Changes in the fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake
The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gu...
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| Veröffentlicht in: | Physiological genomics 2023-12, Vol.55 (12), p.647-653 |
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| creator | Kageyama, Suzumi Inoue, Rikako Park, Jonguk Hosomi, Koji Yumioka, Hitomi Suka, Tomo Teramoto, Kazuaki Syauki, A. Yasmin Doi, Miki Sakaue, Haruka Miyake, Miyuu Mizuguchi, Kenji Kunisawa, Jun Irie, Yasuyuki |
| description | The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gut microbiome returned to its original state. This is the first pilot study to examine both the changes in the gut microbiome and their sustainability after MR-Amazake intake.
The aim of the present study was to investigate changes in the gut microbiome both during and after consumption of malted rice amazake (MR-Amazake), a fermented food from Japan, in-home healthcare patients with disabilities, including patients with severe motor and intellectual disabilities. We monitored 12 patients who consumed MR-Amazake for 6 wk and investigated them before and after the intervention as well as 6 wk after the end of intake to compare their physical condition, diet, type of their medication, constipation assessment scale, and analysis of their comprehensive fecal microbiome using 16S rRNA sequencing. Their constipation symptoms were significantly alleviated, and principal coordinate analysis revealed that 30% of patients showed significant changes in the gut microbiome after MR-Amazake ingestion. Furthermore, Bifidobacterium was strongly associated with these changes. These changes were observed only during MR-Amazake intake; the original gut microbiome was restored when MR-Amazake intake was discontinued. These results suggest that 6 wk is a reasonable period of time for MR-Amazake to change the human gut microbiome and that continuous consumption of MR-Amazake is required to sustain such changes.
NEW & NOTEWORTHY The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gut microbiome returned to its original state. This is the first pilot study to examine both the changes in the gut microbiome and their sustainability after MR-Amazake intake. |
| doi_str_mv | 10.1152/physiolgenomics.00062.2023 |
| format | Article |
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The aim of the present study was to investigate changes in the gut microbiome both during and after consumption of malted rice amazake (MR-Amazake), a fermented food from Japan, in-home healthcare patients with disabilities, including patients with severe motor and intellectual disabilities. We monitored 12 patients who consumed MR-Amazake for 6 wk and investigated them before and after the intervention as well as 6 wk after the end of intake to compare their physical condition, diet, type of their medication, constipation assessment scale, and analysis of their comprehensive fecal microbiome using 16S rRNA sequencing. Their constipation symptoms were significantly alleviated, and principal coordinate analysis revealed that 30% of patients showed significant changes in the gut microbiome after MR-Amazake ingestion. Furthermore, Bifidobacterium was strongly associated with these changes. These changes were observed only during MR-Amazake intake; the original gut microbiome was restored when MR-Amazake intake was discontinued. These results suggest that 6 wk is a reasonable period of time for MR-Amazake to change the human gut microbiome and that continuous consumption of MR-Amazake is required to sustain such changes.
NEW & NOTEWORTHY The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gut microbiome returned to its original state. This is the first pilot study to examine both the changes in the gut microbiome and their sustainability after MR-Amazake intake.</description><identifier>ISSN: 1094-8341</identifier><identifier>EISSN: 1531-2267</identifier><identifier>DOI: 10.1152/physiolgenomics.00062.2023</identifier><language>eng</language><publisher>Bethesda: American Physiological Society</publisher><subject>Constipation ; Fermented food ; Health care ; Intellectual disabilities ; Intestinal microflora ; Microbiomes ; rRNA 16S</subject><ispartof>Physiological genomics, 2023-12, Vol.55 (12), p.647-653</ispartof><rights>Copyright American Physiological Society Dec 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c319t-88861146da8901fad444500a42267523aef2ce7191ae2c28e98383319aac82ed3</cites><orcidid>0000-0002-1723-2444 ; 0000-0003-4901-1125 ; 0000-0001-6815-9139 ; 0000-0003-3021-7078 ; 0000-0003-4872-385X ; 0009-0001-9881-4322 ; 0000-0002-2928-1278 ; 0000-0002-7798-9510</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3040,27929,27930</link.rule.ids></links><search><creatorcontrib>Kageyama, Suzumi</creatorcontrib><creatorcontrib>Inoue, Rikako</creatorcontrib><creatorcontrib>Park, Jonguk</creatorcontrib><creatorcontrib>Hosomi, Koji</creatorcontrib><creatorcontrib>Yumioka, Hitomi</creatorcontrib><creatorcontrib>Suka, Tomo</creatorcontrib><creatorcontrib>Teramoto, Kazuaki</creatorcontrib><creatorcontrib>Syauki, A. Yasmin</creatorcontrib><creatorcontrib>Doi, Miki</creatorcontrib><creatorcontrib>Sakaue, Haruka</creatorcontrib><creatorcontrib>Miyake, Miyuu</creatorcontrib><creatorcontrib>Mizuguchi, Kenji</creatorcontrib><creatorcontrib>Kunisawa, Jun</creatorcontrib><creatorcontrib>Irie, Yasuyuki</creatorcontrib><title>Changes in the fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake</title><title>Physiological genomics</title><description>The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gut microbiome returned to its original state. This is the first pilot study to examine both the changes in the gut microbiome and their sustainability after MR-Amazake intake.
The aim of the present study was to investigate changes in the gut microbiome both during and after consumption of malted rice amazake (MR-Amazake), a fermented food from Japan, in-home healthcare patients with disabilities, including patients with severe motor and intellectual disabilities. We monitored 12 patients who consumed MR-Amazake for 6 wk and investigated them before and after the intervention as well as 6 wk after the end of intake to compare their physical condition, diet, type of their medication, constipation assessment scale, and analysis of their comprehensive fecal microbiome using 16S rRNA sequencing. Their constipation symptoms were significantly alleviated, and principal coordinate analysis revealed that 30% of patients showed significant changes in the gut microbiome after MR-Amazake ingestion. Furthermore, Bifidobacterium was strongly associated with these changes. These changes were observed only during MR-Amazake intake; the original gut microbiome was restored when MR-Amazake intake was discontinued. These results suggest that 6 wk is a reasonable period of time for MR-Amazake to change the human gut microbiome and that continuous consumption of MR-Amazake is required to sustain such changes.
NEW & NOTEWORTHY The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gut microbiome returned to its original state. This is the first pilot study to examine both the changes in the gut microbiome and their sustainability after MR-Amazake intake.</description><subject>Constipation</subject><subject>Fermented food</subject><subject>Health care</subject><subject>Intellectual disabilities</subject><subject>Intestinal microflora</subject><subject>Microbiomes</subject><subject>rRNA 16S</subject><issn>1094-8341</issn><issn>1531-2267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkctKxTAQhosoeH2HoBs3PWaSXlJ3cvAGB9zouozp9DTaNjVJEcWHN1VXrmYYvvnn8ifJKfAVQC4upu7DG9tvabSD0X7FOS_ESnAhd5IDyCWkQhTlbsx5laVKZrCfHHr_wjlkpcoPkq91h-OWPDMjCx2xljT2bDsHFvWcfTZ2IGZb1i2xI-xDp9ERmzAYGoNn7yZ0rDEen01vYs1HGWfnbce0Hf08TMHYcVEYYi81zBlNDAf8xFc6TvZa7D2d_MWj5Onm-nF9l24ebu_XV5tUS6hCqpQqALKiQVVxaLHJsiznHLPltlxIpFZoKqECJKGFokpJJWMrolaCGnmUnP_qTs6-zeRDPRivqe9xJDv7WqhCloWCsoro2T_0xc5ujNtFqgKIA6WI1OUvFV_kvaO2npwZ0H3UwOvFmPqfMfWPMfVijPwGjhyIGA</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Kageyama, Suzumi</creator><creator>Inoue, Rikako</creator><creator>Park, Jonguk</creator><creator>Hosomi, Koji</creator><creator>Yumioka, Hitomi</creator><creator>Suka, Tomo</creator><creator>Teramoto, Kazuaki</creator><creator>Syauki, A. 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Yasmin ; Doi, Miki ; Sakaue, Haruka ; Miyake, Miyuu ; Mizuguchi, Kenji ; Kunisawa, Jun ; Irie, Yasuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-88861146da8901fad444500a42267523aef2ce7191ae2c28e98383319aac82ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Constipation</topic><topic>Fermented food</topic><topic>Health care</topic><topic>Intellectual disabilities</topic><topic>Intestinal microflora</topic><topic>Microbiomes</topic><topic>rRNA 16S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kageyama, Suzumi</creatorcontrib><creatorcontrib>Inoue, Rikako</creatorcontrib><creatorcontrib>Park, Jonguk</creatorcontrib><creatorcontrib>Hosomi, Koji</creatorcontrib><creatorcontrib>Yumioka, Hitomi</creatorcontrib><creatorcontrib>Suka, Tomo</creatorcontrib><creatorcontrib>Teramoto, Kazuaki</creatorcontrib><creatorcontrib>Syauki, A. Yasmin</creatorcontrib><creatorcontrib>Doi, Miki</creatorcontrib><creatorcontrib>Sakaue, Haruka</creatorcontrib><creatorcontrib>Miyake, Miyuu</creatorcontrib><creatorcontrib>Mizuguchi, Kenji</creatorcontrib><creatorcontrib>Kunisawa, Jun</creatorcontrib><creatorcontrib>Irie, Yasuyuki</creatorcontrib><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kageyama, Suzumi</au><au>Inoue, Rikako</au><au>Park, Jonguk</au><au>Hosomi, Koji</au><au>Yumioka, Hitomi</au><au>Suka, Tomo</au><au>Teramoto, Kazuaki</au><au>Syauki, A. Yasmin</au><au>Doi, Miki</au><au>Sakaue, Haruka</au><au>Miyake, Miyuu</au><au>Mizuguchi, Kenji</au><au>Kunisawa, Jun</au><au>Irie, Yasuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake</atitle><jtitle>Physiological genomics</jtitle><date>2023-12-01</date><risdate>2023</risdate><volume>55</volume><issue>12</issue><spage>647</spage><epage>653</epage><pages>647-653</pages><issn>1094-8341</issn><eissn>1531-2267</eissn><abstract>The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gut microbiome returned to its original state. This is the first pilot study to examine both the changes in the gut microbiome and their sustainability after MR-Amazake intake.
The aim of the present study was to investigate changes in the gut microbiome both during and after consumption of malted rice amazake (MR-Amazake), a fermented food from Japan, in-home healthcare patients with disabilities, including patients with severe motor and intellectual disabilities. We monitored 12 patients who consumed MR-Amazake for 6 wk and investigated them before and after the intervention as well as 6 wk after the end of intake to compare their physical condition, diet, type of their medication, constipation assessment scale, and analysis of their comprehensive fecal microbiome using 16S rRNA sequencing. Their constipation symptoms were significantly alleviated, and principal coordinate analysis revealed that 30% of patients showed significant changes in the gut microbiome after MR-Amazake ingestion. Furthermore, Bifidobacterium was strongly associated with these changes. These changes were observed only during MR-Amazake intake; the original gut microbiome was restored when MR-Amazake intake was discontinued. These results suggest that 6 wk is a reasonable period of time for MR-Amazake to change the human gut microbiome and that continuous consumption of MR-Amazake is required to sustain such changes.
NEW & NOTEWORTHY The consumption of malted rice amazake (MR-Amazake) showed significant changes in the gut microbiome according to principal coordinate analysis in some home healthcare patients with disabilities, including those with severe motor and intellectual disabilities. After discontinuation of intake, the gut microbiome returned to its original state. This is the first pilot study to examine both the changes in the gut microbiome and their sustainability after MR-Amazake intake.</abstract><cop>Bethesda</cop><pub>American Physiological Society</pub><doi>10.1152/physiolgenomics.00062.2023</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1723-2444</orcidid><orcidid>https://orcid.org/0000-0003-4901-1125</orcidid><orcidid>https://orcid.org/0000-0001-6815-9139</orcidid><orcidid>https://orcid.org/0000-0003-3021-7078</orcidid><orcidid>https://orcid.org/0000-0003-4872-385X</orcidid><orcidid>https://orcid.org/0009-0001-9881-4322</orcidid><orcidid>https://orcid.org/0000-0002-2928-1278</orcidid><orcidid>https://orcid.org/0000-0002-7798-9510</orcidid><oa>free_for_read</oa></addata></record> |
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| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Constipation Fermented food Health care Intellectual disabilities Intestinal microflora Microbiomes rRNA 16S |
| title | Changes in the fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake |
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