Novel chlorin e6-based conjugates of tyrosine kinase inhibitors: Synthesis and photobiological evaluation as potent photosensitizers for photodynamic therapy

Since tyrosine kinase inhibitor (TKI) could reverse ABCG2-mediated drug-resistance, novel chlorin e6-based conjugates of Dasatinib and Imatinib as photosensitizer (PS) were designed and synthesized. The results demonstrated that conjugate 10b showed strongest phototoxicity against HepG2 and B16-F10 ...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-12, Vol.261, p.115787-115787, Article 115787
Hauptverfasser:	Huang, Fei, Li, Yu, Zhang, Xing-Jie, Lin, Mei-Yu, Han, Gui-Yan, Lin, Hui-Ying, Lin, Hui-Yun, Miao, Zhenyuan, Li, Bu-Hong, Sheng, Chun-Quan, Yao, Jian-Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 Chlorin e6 Photodynamic therapy (PDT) Photosensitizer Tyrosine kinase inhibitors (TKI)
Online-Zugang:	Volltext
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