Design and synthesis of multivalent drug delivery system with CA IX inhibitors as ligands

[Display omitted] •We have developed a novel multivalent ligand delivery system for SN38, with a carbonic anhydrase IX (CA IX) inhibitor as the target ligand.•Our multivalent ligand delivery systems exhibited superior metabolic stability and enhanced targeting specificity compared to SMDC molecules....

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2023-10, Vol.93, p.117456-117456, Article 117456
Hauptverfasser:	Ding, Mengyuan, Zhu, Qiwen, Lu, Wei, Zhu, Shulei
Format:	Artikel
Sprache:	eng
Schlagworte:	CA IX Hypoxic Metabolic stability Multivalent ligand Targeting specificity
Online-Zugang:	Volltext
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