The experience of diagnosis and treatment for TAFRO syndrome
Early identification, diagnosis and treatment of TAFRO syndrome are very importants. We retrospectively analysed 6 patients with TAFRO syndrome. Their clinical manifestations, treatment methods, survival and other aspects were summarized. All patients were pathologically diagnosed with Castleman’s d...
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Veröffentlicht in: | Annals of hematology 2023-12, Vol.102 (12), p.3515-3520 |
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container_title | Annals of hematology |
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creator | Wu, Xiaolong Zhang, Xudong Qian, Siyu Shi, Cunzhen Li, Xin Feng, Xiaoyan Zhu, Linan Ge, Jingjing Li, Zhaoming Zhang, Mingzhi |
description | Early identification, diagnosis and treatment of TAFRO syndrome are very importants. We retrospectively analysed 6 patients with TAFRO syndrome. Their clinical manifestations, treatment methods, survival and other aspects were summarized. All patients were pathologically diagnosed with Castleman’s disease, with fever, an inflammatory storm state and varying degrees of anasarca. All patients received steroid therapy; four of them also received chemotherapy, and 1 received rituximab. Of the 3 patients with severe disease, only 1 patient who received the recommended dose of glucocorticoids survived. Early administration of glucocorticoids can improve the prognosis, especially in patients with severe disease, and adequate glucocorticoids are important. |
doi_str_mv | 10.1007/s00277-023-05435-8 |
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We retrospectively analysed 6 patients with TAFRO syndrome. Their clinical manifestations, treatment methods, survival and other aspects were summarized. All patients were pathologically diagnosed with Castleman’s disease, with fever, an inflammatory storm state and varying degrees of anasarca. All patients received steroid therapy; four of them also received chemotherapy, and 1 received rituximab. Of the 3 patients with severe disease, only 1 patient who received the recommended dose of glucocorticoids survived. Early administration of glucocorticoids can improve the prognosis, especially in patients with severe disease, and adequate glucocorticoids are important.</description><identifier>ISSN: 0939-5555</identifier><identifier>ISSN: 1432-0584</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-023-05435-8</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anemia ; Ascites ; Biopsy ; Bone marrow ; Edema ; Fever ; Hematology ; Hematuria ; Inflammation ; Lymphatic system ; Medical diagnosis ; Medical prognosis ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Patients ; Phosphatase ; Pleural effusion ; Thrombocytopenia</subject><ispartof>Annals of hematology, 2023-12, Vol.102 (12), p.3515-3520</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. 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We retrospectively analysed 6 patients with TAFRO syndrome. Their clinical manifestations, treatment methods, survival and other aspects were summarized. All patients were pathologically diagnosed with Castleman’s disease, with fever, an inflammatory storm state and varying degrees of anasarca. All patients received steroid therapy; four of them also received chemotherapy, and 1 received rituximab. Of the 3 patients with severe disease, only 1 patient who received the recommended dose of glucocorticoids survived. Early administration of glucocorticoids can improve the prognosis, especially in patients with severe disease, and adequate glucocorticoids are important.</description><subject>Anemia</subject><subject>Ascites</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Edema</subject><subject>Fever</subject><subject>Hematology</subject><subject>Hematuria</subject><subject>Inflammation</subject><subject>Lymphatic system</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Phosphatase</subject><subject>Pleural effusion</subject><subject>Thrombocytopenia</subject><issn>0939-5555</issn><issn>1432-0584</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEFLAzEUhIMoWKt_wFPAi5fVl2SzScBLKVaFQkHqOcTdt3VLm9RkC_rvTV1B8OC7PAa-GYYh5JLBDQNQtwmAK1UAFwXIUshCH5ERKwXPUpfHZARGmELmOyVnKa0BGNclH5G75RtS_Nhh7NDXSENLm86tfEhdos43tI_o-i36nrYh0uVk9ryg6dM3MWzxnJy0bpPw4uePycvsfjl9LOaLh6fpZF7UQvK-MLlaA6bRrhYCkUMWxgmDrxUoYwAqVjOjZcMc1xpUU0mhtGgBJW9E5cSYXA-5uxje95h6u-1SjZuN8xj2yXJdSaWZEiqjV3_QddhHn9tlSutKaV7qTPGBqmNIKWJrd7HbuvhpGdjDoHYY1OZB7feg9mASgyll2K8w_kb_4_oCy7V1ww</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Wu, Xiaolong</creator><creator>Zhang, Xudong</creator><creator>Qian, Siyu</creator><creator>Shi, Cunzhen</creator><creator>Li, Xin</creator><creator>Feng, Xiaoyan</creator><creator>Zhu, Linan</creator><creator>Ge, Jingjing</creator><creator>Li, Zhaoming</creator><creator>Zhang, Mingzhi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3581-551X</orcidid></search><sort><creationdate>20231201</creationdate><title>The experience of diagnosis and treatment for TAFRO syndrome</title><author>Wu, Xiaolong ; Zhang, Xudong ; Qian, Siyu ; Shi, Cunzhen ; Li, Xin ; Feng, Xiaoyan ; Zhu, Linan ; Ge, Jingjing ; Li, Zhaoming ; Zhang, Mingzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-9277d09d8ac33ee20d099a39eb607990061c1985d1a28807d653783f0e52d36a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anemia</topic><topic>Ascites</topic><topic>Biopsy</topic><topic>Bone marrow</topic><topic>Edema</topic><topic>Fever</topic><topic>Hematology</topic><topic>Hematuria</topic><topic>Inflammation</topic><topic>Lymphatic system</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Phosphatase</topic><topic>Pleural effusion</topic><topic>Thrombocytopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xiaolong</creatorcontrib><creatorcontrib>Zhang, Xudong</creatorcontrib><creatorcontrib>Qian, Siyu</creatorcontrib><creatorcontrib>Shi, Cunzhen</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Feng, Xiaoyan</creatorcontrib><creatorcontrib>Zhu, Linan</creatorcontrib><creatorcontrib>Ge, Jingjing</creatorcontrib><creatorcontrib>Li, Zhaoming</creatorcontrib><creatorcontrib>Zhang, Mingzhi</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Xiaolong</au><au>Zhang, Xudong</au><au>Qian, Siyu</au><au>Shi, Cunzhen</au><au>Li, Xin</au><au>Feng, Xiaoyan</au><au>Zhu, Linan</au><au>Ge, Jingjing</au><au>Li, Zhaoming</au><au>Zhang, Mingzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The experience of diagnosis and treatment for TAFRO syndrome</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>102</volume><issue>12</issue><spage>3515</spage><epage>3520</epage><pages>3515-3520</pages><issn>0939-5555</issn><issn>1432-0584</issn><eissn>1432-0584</eissn><abstract>Early identification, diagnosis and treatment of TAFRO syndrome are very importants. 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subjects | Anemia Ascites Biopsy Bone marrow Edema Fever Hematology Hematuria Inflammation Lymphatic system Medical diagnosis Medical prognosis Medicine Medicine & Public Health Oncology Original Article Patients Phosphatase Pleural effusion Thrombocytopenia |
title | The experience of diagnosis and treatment for TAFRO syndrome |
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