OGD/R‐induced ferroptosis and pyroptosis in retinal pigment epithelium cells: Role of PLD1 and PLD2 modulation

This study investigated the role of phospholipase D (PLD) in retinal ischemia–reperfusion (I/R) injury using an oxygen‐glucose deprivation/reperfusion (OGD/R) model commonly used in retinal I/R injury research. To create an in vitro cellular I/R model, pharmacological inhibitors and small interferin...

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Veröffentlicht in:	Cell biochemistry and function 2023-12, Vol.41 (8), p.1162-1173
Hauptverfasser:	Park, Sun Young, Kang, He Mi, Park, Geuntae, Oh, Jin‐Woo, Choi, Young‐Whan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Caspase-1 Cell death Cellular stress response Cytokines Damage Degeneration Epithelium Ferroptosis Glutathione Inflammasomes Inflammation Ischemia Isoforms Lipid peroxidation Lipids Medical treatment OGD/R Oxidative stress Oxygen Peroxidation Phospholipase Phospholipase D Pigments PLD Pyroptosis Reactive oxygen species Reperfusion Retina Retinal pigment epithelium Signal transduction siRNA Superoxide dismutase Therapeutic targets
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