Subchronic toxicity evaluation of Huobahuagen extract and plasma metabolic profiling analysis combined with conventional pathology methods

Huobahua, namely, Tripterygium hypoglaucum (Levl.) Hutch, known as a traditional Chinese herbal medicine, especially its underground parts, has been widely developed into several Tripterygium agents for the treatment of rheumatoid arthritis and other autoimmune diseases. It has sparked wide public c...

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Veröffentlicht in:	Journal of applied toxicology 2024-02, Vol.44 (2), p.201-215
Hauptverfasser:	Long, Chengyan, He, Peilin, Tu, Ruxia, Song, Xiaoxian, Li, Henghua, Huang, Wentao, Liu, Jianyi, Zhang, Li, Guo, Yanlei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Autoimmune diseases Biosynthesis Detoxification Epididymis Glutathione Herbal medicine histopathology Huobahuagen extract Male Males Medicine, Chinese Traditional Metabolic disorders Metabolism Metabolomics Metabolomics - methods Oral administration Pathology Phenylalanine Plant Extracts - toxicity Plasma plasma metabolomics Public concern Rats Rheumatoid arthritis serum biochemistry subchronic toxicity Testis Testosterone Toxicity Toxicity Tests, Subchronic Traditional Chinese medicine Tripterygium Tripterygium - chemistry Tryptophan Urinalysis
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