Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies
Abstract Background The role of genetic background underlying the disparity of relative risk of smoking and lung cancer between European populations and East Asians remains unclear. Methods To assess the role of ethnic differences in genetic factors associated with smoking-related risk of lung cance...
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| Veröffentlicht in: | International journal of epidemiology 2023-12, Vol.52 (6), p.1815-1825 |
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| creator | Zhu, Meng Lv, Jun Huang, Yanqian Ma, Hongxia Li, Ni Wei, Xiaoxia Ji, Mengmeng Ma, Zhimin Song, Ci Wang, Cheng Dai, Juncheng Tan, Fengwei Guo, Yu Walters, Robin Millwood, Iona Y Hung, Rayjean J Christiani, David C Yu, Canqing Jin, Guangfu Chen, Zhengming Wei, Qingyi Amos, Christopher I Hu, Zhibin Li, Liming Shen, Hongbing |
| description | Abstract
Background
The role of genetic background underlying the disparity of relative risk of smoking and lung cancer between European populations and East Asians remains unclear.
Methods
To assess the role of ethnic differences in genetic factors associated with smoking-related risk of lung cancer, we first constructed ethnic-specific polygenic risk scores (PRSs) to quantify individual genetic risk of lung cancer in Chinese and European populations. Then, we compared genetic risk and smoking as well as their interactions on lung cancer between two cohorts, including the China Kadoorie Biobank (CKB) and the UK Biobank (UKB). We also evaluated the absolute risk reduction over a 5-year period.
Results
Differences in compositions and association effects were observed between the Chinese-specific PRSs and European-specific PRSs, especially for smoking-related loci. The PRSs were consistently associated with lung cancer risk, but stronger associations were observed in smokers of the UKB [hazard ratio (HR) 1.26 vs 1.15, P = 0.028]. A significant interaction between genetic risk and smoking on lung cancer was observed in the UKB (RERI, 11.39 (95% CI, 7.01–17.94)], but not in the CKB. Obvious higher absolute risk was observed in nonsmokers of the CKB, and a greater absolute risk reduction was found in the UKB (10.95 vs 7.12 per 1000 person-years, P |
| doi_str_mv | 10.1093/ije/dyad118 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2863304507</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ije/dyad118</oup_id><sourcerecordid>2863304507</sourcerecordid><originalsourceid>FETCH-LOGICAL-c320t-e28f1e571af17b36da20f95c733dbe091575d689d332cf6243e21f89e40484093</originalsourceid><addsrcrecordid>eNp9kEtLAzEYRYMotj5W7iUrEWRsMskkM-6k1AcU3OhShmnypU07L5OM0n9vpNWlqwuXw-VyELqg5JaSgk3sGiZ6W2lK8wM0plzwhIk8O0RjwghJMinpCJ14vyaEcs6LYzRiUkiRczlG77Owaq3C2hoDDloFHncGL6GFEGtn_QZXrca-6Ta2XWLb4nqIqaqIujscvjrcu873oIL9BKy6VecC9mHQFvwZOjJV7eF8n6fo7WH2On1K5i-Pz9P7eaJYSkICaW4oZJJWhsoFE7pKiSkyJRnTCyAFzWSmRV5oxlJlRMoZpNTkBXDCcx4dnKLr3W688jGAD2VjvYK6rlroBl-muWCM8IzIiN7sUBVfewem7J1tKrctKSl_fJbRZ7n3GenL_fCwaED_sb8CI3C1A7qh_3fpG4Xtfwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2863304507</pqid></control><display><type>article</type><title>Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Zhu, Meng ; Lv, Jun ; Huang, Yanqian ; Ma, Hongxia ; Li, Ni ; Wei, Xiaoxia ; Ji, Mengmeng ; Ma, Zhimin ; Song, Ci ; Wang, Cheng ; Dai, Juncheng ; Tan, Fengwei ; Guo, Yu ; Walters, Robin ; Millwood, Iona Y ; Hung, Rayjean J ; Christiani, David C ; Yu, Canqing ; Jin, Guangfu ; Chen, Zhengming ; Wei, Qingyi ; Amos, Christopher I ; Hu, Zhibin ; Li, Liming ; Shen, Hongbing</creator><creatorcontrib>Zhu, Meng ; Lv, Jun ; Huang, Yanqian ; Ma, Hongxia ; Li, Ni ; Wei, Xiaoxia ; Ji, Mengmeng ; Ma, Zhimin ; Song, Ci ; Wang, Cheng ; Dai, Juncheng ; Tan, Fengwei ; Guo, Yu ; Walters, Robin ; Millwood, Iona Y ; Hung, Rayjean J ; Christiani, David C ; Yu, Canqing ; Jin, Guangfu ; Chen, Zhengming ; Wei, Qingyi ; Amos, Christopher I ; Hu, Zhibin ; Li, Liming ; Shen, Hongbing</creatorcontrib><description>Abstract
Background
The role of genetic background underlying the disparity of relative risk of smoking and lung cancer between European populations and East Asians remains unclear.
Methods
To assess the role of ethnic differences in genetic factors associated with smoking-related risk of lung cancer, we first constructed ethnic-specific polygenic risk scores (PRSs) to quantify individual genetic risk of lung cancer in Chinese and European populations. Then, we compared genetic risk and smoking as well as their interactions on lung cancer between two cohorts, including the China Kadoorie Biobank (CKB) and the UK Biobank (UKB). We also evaluated the absolute risk reduction over a 5-year period.
Results
Differences in compositions and association effects were observed between the Chinese-specific PRSs and European-specific PRSs, especially for smoking-related loci. The PRSs were consistently associated with lung cancer risk, but stronger associations were observed in smokers of the UKB [hazard ratio (HR) 1.26 vs 1.15, P = 0.028]. A significant interaction between genetic risk and smoking on lung cancer was observed in the UKB (RERI, 11.39 (95% CI, 7.01–17.94)], but not in the CKB. Obvious higher absolute risk was observed in nonsmokers of the CKB, and a greater absolute risk reduction was found in the UKB (10.95 vs 7.12 per 1000 person-years, P <0.001) by comparing heavy smokers with nonsmokers, especially for those at high genetic risk.
Conclusions
Ethnic differences in genetic factors and the high incidence of lung cancer in nonsmokers of East Asian ethnicity were involved in the disparity of smoking-related risk of lung cancer.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyad118</identifier><identifier>PMID: 37676847</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Genetic Risk Score ; Humans ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Prospective Studies ; Risk Factors ; Smoking - adverse effects ; Smoking - genetics ; Tobacco Smoking</subject><ispartof>International journal of epidemiology, 2023-12, Vol.52 (6), p.1815-1825</ispartof><rights>The Author(s) 2023; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association 2023</rights><rights>The Author(s) 2023; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-e28f1e571af17b36da20f95c733dbe091575d689d332cf6243e21f89e40484093</citedby><cites>FETCH-LOGICAL-c320t-e28f1e571af17b36da20f95c733dbe091575d689d332cf6243e21f89e40484093</cites><orcidid>0000-0001-7916-3870 ; 0000-0002-0019-0014 ; 0000-0002-8277-5234 ; 0000-0002-2462-9693 ; 0000-0003-3560-6216 ; 0000-0001-5530-7745 ; 0000-0002-2581-5906</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1579,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37676847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Meng</creatorcontrib><creatorcontrib>Lv, Jun</creatorcontrib><creatorcontrib>Huang, Yanqian</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Li, Ni</creatorcontrib><creatorcontrib>Wei, Xiaoxia</creatorcontrib><creatorcontrib>Ji, Mengmeng</creatorcontrib><creatorcontrib>Ma, Zhimin</creatorcontrib><creatorcontrib>Song, Ci</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Dai, Juncheng</creatorcontrib><creatorcontrib>Tan, Fengwei</creatorcontrib><creatorcontrib>Guo, Yu</creatorcontrib><creatorcontrib>Walters, Robin</creatorcontrib><creatorcontrib>Millwood, Iona Y</creatorcontrib><creatorcontrib>Hung, Rayjean J</creatorcontrib><creatorcontrib>Christiani, David C</creatorcontrib><creatorcontrib>Yu, Canqing</creatorcontrib><creatorcontrib>Jin, Guangfu</creatorcontrib><creatorcontrib>Chen, Zhengming</creatorcontrib><creatorcontrib>Wei, Qingyi</creatorcontrib><creatorcontrib>Amos, Christopher I</creatorcontrib><creatorcontrib>Hu, Zhibin</creatorcontrib><creatorcontrib>Li, Liming</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><title>Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>Abstract
Background
The role of genetic background underlying the disparity of relative risk of smoking and lung cancer between European populations and East Asians remains unclear.
Methods
To assess the role of ethnic differences in genetic factors associated with smoking-related risk of lung cancer, we first constructed ethnic-specific polygenic risk scores (PRSs) to quantify individual genetic risk of lung cancer in Chinese and European populations. Then, we compared genetic risk and smoking as well as their interactions on lung cancer between two cohorts, including the China Kadoorie Biobank (CKB) and the UK Biobank (UKB). We also evaluated the absolute risk reduction over a 5-year period.
Results
Differences in compositions and association effects were observed between the Chinese-specific PRSs and European-specific PRSs, especially for smoking-related loci. The PRSs were consistently associated with lung cancer risk, but stronger associations were observed in smokers of the UKB [hazard ratio (HR) 1.26 vs 1.15, P = 0.028]. A significant interaction between genetic risk and smoking on lung cancer was observed in the UKB (RERI, 11.39 (95% CI, 7.01–17.94)], but not in the CKB. Obvious higher absolute risk was observed in nonsmokers of the CKB, and a greater absolute risk reduction was found in the UKB (10.95 vs 7.12 per 1000 person-years, P <0.001) by comparing heavy smokers with nonsmokers, especially for those at high genetic risk.
Conclusions
Ethnic differences in genetic factors and the high incidence of lung cancer in nonsmokers of East Asian ethnicity were involved in the disparity of smoking-related risk of lung cancer.</description><subject>Genetic Risk Score</subject><subject>Humans</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - genetics</subject><subject>Tobacco Smoking</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEYRYMotj5W7iUrEWRsMskkM-6k1AcU3OhShmnypU07L5OM0n9vpNWlqwuXw-VyELqg5JaSgk3sGiZ6W2lK8wM0plzwhIk8O0RjwghJMinpCJ14vyaEcs6LYzRiUkiRczlG77Owaq3C2hoDDloFHncGL6GFEGtn_QZXrca-6Ta2XWLb4nqIqaqIujscvjrcu873oIL9BKy6VecC9mHQFvwZOjJV7eF8n6fo7WH2On1K5i-Pz9P7eaJYSkICaW4oZJJWhsoFE7pKiSkyJRnTCyAFzWSmRV5oxlJlRMoZpNTkBXDCcx4dnKLr3W688jGAD2VjvYK6rlroBl-muWCM8IzIiN7sUBVfewem7J1tKrctKSl_fJbRZ7n3GenL_fCwaED_sb8CI3C1A7qh_3fpG4Xtfwg</recordid><startdate>20231225</startdate><enddate>20231225</enddate><creator>Zhu, Meng</creator><creator>Lv, Jun</creator><creator>Huang, Yanqian</creator><creator>Ma, Hongxia</creator><creator>Li, Ni</creator><creator>Wei, Xiaoxia</creator><creator>Ji, Mengmeng</creator><creator>Ma, Zhimin</creator><creator>Song, Ci</creator><creator>Wang, Cheng</creator><creator>Dai, Juncheng</creator><creator>Tan, Fengwei</creator><creator>Guo, Yu</creator><creator>Walters, Robin</creator><creator>Millwood, Iona Y</creator><creator>Hung, Rayjean J</creator><creator>Christiani, David C</creator><creator>Yu, Canqing</creator><creator>Jin, Guangfu</creator><creator>Chen, Zhengming</creator><creator>Wei, Qingyi</creator><creator>Amos, Christopher I</creator><creator>Hu, Zhibin</creator><creator>Li, Liming</creator><creator>Shen, Hongbing</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7916-3870</orcidid><orcidid>https://orcid.org/0000-0002-0019-0014</orcidid><orcidid>https://orcid.org/0000-0002-8277-5234</orcidid><orcidid>https://orcid.org/0000-0002-2462-9693</orcidid><orcidid>https://orcid.org/0000-0003-3560-6216</orcidid><orcidid>https://orcid.org/0000-0001-5530-7745</orcidid><orcidid>https://orcid.org/0000-0002-2581-5906</orcidid></search><sort><creationdate>20231225</creationdate><title>Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies</title><author>Zhu, Meng ; Lv, Jun ; Huang, Yanqian ; Ma, Hongxia ; Li, Ni ; Wei, Xiaoxia ; Ji, Mengmeng ; Ma, Zhimin ; Song, Ci ; Wang, Cheng ; Dai, Juncheng ; Tan, Fengwei ; Guo, Yu ; Walters, Robin ; Millwood, Iona Y ; Hung, Rayjean J ; Christiani, David C ; Yu, Canqing ; Jin, Guangfu ; Chen, Zhengming ; Wei, Qingyi ; Amos, Christopher I ; Hu, Zhibin ; Li, Liming ; Shen, Hongbing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-e28f1e571af17b36da20f95c733dbe091575d689d332cf6243e21f89e40484093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Genetic Risk Score</topic><topic>Humans</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - genetics</topic><topic>Tobacco Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Meng</creatorcontrib><creatorcontrib>Lv, Jun</creatorcontrib><creatorcontrib>Huang, Yanqian</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Li, Ni</creatorcontrib><creatorcontrib>Wei, Xiaoxia</creatorcontrib><creatorcontrib>Ji, Mengmeng</creatorcontrib><creatorcontrib>Ma, Zhimin</creatorcontrib><creatorcontrib>Song, Ci</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Dai, Juncheng</creatorcontrib><creatorcontrib>Tan, Fengwei</creatorcontrib><creatorcontrib>Guo, Yu</creatorcontrib><creatorcontrib>Walters, Robin</creatorcontrib><creatorcontrib>Millwood, Iona Y</creatorcontrib><creatorcontrib>Hung, Rayjean J</creatorcontrib><creatorcontrib>Christiani, David C</creatorcontrib><creatorcontrib>Yu, Canqing</creatorcontrib><creatorcontrib>Jin, Guangfu</creatorcontrib><creatorcontrib>Chen, Zhengming</creatorcontrib><creatorcontrib>Wei, Qingyi</creatorcontrib><creatorcontrib>Amos, Christopher I</creatorcontrib><creatorcontrib>Hu, Zhibin</creatorcontrib><creatorcontrib>Li, Liming</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Meng</au><au>Lv, Jun</au><au>Huang, Yanqian</au><au>Ma, Hongxia</au><au>Li, Ni</au><au>Wei, Xiaoxia</au><au>Ji, Mengmeng</au><au>Ma, Zhimin</au><au>Song, Ci</au><au>Wang, Cheng</au><au>Dai, Juncheng</au><au>Tan, Fengwei</au><au>Guo, Yu</au><au>Walters, Robin</au><au>Millwood, Iona Y</au><au>Hung, Rayjean J</au><au>Christiani, David C</au><au>Yu, Canqing</au><au>Jin, Guangfu</au><au>Chen, Zhengming</au><au>Wei, Qingyi</au><au>Amos, Christopher I</au><au>Hu, Zhibin</au><au>Li, Liming</au><au>Shen, Hongbing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2023-12-25</date><risdate>2023</risdate><volume>52</volume><issue>6</issue><spage>1815</spage><epage>1825</epage><pages>1815-1825</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>Abstract
Background
The role of genetic background underlying the disparity of relative risk of smoking and lung cancer between European populations and East Asians remains unclear.
Methods
To assess the role of ethnic differences in genetic factors associated with smoking-related risk of lung cancer, we first constructed ethnic-specific polygenic risk scores (PRSs) to quantify individual genetic risk of lung cancer in Chinese and European populations. Then, we compared genetic risk and smoking as well as their interactions on lung cancer between two cohorts, including the China Kadoorie Biobank (CKB) and the UK Biobank (UKB). We also evaluated the absolute risk reduction over a 5-year period.
Results
Differences in compositions and association effects were observed between the Chinese-specific PRSs and European-specific PRSs, especially for smoking-related loci. The PRSs were consistently associated with lung cancer risk, but stronger associations were observed in smokers of the UKB [hazard ratio (HR) 1.26 vs 1.15, P = 0.028]. A significant interaction between genetic risk and smoking on lung cancer was observed in the UKB (RERI, 11.39 (95% CI, 7.01–17.94)], but not in the CKB. Obvious higher absolute risk was observed in nonsmokers of the CKB, and a greater absolute risk reduction was found in the UKB (10.95 vs 7.12 per 1000 person-years, P <0.001) by comparing heavy smokers with nonsmokers, especially for those at high genetic risk.
Conclusions
Ethnic differences in genetic factors and the high incidence of lung cancer in nonsmokers of East Asian ethnicity were involved in the disparity of smoking-related risk of lung cancer.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>37676847</pmid><doi>10.1093/ije/dyad118</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7916-3870</orcidid><orcidid>https://orcid.org/0000-0002-0019-0014</orcidid><orcidid>https://orcid.org/0000-0002-8277-5234</orcidid><orcidid>https://orcid.org/0000-0002-2462-9693</orcidid><orcidid>https://orcid.org/0000-0003-3560-6216</orcidid><orcidid>https://orcid.org/0000-0001-5530-7745</orcidid><orcidid>https://orcid.org/0000-0002-2581-5906</orcidid></addata></record> |
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| ispartof | International journal of epidemiology, 2023-12, Vol.52 (6), p.1815-1825 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Genetic Risk Score Humans Lung Neoplasms - epidemiology Lung Neoplasms - genetics Prospective Studies Risk Factors Smoking - adverse effects Smoking - genetics Tobacco Smoking |
| title | Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies |
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