From lipid nanoparticles to precision therapies for hematologic diseases: getting closer

From lipid nanoparticles to precision therapies for hematologic diseases: getting closer

Modification of hematopoietic stem cells, in both molecular and cellular terms, has been a long-pursued goal in experimental and clinical hematology. In a recent article published in Science, Breda et al describe a novel method for the genetic modification of hematopoietic stem cells. This new exper...

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Veröffentlicht in:Journal of leukocyte biology 2023-11, Vol.114 (6), p.515-517
1. Verfasser: Mayani, Hector
Format: Artikel
Sprache:eng
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Hematologic Diseases - therapy
Hematologic Neoplasms - therapy
Hematopoietic Stem Cell Transplantation
Humans
Liposomes
Nanoparticles - therapeutic use
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container_title Journal of leukocyte biology
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description Modification of hematopoietic stem cells, in both molecular and cellular terms, has been a long-pursued goal in experimental and clinical hematology. In a recent article published in Science, Breda et al describe a novel method for the genetic modification of hematopoietic stem cells. This new experimental approach, based on the use of lipid nanoparticles, represents an important step forward in the development of genetic and cellular therapies for hematologic diseases. A general overview of the article by Breda et al and some analysis, comments, and perspectives are presented in this editorial commentary.
doi_str_mv 10.1093/jleuko/qiad108
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subjects Hematologic Diseases - therapy
Hematologic Neoplasms - therapy
Hematopoietic Stem Cell Transplantation
Humans
Liposomes
Nanoparticles - therapeutic use
title From lipid nanoparticles to precision therapies for hematologic diseases: getting closer
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