Generation of Cannabigerolic Acid Derivatives and Their Precursors by Using the Promiscuity of the Aromatic Prenyltransferase NphB

NphB is an aromatic prenyltransferase with high promiscuity for phenolics including flavonoids, isoflavonoids, and plant polyketides. It has been demonstrated that cannabigerolic acid is successfully formed by the reaction catalysed by NphB using geranyl diphosphate and olivetolic acid as substrates...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2023-11, Vol.24 (22), p.e202300441-e202300441
Hauptverfasser:	Spitzer, Saskia, Wloka, Jasmin, Pietruszka, Jörg, Kayser, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biosynthesis Cannabinoids Cannabinoids - metabolism Dihydroxybenzoic acid Dimethylallyltranstransferase - chemistry Flavonoids Isoflavonoids Molecular chains Phenols Polyketides Salicylates - metabolism Substrate Specificity Substrates
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