Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3
Background Myocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle cell disease. Objective In this study, cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease were evaluated using card...
Gespeichert in:
| Veröffentlicht in: | Pediatric radiology 2023-11, Vol.53 (12), p.2515-2527 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2527 |
|---|---|
| container_issue | 12 |
| container_start_page | 2515 |
| container_title | Pediatric radiology |
| container_volume | 53 |
| creator | Wagdy, Reham Fathy, Alaa Elnekidy, Abdelaziz Salaheldin, Geylan Nazir, Hanan Fahmy, Rana Elkafrawy, Hagar Elkafrawy, Fatma |
| description | Background
Myocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle cell disease.
Objective
In this study, cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease were evaluated using cardiac magnetic resonance imaging (MRI), tissue Doppler echocardiography and serum galectin-3.
Materials and methods
The study included 34 children with sickle cell disease who were compared with a similar number of healthy controls. Cardiac MRI was used to evaluate late gadolinium enhancement, native T1 mapping, extracellular volume, and T2* for estimation of iron load. Cardiac function and myocardial performance index (MPI, evaluated by tissue Doppler echocardiography) and serum galectin-3 were compared to controls.
Results
The mean age of the included patients was 13.3 ± 3.2 years. Myocardial iron load by T2* was normal. The mean level of extracellular volume (35.41 ± 5.02%) was significantly associated with the frequency of vaso-occlusive crises (
P
= 0.017) and negatively correlated with hemoglobin levels (
P
= 0.005). Galectin-3 levels were significantly higher among cases than controls (
P
=
0.00)
, at a cutoff value on the receiver operating characteristic curve of 6.5 ng/ml, sensitivity of 82.5% and specificity of 72.8%. The extracellular volume was significantly higher in cases, with a MPI > 0.4.
Conclusion
Diffuse interstitial myocardial fibrosis can be detected early in children with sickle cell disease using T1 mapping and is associated with a high frequency of vaso-occlusive crisis. MPI of the left ventricle and serum galectin-3 are recommended screening tools for subclinical cardiac abnormalities.
Graphical abstract |
| doi_str_mv | 10.1007/s00247-023-05750-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2865780008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2887707105</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-27ec56d23cbefd235aedf589862c9c92515a0647c319a268980d5ef04da55b583</originalsourceid><addsrcrecordid>eNp9kctu1TAQhiMEEqXwAqwssWHRFF_iOFmiqlykSmxgbc2ZTHJcfJyDJwH1nXhIfBpEEQtWM_J8_4xn_qp6qeSlktK9YSl142qpTS2ts7LWj6oz1Rhdq77vHv-VP62eMd9KKY1V5qz6ef0d4gpLmJOYR4GQhwAoxrDLMwcWkAbB6w5jSAEh_gFwD2kiFiGVNMQhUxI_wrIXHPBrJIEUoxgCEzCJlUOaxAGmREtAkYnnBAlJhPJWSheCcD_ft56nDMf93cU2mPJ6EBNEwiWk2jyvnowQmV78jufVl3fXn68-1Def3n-8entTo2ncUmtHaNtBG9zRWIIFGkbb9V2rscdeW2VBto1Do3rQbSnIwdIomwGs3dnOnFevt77HPH9biRd_CHzaCBLNK3vdtdZ15YYn9NU_6O285lR-V6jOOemUtIXSG4Xlqpxp9Mdcds93Xkl_MtBvBvpioL830OsiMpuIC1yOnR9a_0f1C2Z2oMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2887707105</pqid></control><display><type>article</type><title>Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3</title><source>SpringerLink Journals</source><creator>Wagdy, Reham ; Fathy, Alaa ; Elnekidy, Abdelaziz ; Salaheldin, Geylan ; Nazir, Hanan ; Fahmy, Rana ; Elkafrawy, Hagar ; Elkafrawy, Fatma</creator><creatorcontrib>Wagdy, Reham ; Fathy, Alaa ; Elnekidy, Abdelaziz ; Salaheldin, Geylan ; Nazir, Hanan ; Fahmy, Rana ; Elkafrawy, Hagar ; Elkafrawy, Fatma</creatorcontrib><description>Background
Myocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle cell disease.
Objective
In this study, cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease were evaluated using cardiac magnetic resonance imaging (MRI), tissue Doppler echocardiography and serum galectin-3.
Materials and methods
The study included 34 children with sickle cell disease who were compared with a similar number of healthy controls. Cardiac MRI was used to evaluate late gadolinium enhancement, native T1 mapping, extracellular volume, and T2* for estimation of iron load. Cardiac function and myocardial performance index (MPI, evaluated by tissue Doppler echocardiography) and serum galectin-3 were compared to controls.
Results
The mean age of the included patients was 13.3 ± 3.2 years. Myocardial iron load by T2* was normal. The mean level of extracellular volume (35.41 ± 5.02%) was significantly associated with the frequency of vaso-occlusive crises (
P
= 0.017) and negatively correlated with hemoglobin levels (
P
= 0.005). Galectin-3 levels were significantly higher among cases than controls (
P
=
0.00)
, at a cutoff value on the receiver operating characteristic curve of 6.5 ng/ml, sensitivity of 82.5% and specificity of 72.8%. The extracellular volume was significantly higher in cases, with a MPI > 0.4.
Conclusion
Diffuse interstitial myocardial fibrosis can be detected early in children with sickle cell disease using T1 mapping and is associated with a high frequency of vaso-occlusive crisis. MPI of the left ventricle and serum galectin-3 are recommended screening tools for subclinical cardiac abnormalities.
Graphical abstract</description><identifier>ISSN: 1432-1998</identifier><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-023-05750-2</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abnormalities ; Cardiomyopathy ; Children ; Coronary artery disease ; Doppler effect ; Echocardiography ; Fibrosis ; Gadolinium ; Galectin-3 ; Heart diseases ; Hemoglobin ; Imaging ; Iron ; Magnetic resonance imaging ; Mapping ; Medical imaging ; Medicine ; Medicine & Public Health ; Neuroradiology ; Nuclear Medicine ; Oncology ; Original Article ; Pathogenicity ; Pediatrics ; Performance evaluation ; Performance indices ; Radiology ; Sickle cell disease ; Ultrasound ; Ventricle</subject><ispartof>Pediatric radiology, 2023-11, Vol.53 (12), p.2515-2527</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c347t-27ec56d23cbefd235aedf589862c9c92515a0647c319a268980d5ef04da55b583</cites><orcidid>0000-0002-3607-9107 ; 0009-0009-0063-5405 ; 0000-0001-6258-9576 ; 0000-0003-0738-9306</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00247-023-05750-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00247-023-05750-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Wagdy, Reham</creatorcontrib><creatorcontrib>Fathy, Alaa</creatorcontrib><creatorcontrib>Elnekidy, Abdelaziz</creatorcontrib><creatorcontrib>Salaheldin, Geylan</creatorcontrib><creatorcontrib>Nazir, Hanan</creatorcontrib><creatorcontrib>Fahmy, Rana</creatorcontrib><creatorcontrib>Elkafrawy, Hagar</creatorcontrib><creatorcontrib>Elkafrawy, Fatma</creatorcontrib><title>Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><description>Background
Myocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle cell disease.
Objective
In this study, cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease were evaluated using cardiac magnetic resonance imaging (MRI), tissue Doppler echocardiography and serum galectin-3.
Materials and methods
The study included 34 children with sickle cell disease who were compared with a similar number of healthy controls. Cardiac MRI was used to evaluate late gadolinium enhancement, native T1 mapping, extracellular volume, and T2* for estimation of iron load. Cardiac function and myocardial performance index (MPI, evaluated by tissue Doppler echocardiography) and serum galectin-3 were compared to controls.
Results
The mean age of the included patients was 13.3 ± 3.2 years. Myocardial iron load by T2* was normal. The mean level of extracellular volume (35.41 ± 5.02%) was significantly associated with the frequency of vaso-occlusive crises (
P
= 0.017) and negatively correlated with hemoglobin levels (
P
= 0.005). Galectin-3 levels were significantly higher among cases than controls (
P
=
0.00)
, at a cutoff value on the receiver operating characteristic curve of 6.5 ng/ml, sensitivity of 82.5% and specificity of 72.8%. The extracellular volume was significantly higher in cases, with a MPI > 0.4.
Conclusion
Diffuse interstitial myocardial fibrosis can be detected early in children with sickle cell disease using T1 mapping and is associated with a high frequency of vaso-occlusive crisis. MPI of the left ventricle and serum galectin-3 are recommended screening tools for subclinical cardiac abnormalities.
Graphical abstract</description><subject>Abnormalities</subject><subject>Cardiomyopathy</subject><subject>Children</subject><subject>Coronary artery disease</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Fibrosis</subject><subject>Gadolinium</subject><subject>Galectin-3</subject><subject>Heart diseases</subject><subject>Hemoglobin</subject><subject>Imaging</subject><subject>Iron</subject><subject>Magnetic resonance imaging</subject><subject>Mapping</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pathogenicity</subject><subject>Pediatrics</subject><subject>Performance evaluation</subject><subject>Performance indices</subject><subject>Radiology</subject><subject>Sickle cell disease</subject><subject>Ultrasound</subject><subject>Ventricle</subject><issn>1432-1998</issn><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctu1TAQhiMEEqXwAqwssWHRFF_iOFmiqlykSmxgbc2ZTHJcfJyDJwH1nXhIfBpEEQtWM_J8_4xn_qp6qeSlktK9YSl142qpTS2ts7LWj6oz1Rhdq77vHv-VP62eMd9KKY1V5qz6ef0d4gpLmJOYR4GQhwAoxrDLMwcWkAbB6w5jSAEh_gFwD2kiFiGVNMQhUxI_wrIXHPBrJIEUoxgCEzCJlUOaxAGmREtAkYnnBAlJhPJWSheCcD_ft56nDMf93cU2mPJ6EBNEwiWk2jyvnowQmV78jufVl3fXn68-1Def3n-8entTo2ncUmtHaNtBG9zRWIIFGkbb9V2rscdeW2VBto1Do3rQbSnIwdIomwGs3dnOnFevt77HPH9biRd_CHzaCBLNK3vdtdZ15YYn9NU_6O285lR-V6jOOemUtIXSG4Xlqpxp9Mdcds93Xkl_MtBvBvpioL830OsiMpuIC1yOnR9a_0f1C2Z2oMQ</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Wagdy, Reham</creator><creator>Fathy, Alaa</creator><creator>Elnekidy, Abdelaziz</creator><creator>Salaheldin, Geylan</creator><creator>Nazir, Hanan</creator><creator>Fahmy, Rana</creator><creator>Elkafrawy, Hagar</creator><creator>Elkafrawy, Fatma</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3607-9107</orcidid><orcidid>https://orcid.org/0009-0009-0063-5405</orcidid><orcidid>https://orcid.org/0000-0001-6258-9576</orcidid><orcidid>https://orcid.org/0000-0003-0738-9306</orcidid></search><sort><creationdate>20231101</creationdate><title>Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3</title><author>Wagdy, Reham ; Fathy, Alaa ; Elnekidy, Abdelaziz ; Salaheldin, Geylan ; Nazir, Hanan ; Fahmy, Rana ; Elkafrawy, Hagar ; Elkafrawy, Fatma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-27ec56d23cbefd235aedf589862c9c92515a0647c319a268980d5ef04da55b583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abnormalities</topic><topic>Cardiomyopathy</topic><topic>Children</topic><topic>Coronary artery disease</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Fibrosis</topic><topic>Gadolinium</topic><topic>Galectin-3</topic><topic>Heart diseases</topic><topic>Hemoglobin</topic><topic>Imaging</topic><topic>Iron</topic><topic>Magnetic resonance imaging</topic><topic>Mapping</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pathogenicity</topic><topic>Pediatrics</topic><topic>Performance evaluation</topic><topic>Performance indices</topic><topic>Radiology</topic><topic>Sickle cell disease</topic><topic>Ultrasound</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagdy, Reham</creatorcontrib><creatorcontrib>Fathy, Alaa</creatorcontrib><creatorcontrib>Elnekidy, Abdelaziz</creatorcontrib><creatorcontrib>Salaheldin, Geylan</creatorcontrib><creatorcontrib>Nazir, Hanan</creatorcontrib><creatorcontrib>Fahmy, Rana</creatorcontrib><creatorcontrib>Elkafrawy, Hagar</creatorcontrib><creatorcontrib>Elkafrawy, Fatma</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagdy, Reham</au><au>Fathy, Alaa</au><au>Elnekidy, Abdelaziz</au><au>Salaheldin, Geylan</au><au>Nazir, Hanan</au><au>Fahmy, Rana</au><au>Elkafrawy, Hagar</au><au>Elkafrawy, Fatma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3</atitle><jtitle>Pediatric radiology</jtitle><stitle>Pediatr Radiol</stitle><date>2023-11-01</date><risdate>2023</risdate><volume>53</volume><issue>12</issue><spage>2515</spage><epage>2527</epage><pages>2515-2527</pages><issn>1432-1998</issn><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Background
Myocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle cell disease.
Objective
In this study, cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease were evaluated using cardiac magnetic resonance imaging (MRI), tissue Doppler echocardiography and serum galectin-3.
Materials and methods
The study included 34 children with sickle cell disease who were compared with a similar number of healthy controls. Cardiac MRI was used to evaluate late gadolinium enhancement, native T1 mapping, extracellular volume, and T2* for estimation of iron load. Cardiac function and myocardial performance index (MPI, evaluated by tissue Doppler echocardiography) and serum galectin-3 were compared to controls.
Results
The mean age of the included patients was 13.3 ± 3.2 years. Myocardial iron load by T2* was normal. The mean level of extracellular volume (35.41 ± 5.02%) was significantly associated with the frequency of vaso-occlusive crises (
P
= 0.017) and negatively correlated with hemoglobin levels (
P
= 0.005). Galectin-3 levels were significantly higher among cases than controls (
P
=
0.00)
, at a cutoff value on the receiver operating characteristic curve of 6.5 ng/ml, sensitivity of 82.5% and specificity of 72.8%. The extracellular volume was significantly higher in cases, with a MPI > 0.4.
Conclusion
Diffuse interstitial myocardial fibrosis can be detected early in children with sickle cell disease using T1 mapping and is associated with a high frequency of vaso-occlusive crisis. MPI of the left ventricle and serum galectin-3 are recommended screening tools for subclinical cardiac abnormalities.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00247-023-05750-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3607-9107</orcidid><orcidid>https://orcid.org/0009-0009-0063-5405</orcidid><orcidid>https://orcid.org/0000-0001-6258-9576</orcidid><orcidid>https://orcid.org/0000-0003-0738-9306</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-1998 |
| ispartof | Pediatric radiology, 2023-11, Vol.53 (12), p.2515-2527 |
| issn | 1432-1998 0301-0449 1432-1998 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2865780008 |
| source | SpringerLink Journals |
| subjects | Abnormalities Cardiomyopathy Children Coronary artery disease Doppler effect Echocardiography Fibrosis Gadolinium Galectin-3 Heart diseases Hemoglobin Imaging Iron Magnetic resonance imaging Mapping Medical imaging Medicine Medicine & Public Health Neuroradiology Nuclear Medicine Oncology Original Article Pathogenicity Pediatrics Performance evaluation Performance indices Radiology Sickle cell disease Ultrasound Ventricle |
| title | Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T09%3A09%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20cardiac%20fibrosis%20and%20subclinical%20cardiac%20changes%20in%20children%20with%20sickle%20cell%20disease%20using%20magnetic%20resonance%20imaging,%20echocardiography,%20and%20serum%20galectin-3&rft.jtitle=Pediatric%20radiology&rft.au=Wagdy,%20Reham&rft.date=2023-11-01&rft.volume=53&rft.issue=12&rft.spage=2515&rft.epage=2527&rft.pages=2515-2527&rft.issn=1432-1998&rft.eissn=1432-1998&rft_id=info:doi/10.1007/s00247-023-05750-2&rft_dat=%3Cproquest_cross%3E2887707105%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2887707105&rft_id=info:pmid/&rfr_iscdi=true |