Removal of gemcitabine-induced senescent cancer cells by targeting glutaminase1 improves the therapeutic effect in pancreatic ductal adenocarcinoma

Insufficient cancer treatment can induce senescent cancer cell formation and treatment resistance. The characteristics of induced senescent cancer (iSnCa) cells remain unclear. Pancreatic ductal adenocarcinoma (PDAC) has a low and nondurable response rate to current treatments. Our study aimed to an...

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Veröffentlicht in:	International journal of cancer 2024-03, Vol.154 (5), p.912-925
Hauptverfasser:	Oyama, Keisuke, Iwagami, Yoshifumi, Kobayashi, Shogo, Sasaki, Kazuki, Yamada, Daisaku, Tomimaru, Yoshito, Noda, Takehiro, Asaoka, Tadafumi, Takahashi, Hidenori, Tanemura, Masahiro, Doki, Yuichiro, Eguchi, Hidetoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animal models Apoptosis Cancer Cancer therapies Cell death Chemotherapy Clinical outcomes Gemcitabine Glutaminase Medical research Pancreas Pancreatic cancer Phenotypes Prognosis Senescence Treatment resistance
Online-Zugang:	Volltext
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