Rationale and design of the INVICTUS Registry: (Multicenter Registry of Invasive and Non-Invasive imaging modalities to compare Coronary Computed Tomography Angiography, Intravascular Ultrasound and Optical Coherence Tomography for the determination of Severity, Volume and Type of coronary atherosclerosiS)
Coronary CT angiography (CCTA) is a first-line noninvasive imaging modality for evaluating coronary artery disease (CAD). Recent advances in CCTA technology enabled semi-automated detection of coronary arteries and atherosclerosis. However, there have been to date no large-scale validation studies o...
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| Veröffentlicht in: | Journal of cardiovascular computed tomography 2023-11, Vol.17 (6), p.401-406 |
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| creator | Nakanishi, Rine Okubo, Ryo Sobue, Yoshihiro Kaneko, Umihiko Sato, Hideyuki Fujimoto, Shinichiro Nozaki, Yui Kajiya, Takashi Miyoshi, Toru Ichikawa, Keishi Abe, Mitsunori Kitagawa, Toshiro Ikenaga, Hiroki Osawa, Kazuhiro Saji, Mike Iguchi, Nobuo Nakazawa, Gaku Takahashi, Kuniaki Ijich, Takeshi Mikamo, Hiroshi Kurata, Akira Moroi, Masao Iijima, Raisuke Malkasian, Shant Crabtree, Tami Chamie, Daniel Lansky, Alexandra J. Min, James K. Earls, James P. Matsuo, Hitoshi |
| description | Coronary CT angiography (CCTA) is a first-line noninvasive imaging modality for evaluating coronary artery disease (CAD). Recent advances in CCTA technology enabled semi-automated detection of coronary arteries and atherosclerosis. However, there have been to date no large-scale validation studies of automated assessment of coronary atherosclerosis phenotype and coronary artery dimensions by artificial intelligence (AI) compared to current standard invasive imaging.
INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS)-IVUS and optical coherence tomography (OCT). All patients clinically underwent both CCTA and invasive imaging modalities within three months.
Patients data are sent to the core-laboratories to analyze for stenosis severity, plaque characteristics and volume. The variables for CCTA are measured using an AI-based automated software and assessed independently with the variables measured at the imaging core laboratories for IVUS, NIRS-IVUS, and OCT in a blind fashion.
The INVICTUS registry will provide new insights into the diagnostic value of CCTA for determining coronary atherosclerosis phenotype and coronary artery dimensions compared to IVUS, NIRS-IVUS, and OCT. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity. (ClinicalTrials.gov: NCT04066062).
The INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy-IVUS and optical coherence tomography. The main objective of the INVICTUS registry is to achieve a high diagnostic performance of CCTA and a more in-depth evaluation of the phenotype of coronary atherosclerosis. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity. |
| doi_str_mv | 10.1016/j.jcct.2023.08.011 |
| format | Article |
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INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS)-IVUS and optical coherence tomography (OCT). All patients clinically underwent both CCTA and invasive imaging modalities within three months.
Patients data are sent to the core-laboratories to analyze for stenosis severity, plaque characteristics and volume. The variables for CCTA are measured using an AI-based automated software and assessed independently with the variables measured at the imaging core laboratories for IVUS, NIRS-IVUS, and OCT in a blind fashion.
The INVICTUS registry will provide new insights into the diagnostic value of CCTA for determining coronary atherosclerosis phenotype and coronary artery dimensions compared to IVUS, NIRS-IVUS, and OCT. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity. (ClinicalTrials.gov: NCT04066062).
The INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy-IVUS and optical coherence tomography. The main objective of the INVICTUS registry is to achieve a high diagnostic performance of CCTA and a more in-depth evaluation of the phenotype of coronary atherosclerosis. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity.</description><identifier>ISSN: 1934-5925</identifier><identifier>EISSN: 1876-861X</identifier><identifier>DOI: 10.1016/j.jcct.2023.08.011</identifier><identifier>PMID: 37679247</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Artificial Intelligence ; Calcified plaque ; Computed Tomography Angiography ; Coronary Angiography - methods ; Coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; Coronary atherosclerosis ; Coronary computed tomography angiography ; Coronary Vessels - diagnostic imaging ; Humans ; Intravascular ultrasound ; Low density non-calcified plaque ; Near infrared spectroscopy intravascular ultrasound ; Non-calcified plaque ; Optical coherence tomography ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prospective Studies ; Retrospective Studies ; Tomography, Optical Coherence ; Ultrasonography, Interventional - methods</subject><ispartof>Journal of cardiovascular computed tomography, 2023-11, Vol.17 (6), p.401-406</ispartof><rights>2023 Society of Cardiovascular Computed Tomography</rights><rights>Copyright © 2023 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-1431ee2d26b180d6f9ea56413c4032553ccb37f38a1041315f29ea1609a7ed3</citedby><cites>FETCH-LOGICAL-c356t-1431ee2d26b180d6f9ea56413c4032553ccb37f38a1041315f29ea1609a7ed3</cites><orcidid>0000-0002-3558-4347 ; 0000-0002-4237-3927 ; 0000-0003-0657-514X ; 0000-0002-5433-2428 ; 0000-0001-5748-7700 ; 0000-0003-3097-7202 ; 0000-0003-3258-2458 ; 0000-0003-0334-9745 ; 0000-0001-6367-8140 ; 0000-0003-1418-1650 ; 0000-0003-2057-109X ; 0000-0002-9039-3439 ; 0000-0002-1950-7616</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcct.2023.08.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37679247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakanishi, Rine</creatorcontrib><creatorcontrib>Okubo, Ryo</creatorcontrib><creatorcontrib>Sobue, Yoshihiro</creatorcontrib><creatorcontrib>Kaneko, Umihiko</creatorcontrib><creatorcontrib>Sato, Hideyuki</creatorcontrib><creatorcontrib>Fujimoto, Shinichiro</creatorcontrib><creatorcontrib>Nozaki, Yui</creatorcontrib><creatorcontrib>Kajiya, Takashi</creatorcontrib><creatorcontrib>Miyoshi, Toru</creatorcontrib><creatorcontrib>Ichikawa, Keishi</creatorcontrib><creatorcontrib>Abe, Mitsunori</creatorcontrib><creatorcontrib>Kitagawa, Toshiro</creatorcontrib><creatorcontrib>Ikenaga, Hiroki</creatorcontrib><creatorcontrib>Osawa, Kazuhiro</creatorcontrib><creatorcontrib>Saji, Mike</creatorcontrib><creatorcontrib>Iguchi, Nobuo</creatorcontrib><creatorcontrib>Nakazawa, Gaku</creatorcontrib><creatorcontrib>Takahashi, Kuniaki</creatorcontrib><creatorcontrib>Ijich, Takeshi</creatorcontrib><creatorcontrib>Mikamo, Hiroshi</creatorcontrib><creatorcontrib>Kurata, Akira</creatorcontrib><creatorcontrib>Moroi, Masao</creatorcontrib><creatorcontrib>Iijima, Raisuke</creatorcontrib><creatorcontrib>Malkasian, Shant</creatorcontrib><creatorcontrib>Crabtree, Tami</creatorcontrib><creatorcontrib>Chamie, Daniel</creatorcontrib><creatorcontrib>Lansky, Alexandra J.</creatorcontrib><creatorcontrib>Min, James K.</creatorcontrib><creatorcontrib>Earls, James P.</creatorcontrib><creatorcontrib>Matsuo, Hitoshi</creatorcontrib><title>Rationale and design of the INVICTUS Registry: (Multicenter Registry of Invasive and Non-Invasive imaging modalities to compare Coronary Computed Tomography Angiography, Intravascular Ultrasound and Optical Coherence Tomography for the determination of Severity, Volume and Type of coronary atherosclerosiS)</title><title>Journal of cardiovascular computed tomography</title><addtitle>J Cardiovasc Comput Tomogr</addtitle><description>Coronary CT angiography (CCTA) is a first-line noninvasive imaging modality for evaluating coronary artery disease (CAD). Recent advances in CCTA technology enabled semi-automated detection of coronary arteries and atherosclerosis. However, there have been to date no large-scale validation studies of automated assessment of coronary atherosclerosis phenotype and coronary artery dimensions by artificial intelligence (AI) compared to current standard invasive imaging.
INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS)-IVUS and optical coherence tomography (OCT). All patients clinically underwent both CCTA and invasive imaging modalities within three months.
Patients data are sent to the core-laboratories to analyze for stenosis severity, plaque characteristics and volume. The variables for CCTA are measured using an AI-based automated software and assessed independently with the variables measured at the imaging core laboratories for IVUS, NIRS-IVUS, and OCT in a blind fashion.
The INVICTUS registry will provide new insights into the diagnostic value of CCTA for determining coronary atherosclerosis phenotype and coronary artery dimensions compared to IVUS, NIRS-IVUS, and OCT. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity. (ClinicalTrials.gov: NCT04066062).
The INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy-IVUS and optical coherence tomography. The main objective of the INVICTUS registry is to achieve a high diagnostic performance of CCTA and a more in-depth evaluation of the phenotype of coronary atherosclerosis. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity.</description><subject>Artificial Intelligence</subject><subject>Calcified plaque</subject><subject>Computed Tomography Angiography</subject><subject>Coronary Angiography - methods</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary atherosclerosis</subject><subject>Coronary computed tomography angiography</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Humans</subject><subject>Intravascular ultrasound</subject><subject>Low density non-calcified plaque</subject><subject>Near infrared spectroscopy intravascular ultrasound</subject><subject>Non-calcified plaque</subject><subject>Optical coherence tomography</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Ultrasonography, Interventional - 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Academic</collection><jtitle>Journal of cardiovascular computed tomography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakanishi, Rine</au><au>Okubo, Ryo</au><au>Sobue, Yoshihiro</au><au>Kaneko, Umihiko</au><au>Sato, Hideyuki</au><au>Fujimoto, Shinichiro</au><au>Nozaki, Yui</au><au>Kajiya, Takashi</au><au>Miyoshi, Toru</au><au>Ichikawa, Keishi</au><au>Abe, Mitsunori</au><au>Kitagawa, Toshiro</au><au>Ikenaga, Hiroki</au><au>Osawa, Kazuhiro</au><au>Saji, Mike</au><au>Iguchi, Nobuo</au><au>Nakazawa, Gaku</au><au>Takahashi, Kuniaki</au><au>Ijich, Takeshi</au><au>Mikamo, Hiroshi</au><au>Kurata, Akira</au><au>Moroi, Masao</au><au>Iijima, Raisuke</au><au>Malkasian, Shant</au><au>Crabtree, Tami</au><au>Chamie, Daniel</au><au>Lansky, Alexandra J.</au><au>Min, James K.</au><au>Earls, James P.</au><au>Matsuo, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rationale and design of the INVICTUS Registry: (Multicenter Registry of Invasive and Non-Invasive imaging modalities to compare Coronary Computed Tomography Angiography, Intravascular Ultrasound and Optical Coherence Tomography for the determination of Severity, Volume and Type of coronary atherosclerosiS)</atitle><jtitle>Journal of cardiovascular computed tomography</jtitle><addtitle>J Cardiovasc Comput Tomogr</addtitle><date>2023-11</date><risdate>2023</risdate><volume>17</volume><issue>6</issue><spage>401</spage><epage>406</epage><pages>401-406</pages><issn>1934-5925</issn><eissn>1876-861X</eissn><abstract>Coronary CT angiography (CCTA) is a first-line noninvasive imaging modality for evaluating coronary artery disease (CAD). Recent advances in CCTA technology enabled semi-automated detection of coronary arteries and atherosclerosis. However, there have been to date no large-scale validation studies of automated assessment of coronary atherosclerosis phenotype and coronary artery dimensions by artificial intelligence (AI) compared to current standard invasive imaging.
INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS)-IVUS and optical coherence tomography (OCT). All patients clinically underwent both CCTA and invasive imaging modalities within three months.
Patients data are sent to the core-laboratories to analyze for stenosis severity, plaque characteristics and volume. The variables for CCTA are measured using an AI-based automated software and assessed independently with the variables measured at the imaging core laboratories for IVUS, NIRS-IVUS, and OCT in a blind fashion.
The INVICTUS registry will provide new insights into the diagnostic value of CCTA for determining coronary atherosclerosis phenotype and coronary artery dimensions compared to IVUS, NIRS-IVUS, and OCT. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity. (ClinicalTrials.gov: NCT04066062).
The INVICTUS registry is a multicenter, retrospective, and prospective study designed to evaluate the dimensions of coronary arteries, as well as the characteristic, volume, and phenotype of coronary atherosclerosis by CCTA, compared with the invasive imaging modalities including intravascular ultrasound (IVUS), near-infrared spectroscopy-IVUS and optical coherence tomography. The main objective of the INVICTUS registry is to achieve a high diagnostic performance of CCTA and a more in-depth evaluation of the phenotype of coronary atherosclerosis. Our findings will potentially shed new light on precision medicine informed by an AI-based coronary CTA assessment of coronary atherosclerosis burden, composition, and severity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37679247</pmid><doi>10.1016/j.jcct.2023.08.011</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3558-4347</orcidid><orcidid>https://orcid.org/0000-0002-4237-3927</orcidid><orcidid>https://orcid.org/0000-0003-0657-514X</orcidid><orcidid>https://orcid.org/0000-0002-5433-2428</orcidid><orcidid>https://orcid.org/0000-0001-5748-7700</orcidid><orcidid>https://orcid.org/0000-0003-3097-7202</orcidid><orcidid>https://orcid.org/0000-0003-3258-2458</orcidid><orcidid>https://orcid.org/0000-0003-0334-9745</orcidid><orcidid>https://orcid.org/0000-0001-6367-8140</orcidid><orcidid>https://orcid.org/0000-0003-1418-1650</orcidid><orcidid>https://orcid.org/0000-0003-2057-109X</orcidid><orcidid>https://orcid.org/0000-0002-9039-3439</orcidid><orcidid>https://orcid.org/0000-0002-1950-7616</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1934-5925 |
| ispartof | Journal of cardiovascular computed tomography, 2023-11, Vol.17 (6), p.401-406 |
| issn | 1934-5925 1876-861X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2863301592 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Artificial Intelligence Calcified plaque Computed Tomography Angiography Coronary Angiography - methods Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary atherosclerosis Coronary computed tomography angiography Coronary Vessels - diagnostic imaging Humans Intravascular ultrasound Low density non-calcified plaque Near infrared spectroscopy intravascular ultrasound Non-calcified plaque Optical coherence tomography Plaque, Atherosclerotic Predictive Value of Tests Prospective Studies Retrospective Studies Tomography, Optical Coherence Ultrasonography, Interventional - methods |
| title | Rationale and design of the INVICTUS Registry: (Multicenter Registry of Invasive and Non-Invasive imaging modalities to compare Coronary Computed Tomography Angiography, Intravascular Ultrasound and Optical Coherence Tomography for the determination of Severity, Volume and Type of coronary atherosclerosiS) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T00%3A52%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rationale%20and%20design%20of%20the%20INVICTUS%20Registry:%20(Multicenter%20Registry%20of%20Invasive%20and%20Non-Invasive%20imaging%20modalities%20to%20compare%20Coronary%20Computed%20Tomography%20Angiography,%20Intravascular%20Ultrasound%20and%20Optical%20Coherence%20Tomography%20for%20the%20determination%20of%20Severity,%20Volume%20and%20Type%20of%20coronary%20atherosclerosiS)&rft.jtitle=Journal%20of%20cardiovascular%20computed%20tomography&rft.au=Nakanishi,%20Rine&rft.date=2023-11&rft.volume=17&rft.issue=6&rft.spage=401&rft.epage=406&rft.pages=401-406&rft.issn=1934-5925&rft.eissn=1876-861X&rft_id=info:doi/10.1016/j.jcct.2023.08.011&rft_dat=%3Cproquest_cross%3E2863301592%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2863301592&rft_id=info:pmid/37679247&rft_els_id=S1934592523004276&rfr_iscdi=true |