Diabetes mellitus and obesity among South Asians with ischemic stroke across three countries
Background: Diabetes mellitus and central obesity are more common among South Asian populations than among White British people. This study explores the differences in diabetes and obesity in South Asians with stroke living in the United Kingdom, India, and Qatar compared with White British stroke p...
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| Veröffentlicht in: | International journal of stroke 2024-02, Vol.19 (2), p.235-243 |
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| creator | Ken-Dror, Gie Ajami, Intisar Han, Thang S Aurelius, Taylor Maheshwari, Ankita Hail, Hassan Al Deleu, Dirk Sharma, Sapna D Amlani, Sageet Gunathilagan, Gunaratnam Cohen, David L Rajkumar, Chakravarthi Maguire, Stuart Ispoglou, Sissi Balogun, Ibrahim Parry, Anthea Sekaran, Lakshmanan Syed, Hafiz Lawrence, Enas Singh, Ravneeta Hassan, Ahamad Wharton, Chris Javaid, Khalid Goorah, Neetish Carr, Peter Abdus Sami, Eman Ali, Musab Hussein, Hassan Al Osman Abuzaid, Hassan Sharif, Khalid Ram Sharma, Shri Sylaja, PN Yousef Khan, Fahmi Prasad, Kameshwar Sharma, Pankaj |
| description | Background:
Diabetes mellitus and central obesity are more common among South Asian populations than among White British people. This study explores the differences in diabetes and obesity in South Asians with stroke living in the United Kingdom, India, and Qatar compared with White British stroke patients.
Methods:
The study included the UK, Indian, and Qatari arms of the ongoing large Bio-Repository of DNA in Stroke (BRAINS) international prospective hospital-based study for South Asian stroke. BRAINS includes 4580 South Asian and White British recruits from UK, Indian, and Qatar sites with first-ever ischemic stroke.
Results:
The study population comprises 1751 White British (WB) UK residents, 1165 British South Asians (BSA), 1096 South Asians in India (ISA), and 568 South Asians in Qatar (QSA). ISA, BSA, and QSA South Asians suffered from higher prevalence of diabetes compared with WB by 14.5% (ISA: 95% confidence interval (CI) = 18.6–33.0, p |
| doi_str_mv | 10.1177/17474930231203149 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2864896863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_17474930231203149</sage_id><sourcerecordid>2864896863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c335t-5afddbb3fc51c63ecbadfbc3705a566c7dec951cddd4f0076bb70890d7b252a53</originalsourceid><addsrcrecordid>eNp9UE1PAjEUbIxGEP0BXkyPXsB2u9vSI8HPhMSDejPZ9OMtFNkttt0Y_r2LIBcTT2_y3rzJzCB0ScmIUiFuqMhFLhnJGM0Io7k8Qv3tbpjLXB4fMCM9dBbjkpC8EIyfoh4TgvBMyj56v3VKQ4KIa1itXGojVo3FXkN0aYNV7Zs5fvFtWuBJdKqJ-Mt12EWzgNoZHFPwH4CVCT5GnBYBABvfNik4iOfopFKrCBf7OUBv93ev08fh7PnhaTqZDQ1jRRoWqrJWa1aZghrOwGhlK22YIIUqODfCgpHdyVqbV4QIrrUgY0ms0FmRqYIN0PVOdx38ZwsxlXVnsMujGvBtLLMxz8eSjznrqHRH_TEcoCrXwdUqbEpKym2p5Z9Su5-rvXyra7CHj98WO8JoR4hqDuXSt6Hp4v6j-A1U3oEb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2864896863</pqid></control><display><type>article</type><title>Diabetes mellitus and obesity among South Asians with ischemic stroke across three countries</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Ken-Dror, Gie ; Ajami, Intisar ; Han, Thang S ; Aurelius, Taylor ; Maheshwari, Ankita ; Hail, Hassan Al ; Deleu, Dirk ; Sharma, Sapna D ; Amlani, Sageet ; Gunathilagan, Gunaratnam ; Cohen, David L ; Rajkumar, Chakravarthi ; Maguire, Stuart ; Ispoglou, Sissi ; Balogun, Ibrahim ; Parry, Anthea ; Sekaran, Lakshmanan ; Syed, Hafiz ; Lawrence, Enas ; Singh, Ravneeta ; Hassan, Ahamad ; Wharton, Chris ; Javaid, Khalid ; Goorah, Neetish ; Carr, Peter ; Abdus Sami, Eman ; Ali, Musab ; Hussein, Hassan Al ; Osman Abuzaid, Hassan ; Sharif, Khalid ; Ram Sharma, Shri ; Sylaja, PN ; Yousef Khan, Fahmi ; Prasad, Kameshwar ; Sharma, Pankaj</creator><creatorcontrib>Ken-Dror, Gie ; Ajami, Intisar ; Han, Thang S ; Aurelius, Taylor ; Maheshwari, Ankita ; Hail, Hassan Al ; Deleu, Dirk ; Sharma, Sapna D ; Amlani, Sageet ; Gunathilagan, Gunaratnam ; Cohen, David L ; Rajkumar, Chakravarthi ; Maguire, Stuart ; Ispoglou, Sissi ; Balogun, Ibrahim ; Parry, Anthea ; Sekaran, Lakshmanan ; Syed, Hafiz ; Lawrence, Enas ; Singh, Ravneeta ; Hassan, Ahamad ; Wharton, Chris ; Javaid, Khalid ; Goorah, Neetish ; Carr, Peter ; Abdus Sami, Eman ; Ali, Musab ; Hussein, Hassan Al ; Osman Abuzaid, Hassan ; Sharif, Khalid ; Ram Sharma, Shri ; Sylaja, PN ; Yousef Khan, Fahmi ; Prasad, Kameshwar ; Sharma, Pankaj</creatorcontrib><description><![CDATA[Background:
Diabetes mellitus and central obesity are more common among South Asian populations than among White British people. This study explores the differences in diabetes and obesity in South Asians with stroke living in the United Kingdom, India, and Qatar compared with White British stroke patients.
Methods:
The study included the UK, Indian, and Qatari arms of the ongoing large Bio-Repository of DNA in Stroke (BRAINS) international prospective hospital-based study for South Asian stroke. BRAINS includes 4580 South Asian and White British recruits from UK, Indian, and Qatar sites with first-ever ischemic stroke.
Results:
The study population comprises 1751 White British (WB) UK residents, 1165 British South Asians (BSA), 1096 South Asians in India (ISA), and 568 South Asians in Qatar (QSA). ISA, BSA, and QSA South Asians suffered from higher prevalence of diabetes compared with WB by 14.5% (ISA: 95% confidence interval (CI) = 18.6–33.0, p < 0.001), 31.7% (BSA: 95% CI = 35.1–50.2, p < 0.001), and 32.7% (QSA: 95% CI = 28.1–37.3, p < 0.001), respectively. Although WB had the highest prevalence of body mass index (BMI) above 27 kg/m2 compared with South Asian patients (37% vs 21%, p < 0.001), South Asian patients had a higher waist circumference than WB (94.8 cm vs 90.8 cm, p < 0.001). Adjusting for traditional stroke risk factors, ISA, BSA, and QSA continued to display an increased risk of diabetes compared with WB by 3.28 (95% CI: 2.53–4.25, p < 0.001), 3.61 (95% CI: 2.90–4.51, p < 0.001), and 5.24 (95% CI: 3.93–7.00, p < 0.001), respectively.
Conclusion:
South Asian ischemic stroke patients living in Britain and Qatar have a near 3.5-fold risk of diabetes compared with White British stroke patients. Their body composition may partly help explain that increased risk. These findings have important implications for public health policymakers in nations with large South Asian populations.]]></description><identifier>ISSN: 1747-4930</identifier><identifier>ISSN: 1747-4949</identifier><identifier>EISSN: 1747-4949</identifier><identifier>DOI: 10.1177/17474930231203149</identifier><identifier>PMID: 37706299</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Diabetes Mellitus - epidemiology ; European People ; Humans ; Ischemic Stroke - epidemiology ; Obesity - epidemiology ; Prospective Studies ; Risk Factors ; South Asian People ; United Kingdom - epidemiology</subject><ispartof>International journal of stroke, 2024-02, Vol.19 (2), p.235-243</ispartof><rights>2023 World Stroke Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-5afddbb3fc51c63ecbadfbc3705a566c7dec951cddd4f0076bb70890d7b252a53</cites><orcidid>0000-0003-2570-0938 ; 0000-0003-3747-7112 ; 0000-0001-5925-1910</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/17474930231203149$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/17474930231203149$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37706299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ken-Dror, Gie</creatorcontrib><creatorcontrib>Ajami, Intisar</creatorcontrib><creatorcontrib>Han, Thang S</creatorcontrib><creatorcontrib>Aurelius, Taylor</creatorcontrib><creatorcontrib>Maheshwari, Ankita</creatorcontrib><creatorcontrib>Hail, Hassan Al</creatorcontrib><creatorcontrib>Deleu, Dirk</creatorcontrib><creatorcontrib>Sharma, Sapna D</creatorcontrib><creatorcontrib>Amlani, Sageet</creatorcontrib><creatorcontrib>Gunathilagan, Gunaratnam</creatorcontrib><creatorcontrib>Cohen, David L</creatorcontrib><creatorcontrib>Rajkumar, Chakravarthi</creatorcontrib><creatorcontrib>Maguire, Stuart</creatorcontrib><creatorcontrib>Ispoglou, Sissi</creatorcontrib><creatorcontrib>Balogun, Ibrahim</creatorcontrib><creatorcontrib>Parry, Anthea</creatorcontrib><creatorcontrib>Sekaran, Lakshmanan</creatorcontrib><creatorcontrib>Syed, Hafiz</creatorcontrib><creatorcontrib>Lawrence, Enas</creatorcontrib><creatorcontrib>Singh, Ravneeta</creatorcontrib><creatorcontrib>Hassan, Ahamad</creatorcontrib><creatorcontrib>Wharton, Chris</creatorcontrib><creatorcontrib>Javaid, Khalid</creatorcontrib><creatorcontrib>Goorah, Neetish</creatorcontrib><creatorcontrib>Carr, Peter</creatorcontrib><creatorcontrib>Abdus Sami, Eman</creatorcontrib><creatorcontrib>Ali, Musab</creatorcontrib><creatorcontrib>Hussein, Hassan Al</creatorcontrib><creatorcontrib>Osman Abuzaid, Hassan</creatorcontrib><creatorcontrib>Sharif, Khalid</creatorcontrib><creatorcontrib>Ram Sharma, Shri</creatorcontrib><creatorcontrib>Sylaja, PN</creatorcontrib><creatorcontrib>Yousef Khan, Fahmi</creatorcontrib><creatorcontrib>Prasad, Kameshwar</creatorcontrib><creatorcontrib>Sharma, Pankaj</creatorcontrib><title>Diabetes mellitus and obesity among South Asians with ischemic stroke across three countries</title><title>International journal of stroke</title><addtitle>Int J Stroke</addtitle><description><![CDATA[Background:
Diabetes mellitus and central obesity are more common among South Asian populations than among White British people. This study explores the differences in diabetes and obesity in South Asians with stroke living in the United Kingdom, India, and Qatar compared with White British stroke patients.
Methods:
The study included the UK, Indian, and Qatari arms of the ongoing large Bio-Repository of DNA in Stroke (BRAINS) international prospective hospital-based study for South Asian stroke. BRAINS includes 4580 South Asian and White British recruits from UK, Indian, and Qatar sites with first-ever ischemic stroke.
Results:
The study population comprises 1751 White British (WB) UK residents, 1165 British South Asians (BSA), 1096 South Asians in India (ISA), and 568 South Asians in Qatar (QSA). ISA, BSA, and QSA South Asians suffered from higher prevalence of diabetes compared with WB by 14.5% (ISA: 95% confidence interval (CI) = 18.6–33.0, p < 0.001), 31.7% (BSA: 95% CI = 35.1–50.2, p < 0.001), and 32.7% (QSA: 95% CI = 28.1–37.3, p < 0.001), respectively. Although WB had the highest prevalence of body mass index (BMI) above 27 kg/m2 compared with South Asian patients (37% vs 21%, p < 0.001), South Asian patients had a higher waist circumference than WB (94.8 cm vs 90.8 cm, p < 0.001). Adjusting for traditional stroke risk factors, ISA, BSA, and QSA continued to display an increased risk of diabetes compared with WB by 3.28 (95% CI: 2.53–4.25, p < 0.001), 3.61 (95% CI: 2.90–4.51, p < 0.001), and 5.24 (95% CI: 3.93–7.00, p < 0.001), respectively.
Conclusion:
South Asian ischemic stroke patients living in Britain and Qatar have a near 3.5-fold risk of diabetes compared with White British stroke patients. Their body composition may partly help explain that increased risk. These findings have important implications for public health policymakers in nations with large South Asian populations.]]></description><subject>Diabetes Mellitus - epidemiology</subject><subject>European People</subject><subject>Humans</subject><subject>Ischemic Stroke - epidemiology</subject><subject>Obesity - epidemiology</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>South Asian People</subject><subject>United Kingdom - epidemiology</subject><issn>1747-4930</issn><issn>1747-4949</issn><issn>1747-4949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9UE1PAjEUbIxGEP0BXkyPXsB2u9vSI8HPhMSDejPZ9OMtFNkttt0Y_r2LIBcTT2_y3rzJzCB0ScmIUiFuqMhFLhnJGM0Io7k8Qv3tbpjLXB4fMCM9dBbjkpC8EIyfoh4TgvBMyj56v3VKQ4KIa1itXGojVo3FXkN0aYNV7Zs5fvFtWuBJdKqJ-Mt12EWzgNoZHFPwH4CVCT5GnBYBABvfNik4iOfopFKrCBf7OUBv93ev08fh7PnhaTqZDQ1jRRoWqrJWa1aZghrOwGhlK22YIIUqODfCgpHdyVqbV4QIrrUgY0ms0FmRqYIN0PVOdx38ZwsxlXVnsMujGvBtLLMxz8eSjznrqHRH_TEcoCrXwdUqbEpKym2p5Z9Su5-rvXyra7CHj98WO8JoR4hqDuXSt6Hp4v6j-A1U3oEb</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Ken-Dror, Gie</creator><creator>Ajami, Intisar</creator><creator>Han, Thang S</creator><creator>Aurelius, Taylor</creator><creator>Maheshwari, Ankita</creator><creator>Hail, Hassan Al</creator><creator>Deleu, Dirk</creator><creator>Sharma, Sapna D</creator><creator>Amlani, Sageet</creator><creator>Gunathilagan, Gunaratnam</creator><creator>Cohen, David L</creator><creator>Rajkumar, Chakravarthi</creator><creator>Maguire, Stuart</creator><creator>Ispoglou, Sissi</creator><creator>Balogun, Ibrahim</creator><creator>Parry, Anthea</creator><creator>Sekaran, Lakshmanan</creator><creator>Syed, Hafiz</creator><creator>Lawrence, Enas</creator><creator>Singh, Ravneeta</creator><creator>Hassan, Ahamad</creator><creator>Wharton, Chris</creator><creator>Javaid, Khalid</creator><creator>Goorah, Neetish</creator><creator>Carr, Peter</creator><creator>Abdus Sami, Eman</creator><creator>Ali, Musab</creator><creator>Hussein, Hassan Al</creator><creator>Osman Abuzaid, Hassan</creator><creator>Sharif, Khalid</creator><creator>Ram Sharma, Shri</creator><creator>Sylaja, PN</creator><creator>Yousef Khan, Fahmi</creator><creator>Prasad, Kameshwar</creator><creator>Sharma, Pankaj</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2570-0938</orcidid><orcidid>https://orcid.org/0000-0003-3747-7112</orcidid><orcidid>https://orcid.org/0000-0001-5925-1910</orcidid></search><sort><creationdate>202402</creationdate><title>Diabetes mellitus and obesity among South Asians with ischemic stroke across three countries</title><author>Ken-Dror, Gie ; Ajami, Intisar ; Han, Thang S ; Aurelius, Taylor ; Maheshwari, Ankita ; Hail, Hassan Al ; Deleu, Dirk ; Sharma, Sapna D ; Amlani, Sageet ; Gunathilagan, Gunaratnam ; Cohen, David L ; Rajkumar, Chakravarthi ; Maguire, Stuart ; Ispoglou, Sissi ; Balogun, Ibrahim ; Parry, Anthea ; Sekaran, Lakshmanan ; Syed, Hafiz ; Lawrence, Enas ; Singh, Ravneeta ; Hassan, Ahamad ; Wharton, Chris ; Javaid, Khalid ; Goorah, Neetish ; Carr, Peter ; Abdus Sami, Eman ; Ali, Musab ; Hussein, Hassan Al ; Osman Abuzaid, Hassan ; Sharif, Khalid ; Ram Sharma, Shri ; Sylaja, PN ; Yousef Khan, Fahmi ; Prasad, Kameshwar ; Sharma, Pankaj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-5afddbb3fc51c63ecbadfbc3705a566c7dec951cddd4f0076bb70890d7b252a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Diabetes Mellitus - epidemiology</topic><topic>European People</topic><topic>Humans</topic><topic>Ischemic Stroke - epidemiology</topic><topic>Obesity - epidemiology</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>South Asian People</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ken-Dror, Gie</creatorcontrib><creatorcontrib>Ajami, Intisar</creatorcontrib><creatorcontrib>Han, Thang S</creatorcontrib><creatorcontrib>Aurelius, Taylor</creatorcontrib><creatorcontrib>Maheshwari, Ankita</creatorcontrib><creatorcontrib>Hail, Hassan Al</creatorcontrib><creatorcontrib>Deleu, Dirk</creatorcontrib><creatorcontrib>Sharma, Sapna D</creatorcontrib><creatorcontrib>Amlani, Sageet</creatorcontrib><creatorcontrib>Gunathilagan, Gunaratnam</creatorcontrib><creatorcontrib>Cohen, David L</creatorcontrib><creatorcontrib>Rajkumar, Chakravarthi</creatorcontrib><creatorcontrib>Maguire, Stuart</creatorcontrib><creatorcontrib>Ispoglou, Sissi</creatorcontrib><creatorcontrib>Balogun, Ibrahim</creatorcontrib><creatorcontrib>Parry, Anthea</creatorcontrib><creatorcontrib>Sekaran, Lakshmanan</creatorcontrib><creatorcontrib>Syed, Hafiz</creatorcontrib><creatorcontrib>Lawrence, Enas</creatorcontrib><creatorcontrib>Singh, Ravneeta</creatorcontrib><creatorcontrib>Hassan, Ahamad</creatorcontrib><creatorcontrib>Wharton, Chris</creatorcontrib><creatorcontrib>Javaid, Khalid</creatorcontrib><creatorcontrib>Goorah, Neetish</creatorcontrib><creatorcontrib>Carr, Peter</creatorcontrib><creatorcontrib>Abdus Sami, Eman</creatorcontrib><creatorcontrib>Ali, Musab</creatorcontrib><creatorcontrib>Hussein, Hassan Al</creatorcontrib><creatorcontrib>Osman Abuzaid, Hassan</creatorcontrib><creatorcontrib>Sharif, Khalid</creatorcontrib><creatorcontrib>Ram Sharma, Shri</creatorcontrib><creatorcontrib>Sylaja, PN</creatorcontrib><creatorcontrib>Yousef Khan, Fahmi</creatorcontrib><creatorcontrib>Prasad, Kameshwar</creatorcontrib><creatorcontrib>Sharma, Pankaj</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of stroke</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ken-Dror, Gie</au><au>Ajami, Intisar</au><au>Han, Thang S</au><au>Aurelius, Taylor</au><au>Maheshwari, Ankita</au><au>Hail, Hassan Al</au><au>Deleu, Dirk</au><au>Sharma, Sapna D</au><au>Amlani, Sageet</au><au>Gunathilagan, Gunaratnam</au><au>Cohen, David L</au><au>Rajkumar, Chakravarthi</au><au>Maguire, Stuart</au><au>Ispoglou, Sissi</au><au>Balogun, Ibrahim</au><au>Parry, Anthea</au><au>Sekaran, Lakshmanan</au><au>Syed, Hafiz</au><au>Lawrence, Enas</au><au>Singh, Ravneeta</au><au>Hassan, Ahamad</au><au>Wharton, Chris</au><au>Javaid, Khalid</au><au>Goorah, Neetish</au><au>Carr, Peter</au><au>Abdus Sami, Eman</au><au>Ali, Musab</au><au>Hussein, Hassan Al</au><au>Osman Abuzaid, Hassan</au><au>Sharif, Khalid</au><au>Ram Sharma, Shri</au><au>Sylaja, PN</au><au>Yousef Khan, Fahmi</au><au>Prasad, Kameshwar</au><au>Sharma, Pankaj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes mellitus and obesity among South Asians with ischemic stroke across three countries</atitle><jtitle>International journal of stroke</jtitle><addtitle>Int J Stroke</addtitle><date>2024-02</date><risdate>2024</risdate><volume>19</volume><issue>2</issue><spage>235</spage><epage>243</epage><pages>235-243</pages><issn>1747-4930</issn><issn>1747-4949</issn><eissn>1747-4949</eissn><abstract><![CDATA[Background:
Diabetes mellitus and central obesity are more common among South Asian populations than among White British people. This study explores the differences in diabetes and obesity in South Asians with stroke living in the United Kingdom, India, and Qatar compared with White British stroke patients.
Methods:
The study included the UK, Indian, and Qatari arms of the ongoing large Bio-Repository of DNA in Stroke (BRAINS) international prospective hospital-based study for South Asian stroke. BRAINS includes 4580 South Asian and White British recruits from UK, Indian, and Qatar sites with first-ever ischemic stroke.
Results:
The study population comprises 1751 White British (WB) UK residents, 1165 British South Asians (BSA), 1096 South Asians in India (ISA), and 568 South Asians in Qatar (QSA). ISA, BSA, and QSA South Asians suffered from higher prevalence of diabetes compared with WB by 14.5% (ISA: 95% confidence interval (CI) = 18.6–33.0, p < 0.001), 31.7% (BSA: 95% CI = 35.1–50.2, p < 0.001), and 32.7% (QSA: 95% CI = 28.1–37.3, p < 0.001), respectively. Although WB had the highest prevalence of body mass index (BMI) above 27 kg/m2 compared with South Asian patients (37% vs 21%, p < 0.001), South Asian patients had a higher waist circumference than WB (94.8 cm vs 90.8 cm, p < 0.001). Adjusting for traditional stroke risk factors, ISA, BSA, and QSA continued to display an increased risk of diabetes compared with WB by 3.28 (95% CI: 2.53–4.25, p < 0.001), 3.61 (95% CI: 2.90–4.51, p < 0.001), and 5.24 (95% CI: 3.93–7.00, p < 0.001), respectively.
Conclusion:
South Asian ischemic stroke patients living in Britain and Qatar have a near 3.5-fold risk of diabetes compared with White British stroke patients. Their body composition may partly help explain that increased risk. These findings have important implications for public health policymakers in nations with large South Asian populations.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37706299</pmid><doi>10.1177/17474930231203149</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2570-0938</orcidid><orcidid>https://orcid.org/0000-0003-3747-7112</orcidid><orcidid>https://orcid.org/0000-0001-5925-1910</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of stroke, 2024-02, Vol.19 (2), p.235-243 |
| issn | 1747-4930 1747-4949 1747-4949 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Diabetes Mellitus - epidemiology European People Humans Ischemic Stroke - epidemiology Obesity - epidemiology Prospective Studies Risk Factors South Asian People United Kingdom - epidemiology |
| title | Diabetes mellitus and obesity among South Asians with ischemic stroke across three countries |
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