Alzheimer's disease, amyloid-b peptides and ubiquitin-proteasome system: Therapeutic perspectives

Alzheimer's disease, amyloid-b peptides and ubiquitin-proteasome system: Therapeutic perspectives

The Alzheimer's disease - an age-related neurodegenerative disorder leading to a progressive cognitive impairment - is characterized by an intracerebral accumulation of soluble β-amyloid (Aβ) oligomers, followed by the appearance of abnormally ubiquitinylated neurofibrillary tangles - a process...

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Veröffentlicht in:M.S. Médecine sciences 2023-08, Vol.39 (8-9), p.643-649
Hauptverfasser: Simon, Philippe Yves Rémy, Bus, Johanna, David, Renaud
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description The Alzheimer's disease - an age-related neurodegenerative disorder leading to a progressive cognitive impairment - is characterized by an intracerebral accumulation of soluble β-amyloid (Aβ) oligomers, followed by the appearance of abnormally ubiquitinylated neurofibrillary tangles - a process associated with a chronic inflammation. The systematic presence of ubiquitinylated inclusions reflects a decrease in the proteasome activity due to (and contributing to) the presence of Aβ oligomers - a central dysfunction in the etiology of the disease. The involvement of the ubiquitin-proteasome system opens new therapeutic perspectives for both prevention and treatment.
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title Alzheimer's disease, amyloid-b peptides and ubiquitin-proteasome system: Therapeutic perspectives
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