled in this study, 35 were classified into the non‐BPD group and 56 into the BPD group. Infants with BPD had higher plasma LPA levels at PD 28 (6.467 vs. 4.226 μg/mL, p = 0.034) and PMA 36 weeks (2.330 vs. 1.636 μg/mL, p = 0.001). PD 28 LPA level of 6.132 μg/mL was the cutoff for predicting BPD development. Higher PD 28 LPA levels (≥6.132 μg/mL) independently associated with BPD occurrence (OR 3.307, 95% CI 1.032–10.597, p = 0.044). Higher LPA levels correlated with longer oxygen therapy durations [regression coefficients (β) 0.147, 95% CI 0.643–16.133, p = .034].ConclusionsInfants with BPD had higher plasma LPA levels at PD 28 and PMA 36 weeks. Higher PD 28 LPA levels independently associated with an increased BPD risk.</description><identifier>ISSN: 8755-6863</identifier><identifier>ISSN: 1099-0496</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.26685</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Lung diseases ; Newborn babies ; Plasma ; Premature babies</subject><ispartof>Pediatric pulmonology, 2023-12, Vol.58 (12), p.3516-3522</ispartof><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-87d040e5b822ee1b53c3c184eb90a8f809d640cc3eef9b9d7e089b6d8f9e81fd3</citedby><cites>FETCH-LOGICAL-c328t-87d040e5b822ee1b53c3c184eb90a8f809d640cc3eef9b9d7e089b6d8f9e81fd3</cites><orcidid>0000-0002-7066-0501</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Li, Huitao</creatorcontrib><creatorcontrib>Huang, Zilu</creatorcontrib><creatorcontrib>Yang, Chuanzhong</creatorcontrib><creatorcontrib>Han, Dongshan</creatorcontrib><creatorcontrib>Wang, Xuan</creatorcontrib><creatorcontrib>Qiu, Xiaomei</creatorcontrib><creatorcontrib>Zhang, Zhiwei</creatorcontrib><creatorcontrib>Chen, Xueyu</creatorcontrib><title>Association between plasma lysophosphatidic acid levels and bronchopulmonary dysplasia in extremely preterm infants: A prospective study</title><title>Pediatric pulmonology</title><description>BackgroundLysophosphatidic acid (LPA) is implicated in bronchopulmonary dysplasia (BPD) pathogenesis, but clinical evidence is lacking. This study aimed to investigate LPA levels in preterm infants with and without BPD and explore LPA as a biomarker for predicting BPD occurrence.MethodsPremature infants with a gestational age of &lt;28 weeks or a birth weight of &lt;1000 g were enrolled. Blood samples were collected at postnatal day (PD) 7, 28, and postmenstrual age (PMA) 36 weeks, and plasma LPA levels were measured using a commercial ELISA kit. Receiver operating characteristic curve (ROC) curve analysis determined the PD 28 cutoff for LPA, and multivariable regression analyzed LPA's independent contribution to BPD and exploratory outcomes.ResultAmong the 91 infants enrolled in this study, 35 were classified into the non‐BPD group and 56 into the BPD group. Infants with BPD had higher plasma LPA levels at PD 28 (6.467 vs. 4.226 μg/mL, p = 0.034) and PMA 36 weeks (2.330 vs. 1.636 μg/mL, p = 0.001). PD 28 LPA level of 6.132 μg/mL was the cutoff for predicting BPD development. Higher PD 28 LPA levels (≥6.132 μg/mL) independently associated with BPD occurrence (OR 3.307, 95% CI 1.032–10.597, p = 0.044). Higher LPA levels correlated with longer oxygen therapy durations [regression coefficients (β) 0.147, 95% CI 0.643–16.133, p = .034].ConclusionsInfants with BPD had higher plasma LPA levels at PD 28 and PMA 36 weeks. Higher PD 28 LPA levels independently associated with an increased BPD risk.</description><subject>Lung diseases</subject><subject>Newborn babies</subject><subject>Plasma</subject><subject>Premature babies</subject><issn>8755-6863</issn><issn>1099-0496</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkU1LxDAQhoMouH5c_AUBLyJUk6bNJt4W8QsEL3ouaTJls6RJbVK1_8Cfbdb15Glg5pmZd-ZF6IySK0pIeT0Mk7sqORf1HlpQImVBKsn30UIs67rggrNDdBTjhpBck3SBvlcxBm1VssHjFtIngMeDU7FX2M0xDOsQh3UuG6ux0tZgBx_gIlbe4HYMXq9D3tkHr8YZmzlue63C1mP4SiP04GY8jJBg7HOyUz7FG7zKqTwXdLIfgGOazHyCDjrlIpz-xWP0dn_3evtYPL88PN2ungvNSpEKsTSkIlC3oiwBaFszzTQVFbSSKNEJIg2viNYMoJOtNEsgQrbciE6CoJ1hx-hiNzcreJ8gpqa3UYNzykOYYlMKXi9FxbnM6Pk_dBOm0Wd1mZJU1jVnLFOXO0rnk-IIXTOMts_faChptqY0W1OaX1PYD-OohFc</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Li, Huitao</creator><creator>Huang, Zilu</creator><creator>Yang, Chuanzhong</creator><creator>Han, Dongshan</creator><creator>Wang, Xuan</creator><creator>Qiu, Xiaomei</creator><creator>Zhang, Zhiwei</creator><creator>Chen, Xueyu</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7066-0501</orcidid></search><sort><creationdate>20231201</creationdate><title>Association between plasma lysophosphatidic acid levels and bronchopulmonary dysplasia in extremely preterm infants: A prospective study</title><author>Li, Huitao ; Huang, Zilu ; Yang, Chuanzhong ; Han, Dongshan ; Wang, Xuan ; Qiu, Xiaomei ; Zhang, Zhiwei ; Chen, Xueyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-87d040e5b822ee1b53c3c184eb90a8f809d640cc3eef9b9d7e089b6d8f9e81fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Lung diseases</topic><topic>Newborn babies</topic><topic>Plasma</topic><topic>Premature babies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Huitao</creatorcontrib><creatorcontrib>Huang, Zilu</creatorcontrib><creatorcontrib>Yang, Chuanzhong</creatorcontrib><creatorcontrib>Han, Dongshan</creatorcontrib><creatorcontrib>Wang, Xuan</creatorcontrib><creatorcontrib>Qiu, Xiaomei</creatorcontrib><creatorcontrib>Zhang, Zhiwei</creatorcontrib><creatorcontrib>Chen, Xueyu</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Huitao</au><au>Huang, Zilu</au><au>Yang, Chuanzhong</au><au>Han, Dongshan</au><au>Wang, Xuan</au><au>Qiu, Xiaomei</au><au>Zhang, Zhiwei</au><au>Chen, Xueyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between plasma lysophosphatidic acid levels and bronchopulmonary dysplasia in extremely preterm infants: A prospective study</atitle><jtitle>Pediatric pulmonology</jtitle><date>2023-12-01</date><risdate>2023</risdate><volume>58</volume><issue>12</issue><spage>3516</spage><epage>3522</epage><pages>3516-3522</pages><issn>8755-6863</issn><issn>1099-0496</issn><eissn>1099-0496</eissn><abstract>BackgroundLysophosphatidic acid (LPA) is implicated in bronchopulmonary dysplasia (BPD) pathogenesis, but clinical evidence is lacking. This study aimed to investigate LPA levels in preterm infants with and without BPD and explore LPA as a biomarker for predicting BPD occurrence.MethodsPremature infants with a gestational age of &lt;28 weeks or a birth weight of &lt;1000 g were enrolled. Blood samples were collected at postnatal day (PD) 7, 28, and postmenstrual age (PMA) 36 weeks, and plasma LPA levels were measured using a commercial ELISA kit. Receiver operating characteristic curve (ROC) curve analysis determined the PD 28 cutoff for LPA, and multivariable regression analyzed LPA's independent contribution to BPD and exploratory outcomes.ResultAmong the 91 infants enrolled in this study, 35 were classified into the non‐BPD group and 56 into the BPD group. Infants with BPD had higher plasma LPA levels at PD 28 (6.467 vs. 4.226 μg/mL, p = 0.034) and PMA 36 weeks (2.330 vs. 1.636 μg/mL, p = 0.001). PD 28 LPA level of 6.132 μg/mL was the cutoff for predicting BPD development. Higher PD 28 LPA levels (≥6.132 μg/mL) independently associated with BPD occurrence (OR 3.307, 95% CI 1.032–10.597, p = 0.044). Higher LPA levels correlated with longer oxygen therapy durations [regression coefficients (β) 0.147, 95% CI 0.643–16.133, p = .034].ConclusionsInfants with BPD had higher plasma LPA levels at PD 28 and PMA 36 weeks. Higher PD 28 LPA levels independently associated with an increased BPD risk.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ppul.26685</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7066-0501</orcidid><oa>free_for_read</oa></addata></record>
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subjects Lung diseases
Newborn babies
Plasma
Premature babies
title Association between plasma lysophosphatidic acid levels and bronchopulmonary dysplasia in extremely preterm infants: A prospective study
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