Presynaptic Ube3a E3 ligase promotes synapse elimination through down-regulation of BMP signaling

Inactivation of the ubiquitin ligase Ube3a causes the developmental disorder Angelman syndrome, whereas increased Ube3a dosage is associated with autism spectrum disorders. Despite the enriched localization of Ube3a in the axon terminals including presynapses, little is known about the presynaptic f...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Science (American Association for the Advancement of Science) 2023-09, Vol.381 (6663), p.1197-1205
Hauptverfasser:	Furusawa, Kotaro, Ishii, Kenichi, Tsuji, Masato, Tokumitsu, Nagomi, Hasegawa, Eri, Emoto, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Angelman's syndrome Autism Defects Disorders Inactivation Localization Neurodevelopmental disorders Presynapse Synapse elimination Synapses Synaptogenesis Ubiquitin-protein ligase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!