Late effects of medulloblastoma treatment: multidisciplinary approach of survivors
Purpose Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study’s aim is to review long-term follow-up outcomes of our cases with medulloblastoma....
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| Veröffentlicht in: | Child's nervous system 2024-02, Vol.40 (2), p.417-425 |
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| creator | Aktekin, Elif Habibe Kütük, Meryem Özlem Sangün, Özlem Yazıcı, Nalan Çaylaklı, Fatma Erol, İlknur Sarıalioğlu, Faik |
| description | Purpose
Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study’s aim is to review long-term follow-up outcomes of our cases with medulloblastoma.
Methods
Age at diagnosis, histological type of medulloblastoma, resection extension, chemotherapy and radiotherapy schemes, follow-up duration, and endocrinological, neuropsychiatric, cardiological, auditory, and visual examination results were evaluated in 20 patients diagnosed between 2007 and 2018 and followed 5 years and more.
Results
Twenty of 53 patients were included to the study. Eleven (55%) were male. Mean age at diagnosis was 6.95 years; mean age at the time of the study was 14 years. Mean follow-up time was 8.95 years. In terms of surgery, 14 (70%) were gross total, 1 (5%) was near total, and 2 (10%) were subtotal resection. In histopathological examination, 14 (70%) were classical medulloblastoma, 4 (20%) were desmoplastic medulloblastoma, and 1 (5%) was anaplastic medulloblastoma. With regard to endocrinological evaluation, 15 (75%) patients had hypothyroidism, 5 (25%) had growth hormone deficiency, 7 (35%) had clinical growth hormone deficiency, and 5 (25%) had sex hormone disorders. In neuropsychiatric examination, 11 (55%) patients had neurological sequelae, 18 (90%) patients had psychiatric issues, and 14 (70%) patients had two or more neuropsychiatric problems simultaneously. One (5%) patient had mitral valve insufficiency. Twelve patients (60%) had hearing loss. According to visual examination, 6 (30%) patients had refraction problem, 4 (20%) had cataract, and 1 (5%) had dry eye.
Conclusion
Careful monitoring of long-term side effects is important for improving the quality of life of medulloblastoma patients. Besides endocrinological and other somatic sequelae of the disease and treatment, increased neuropsychiatric problems showed us that only cure is not the issue while treating childhood medulloblastoma. |
| doi_str_mv | 10.1007/s00381-023-06146-1 |
| format | Article |
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Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study’s aim is to review long-term follow-up outcomes of our cases with medulloblastoma.
Methods
Age at diagnosis, histological type of medulloblastoma, resection extension, chemotherapy and radiotherapy schemes, follow-up duration, and endocrinological, neuropsychiatric, cardiological, auditory, and visual examination results were evaluated in 20 patients diagnosed between 2007 and 2018 and followed 5 years and more.
Results
Twenty of 53 patients were included to the study. Eleven (55%) were male. Mean age at diagnosis was 6.95 years; mean age at the time of the study was 14 years. Mean follow-up time was 8.95 years. In terms of surgery, 14 (70%) were gross total, 1 (5%) was near total, and 2 (10%) were subtotal resection. In histopathological examination, 14 (70%) were classical medulloblastoma, 4 (20%) were desmoplastic medulloblastoma, and 1 (5%) was anaplastic medulloblastoma. With regard to endocrinological evaluation, 15 (75%) patients had hypothyroidism, 5 (25%) had growth hormone deficiency, 7 (35%) had clinical growth hormone deficiency, and 5 (25%) had sex hormone disorders. In neuropsychiatric examination, 11 (55%) patients had neurological sequelae, 18 (90%) patients had psychiatric issues, and 14 (70%) patients had two or more neuropsychiatric problems simultaneously. One (5%) patient had mitral valve insufficiency. Twelve patients (60%) had hearing loss. According to visual examination, 6 (30%) patients had refraction problem, 4 (20%) had cataract, and 1 (5%) had dry eye.
Conclusion
Careful monitoring of long-term side effects is important for improving the quality of life of medulloblastoma patients. Besides endocrinological and other somatic sequelae of the disease and treatment, increased neuropsychiatric problems showed us that only cure is not the issue while treating childhood medulloblastoma.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-023-06146-1</identifier><identifier>PMID: 37698649</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Cerebellar Neoplasms - radiotherapy ; Child ; Disease Progression ; Female ; Growth Hormone ; Humans ; Male ; Medicine ; Medicine & Public Health ; Medulloblastoma - pathology ; Neurosciences ; Neurosurgery ; Original Article ; Quality of Life ; Survivors ; Young Adult</subject><ispartof>Child's nervous system, 2024-02, Vol.40 (2), p.417-425</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-a2ccd87ce14df214a70b6b2a4f35314414d5a193196e8e691274f7a619ef00053</cites><orcidid>0000-0002-0394-6219</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-023-06146-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-023-06146-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37698649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aktekin, Elif Habibe</creatorcontrib><creatorcontrib>Kütük, Meryem Özlem</creatorcontrib><creatorcontrib>Sangün, Özlem</creatorcontrib><creatorcontrib>Yazıcı, Nalan</creatorcontrib><creatorcontrib>Çaylaklı, Fatma</creatorcontrib><creatorcontrib>Erol, İlknur</creatorcontrib><creatorcontrib>Sarıalioğlu, Faik</creatorcontrib><title>Late effects of medulloblastoma treatment: multidisciplinary approach of survivors</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Purpose
Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study’s aim is to review long-term follow-up outcomes of our cases with medulloblastoma.
Methods
Age at diagnosis, histological type of medulloblastoma, resection extension, chemotherapy and radiotherapy schemes, follow-up duration, and endocrinological, neuropsychiatric, cardiological, auditory, and visual examination results were evaluated in 20 patients diagnosed between 2007 and 2018 and followed 5 years and more.
Results
Twenty of 53 patients were included to the study. Eleven (55%) were male. Mean age at diagnosis was 6.95 years; mean age at the time of the study was 14 years. Mean follow-up time was 8.95 years. In terms of surgery, 14 (70%) were gross total, 1 (5%) was near total, and 2 (10%) were subtotal resection. In histopathological examination, 14 (70%) were classical medulloblastoma, 4 (20%) were desmoplastic medulloblastoma, and 1 (5%) was anaplastic medulloblastoma. With regard to endocrinological evaluation, 15 (75%) patients had hypothyroidism, 5 (25%) had growth hormone deficiency, 7 (35%) had clinical growth hormone deficiency, and 5 (25%) had sex hormone disorders. In neuropsychiatric examination, 11 (55%) patients had neurological sequelae, 18 (90%) patients had psychiatric issues, and 14 (70%) patients had two or more neuropsychiatric problems simultaneously. One (5%) patient had mitral valve insufficiency. Twelve patients (60%) had hearing loss. According to visual examination, 6 (30%) patients had refraction problem, 4 (20%) had cataract, and 1 (5%) had dry eye.
Conclusion
Careful monitoring of long-term side effects is important for improving the quality of life of medulloblastoma patients. Besides endocrinological and other somatic sequelae of the disease and treatment, increased neuropsychiatric problems showed us that only cure is not the issue while treating childhood medulloblastoma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cerebellar Neoplasms - radiotherapy</subject><subject>Child</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Growth Hormone</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medulloblastoma - pathology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Quality of Life</subject><subject>Survivors</subject><subject>Young Adult</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMozjj6B1xIl26qN4-mjTsZfMGAILoOaZpoh7Qdk3TAf2_Gji5dXXJzzuGeD6FzDFcYoLwOALTCORCaA8eM5_gAzTGj6UkLOERzIAXPS2AwQychrAFwURFxjGa05KLiTMzRy0pFkxlrjY4hG2zWmWZ0bqidCnHoVBa9UbEzfbzJutHFtmmDbjeu7ZX_ytRm4welP3bGMPptux18OEVHVrlgzvZzgd7u716Xj_nq-eFpebvKNRFVzBXRuqlKbTBrLMFMlVDzmihmaUExY2ldKCwoFtxUhgtMSmZLxbEwFgAKukCXU2664XM0Icou3WacU70ZxiBJapgKU1olKZmk2g8heGPlxrddaiAxyB1LObGUiaX8YSlxMl3s88c6Ufmz_MJLAjoJQvrq342X62H0fer8X-w3O9l_0A</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Aktekin, Elif Habibe</creator><creator>Kütük, Meryem Özlem</creator><creator>Sangün, Özlem</creator><creator>Yazıcı, Nalan</creator><creator>Çaylaklı, Fatma</creator><creator>Erol, İlknur</creator><creator>Sarıalioğlu, Faik</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0394-6219</orcidid></search><sort><creationdate>20240201</creationdate><title>Late effects of medulloblastoma treatment: multidisciplinary approach of survivors</title><author>Aktekin, Elif Habibe ; Kütük, Meryem Özlem ; Sangün, Özlem ; Yazıcı, Nalan ; Çaylaklı, Fatma ; Erol, İlknur ; Sarıalioğlu, Faik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-a2ccd87ce14df214a70b6b2a4f35314414d5a193196e8e691274f7a619ef00053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cerebellar Neoplasms - radiotherapy</topic><topic>Child</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Growth Hormone</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medulloblastoma - pathology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Quality of Life</topic><topic>Survivors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aktekin, Elif Habibe</creatorcontrib><creatorcontrib>Kütük, Meryem Özlem</creatorcontrib><creatorcontrib>Sangün, Özlem</creatorcontrib><creatorcontrib>Yazıcı, Nalan</creatorcontrib><creatorcontrib>Çaylaklı, Fatma</creatorcontrib><creatorcontrib>Erol, İlknur</creatorcontrib><creatorcontrib>Sarıalioğlu, Faik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aktekin, Elif Habibe</au><au>Kütük, Meryem Özlem</au><au>Sangün, Özlem</au><au>Yazıcı, Nalan</au><au>Çaylaklı, Fatma</au><au>Erol, İlknur</au><au>Sarıalioğlu, Faik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Late effects of medulloblastoma treatment: multidisciplinary approach of survivors</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>40</volume><issue>2</issue><spage>417</spage><epage>425</epage><pages>417-425</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Purpose
Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study’s aim is to review long-term follow-up outcomes of our cases with medulloblastoma.
Methods
Age at diagnosis, histological type of medulloblastoma, resection extension, chemotherapy and radiotherapy schemes, follow-up duration, and endocrinological, neuropsychiatric, cardiological, auditory, and visual examination results were evaluated in 20 patients diagnosed between 2007 and 2018 and followed 5 years and more.
Results
Twenty of 53 patients were included to the study. Eleven (55%) were male. Mean age at diagnosis was 6.95 years; mean age at the time of the study was 14 years. Mean follow-up time was 8.95 years. In terms of surgery, 14 (70%) were gross total, 1 (5%) was near total, and 2 (10%) were subtotal resection. In histopathological examination, 14 (70%) were classical medulloblastoma, 4 (20%) were desmoplastic medulloblastoma, and 1 (5%) was anaplastic medulloblastoma. With regard to endocrinological evaluation, 15 (75%) patients had hypothyroidism, 5 (25%) had growth hormone deficiency, 7 (35%) had clinical growth hormone deficiency, and 5 (25%) had sex hormone disorders. In neuropsychiatric examination, 11 (55%) patients had neurological sequelae, 18 (90%) patients had psychiatric issues, and 14 (70%) patients had two or more neuropsychiatric problems simultaneously. One (5%) patient had mitral valve insufficiency. Twelve patients (60%) had hearing loss. According to visual examination, 6 (30%) patients had refraction problem, 4 (20%) had cataract, and 1 (5%) had dry eye.
Conclusion
Careful monitoring of long-term side effects is important for improving the quality of life of medulloblastoma patients. Besides endocrinological and other somatic sequelae of the disease and treatment, increased neuropsychiatric problems showed us that only cure is not the issue while treating childhood medulloblastoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37698649</pmid><doi>10.1007/s00381-023-06146-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0394-6219</orcidid></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Cerebellar Neoplasms - radiotherapy Child Disease Progression Female Growth Hormone Humans Male Medicine Medicine & Public Health Medulloblastoma - pathology Neurosciences Neurosurgery Original Article Quality of Life Survivors Young Adult |
| title | Late effects of medulloblastoma treatment: multidisciplinary approach of survivors |
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