Transplacental transfer of cobalt: Evidence from a study of mothers and their neonates in the African Copperbelt
Transfer of the trace metal cobalt (Co) from mother to foetus has not been documented in populations with high environmental exposure to Co, as is the case in the African Copperbelt mining region. We analysed data obtained from 246 mother-infant pairs included (at delivery) in a previously published...
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| Veröffentlicht in: | Journal of trace elements in medicine and biology 2023-12, Vol.80, p.127294-127294, Article 127294 |
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| creator | Kayembe-Kitenge, Tony Nkulu, Célestin Banza Lubaba Musanzayi, Sébastien Mbuyi Kasole, Toni Lubala Ngombe, Leon Kabamba Obadia, Paul Musa Van Brusselen, Daan Mukoma, Daniel Kyanika Wa Musambo, Taty Muta Mulangu, Augustin Mutombo Banza, Patient Nkulu Katoto, P.D.M.C. Smolders, Erik Nemery, Benoit Nawrot, Tim |
| description | Transfer of the trace metal cobalt (Co) from mother to foetus has not been documented in populations with high environmental exposure to Co, as is the case in the African Copperbelt mining region. We analysed data obtained from 246 mother-infant pairs included (at delivery) in a previously published case-control study on birth defects, done in Lubumbashi (Democratic Republic of Congo) between March 1, 2013, and Feb 28, 2015. Methods: Co was measured by Inductively Coupled Plasma Mass Spectrometry in maternal blood, maternal urine, umbilical cord blood and placental tissue, as available.
The Co concentrations [geometric mean (GM) with interquartile range (IQR)] in maternal blood (GM 1.77 µg/L, IQR 1.07–2.93) and urine (GM 7.42 µg/g creatinine, IQR 4.41–11.0) were highly correlated (Spearman r = 0.71, n = 166; p |
| doi_str_mv | 10.1016/j.jtemb.2023.127294 |
| format | Article |
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The Co concentrations [geometric mean (GM) with interquartile range (IQR)] in maternal blood (GM 1.77 µg/L, IQR 1.07–2.93) and urine (GM 7.42 µg/g creatinine, IQR 4.41–11.0) were highly correlated (Spearman r = 0.71, n = 166; p < 0.001) and considerably higher than reference values determined for general populations elsewhere in the world. The concentrations of Co in umbilical cord blood (GM 2.41 µg/L) were higher (Wilcoxon test, p < 0.001) than in maternal blood (GM 1.37 µg/L), with a correlation between both values (Spearman r = 0.34; n = 127, p < 0.001). Co concentrations in placental tissue (geometric mean 0.02 µg/g wet weight) correlated with concentrations in maternal blood (Spearman r = 0.50, n = 86, p < 0.001) and in neonatal blood (Spearman r = 0.23, n = 83, p = 0.039).
This first study of maternal and neonatal Co concentrations in the African Copperbelt provides strong evidence of a high transfer of Co from mother to foetus.</description><identifier>ISSN: 0946-672X</identifier><identifier>EISSN: 1878-3252</identifier><identifier>DOI: 10.1016/j.jtemb.2023.127294</identifier><language>eng</language><publisher>Elsevier GmbH</publisher><subject>Katanga ; Metal-mining ; Mother-child ; Pregnancy, Global health</subject><ispartof>Journal of trace elements in medicine and biology, 2023-12, Vol.80, p.127294-127294, Article 127294</ispartof><rights>2023 Elsevier GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-1d24df3803d9a9e62785ee6814e888ab6c12a4c5dd3b306ddbb9dab129b12cf33</citedby><cites>FETCH-LOGICAL-c336t-1d24df3803d9a9e62785ee6814e888ab6c12a4c5dd3b306ddbb9dab129b12cf33</cites><orcidid>0000-0003-0571-4689 ; 0000-0001-8059-6665 ; 0000-0003-3054-2444</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0946672X23001700$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids></links><search><creatorcontrib>Kayembe-Kitenge, Tony</creatorcontrib><creatorcontrib>Nkulu, Célestin Banza Lubaba</creatorcontrib><creatorcontrib>Musanzayi, Sébastien Mbuyi</creatorcontrib><creatorcontrib>Kasole, Toni Lubala</creatorcontrib><creatorcontrib>Ngombe, Leon Kabamba</creatorcontrib><creatorcontrib>Obadia, Paul Musa</creatorcontrib><creatorcontrib>Van Brusselen, Daan</creatorcontrib><creatorcontrib>Mukoma, Daniel Kyanika Wa</creatorcontrib><creatorcontrib>Musambo, Taty Muta</creatorcontrib><creatorcontrib>Mulangu, Augustin Mutombo</creatorcontrib><creatorcontrib>Banza, Patient Nkulu</creatorcontrib><creatorcontrib>Katoto, P.D.M.C.</creatorcontrib><creatorcontrib>Smolders, Erik</creatorcontrib><creatorcontrib>Nemery, Benoit</creatorcontrib><creatorcontrib>Nawrot, Tim</creatorcontrib><title>Transplacental transfer of cobalt: Evidence from a study of mothers and their neonates in the African Copperbelt</title><title>Journal of trace elements in medicine and biology</title><description>Transfer of the trace metal cobalt (Co) from mother to foetus has not been documented in populations with high environmental exposure to Co, as is the case in the African Copperbelt mining region. We analysed data obtained from 246 mother-infant pairs included (at delivery) in a previously published case-control study on birth defects, done in Lubumbashi (Democratic Republic of Congo) between March 1, 2013, and Feb 28, 2015. Methods: Co was measured by Inductively Coupled Plasma Mass Spectrometry in maternal blood, maternal urine, umbilical cord blood and placental tissue, as available.
The Co concentrations [geometric mean (GM) with interquartile range (IQR)] in maternal blood (GM 1.77 µg/L, IQR 1.07–2.93) and urine (GM 7.42 µg/g creatinine, IQR 4.41–11.0) were highly correlated (Spearman r = 0.71, n = 166; p < 0.001) and considerably higher than reference values determined for general populations elsewhere in the world. The concentrations of Co in umbilical cord blood (GM 2.41 µg/L) were higher (Wilcoxon test, p < 0.001) than in maternal blood (GM 1.37 µg/L), with a correlation between both values (Spearman r = 0.34; n = 127, p < 0.001). Co concentrations in placental tissue (geometric mean 0.02 µg/g wet weight) correlated with concentrations in maternal blood (Spearman r = 0.50, n = 86, p < 0.001) and in neonatal blood (Spearman r = 0.23, n = 83, p = 0.039).
This first study of maternal and neonatal Co concentrations in the African Copperbelt provides strong evidence of a high transfer of Co from mother to foetus.</description><subject>Katanga</subject><subject>Metal-mining</subject><subject>Mother-child</subject><subject>Pregnancy, Global health</subject><issn>0946-672X</issn><issn>1878-3252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouK7-Ai85eumaj26aCh6WxS9Y8LKCt5AmU0xpm5pkF_bf21rPHob54H2HmQehW0pWlFBx36yaBF21YoTxFWUFK_MztKCykBlna3aOFqTMRSYK9nmJrmJsCKHFWrIFGvZB93FotYE-6Ranqa0hYF9j4yvdpgf8dHQWegO4Dr7DGsd0sKdJ0Pn0BSFi3Vs8Vi7gHnyvE0Ts-mmCN3VwRvd464cBQgVtukYXtW4j3PzlJfp4ftpvX7Pd-8vbdrPLDOciZdSy3NZcEm5LXYJghVwDCElzkFLqShjKdG7W1vKKE2FtVZVWV5SVY5ia8yW6m_cOwX8fICbVuWigbfV44yEqJgVnZUk4HaV8lprgYwxQqyG4ToeTokRNfFWjfvmqia-a-Y6ux9kF4xdHB0FF4yZM1gUwSVnv_vX_APiuhoc</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Kayembe-Kitenge, Tony</creator><creator>Nkulu, Célestin Banza Lubaba</creator><creator>Musanzayi, Sébastien Mbuyi</creator><creator>Kasole, Toni Lubala</creator><creator>Ngombe, Leon Kabamba</creator><creator>Obadia, Paul Musa</creator><creator>Van Brusselen, Daan</creator><creator>Mukoma, Daniel Kyanika Wa</creator><creator>Musambo, Taty Muta</creator><creator>Mulangu, Augustin Mutombo</creator><creator>Banza, Patient Nkulu</creator><creator>Katoto, P.D.M.C.</creator><creator>Smolders, Erik</creator><creator>Nemery, Benoit</creator><creator>Nawrot, Tim</creator><general>Elsevier GmbH</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0571-4689</orcidid><orcidid>https://orcid.org/0000-0001-8059-6665</orcidid><orcidid>https://orcid.org/0000-0003-3054-2444</orcidid></search><sort><creationdate>202312</creationdate><title>Transplacental transfer of cobalt: Evidence from a study of mothers and their neonates in the African Copperbelt</title><author>Kayembe-Kitenge, Tony ; Nkulu, Célestin Banza Lubaba ; Musanzayi, Sébastien Mbuyi ; Kasole, Toni Lubala ; Ngombe, Leon Kabamba ; Obadia, Paul Musa ; Van Brusselen, Daan ; Mukoma, Daniel Kyanika Wa ; Musambo, Taty Muta ; Mulangu, Augustin Mutombo ; Banza, Patient Nkulu ; Katoto, P.D.M.C. ; Smolders, Erik ; Nemery, Benoit ; Nawrot, Tim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-1d24df3803d9a9e62785ee6814e888ab6c12a4c5dd3b306ddbb9dab129b12cf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Katanga</topic><topic>Metal-mining</topic><topic>Mother-child</topic><topic>Pregnancy, Global health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kayembe-Kitenge, Tony</creatorcontrib><creatorcontrib>Nkulu, Célestin Banza Lubaba</creatorcontrib><creatorcontrib>Musanzayi, Sébastien Mbuyi</creatorcontrib><creatorcontrib>Kasole, Toni Lubala</creatorcontrib><creatorcontrib>Ngombe, Leon Kabamba</creatorcontrib><creatorcontrib>Obadia, Paul Musa</creatorcontrib><creatorcontrib>Van Brusselen, Daan</creatorcontrib><creatorcontrib>Mukoma, Daniel Kyanika Wa</creatorcontrib><creatorcontrib>Musambo, Taty Muta</creatorcontrib><creatorcontrib>Mulangu, Augustin Mutombo</creatorcontrib><creatorcontrib>Banza, Patient Nkulu</creatorcontrib><creatorcontrib>Katoto, P.D.M.C.</creatorcontrib><creatorcontrib>Smolders, Erik</creatorcontrib><creatorcontrib>Nemery, Benoit</creatorcontrib><creatorcontrib>Nawrot, Tim</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of trace elements in medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kayembe-Kitenge, Tony</au><au>Nkulu, Célestin Banza Lubaba</au><au>Musanzayi, Sébastien Mbuyi</au><au>Kasole, Toni Lubala</au><au>Ngombe, Leon Kabamba</au><au>Obadia, Paul Musa</au><au>Van Brusselen, Daan</au><au>Mukoma, Daniel Kyanika Wa</au><au>Musambo, Taty Muta</au><au>Mulangu, Augustin Mutombo</au><au>Banza, Patient Nkulu</au><au>Katoto, P.D.M.C.</au><au>Smolders, Erik</au><au>Nemery, Benoit</au><au>Nawrot, Tim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplacental transfer of cobalt: Evidence from a study of mothers and their neonates in the African Copperbelt</atitle><jtitle>Journal of trace elements in medicine and biology</jtitle><date>2023-12</date><risdate>2023</risdate><volume>80</volume><spage>127294</spage><epage>127294</epage><pages>127294-127294</pages><artnum>127294</artnum><issn>0946-672X</issn><eissn>1878-3252</eissn><abstract>Transfer of the trace metal cobalt (Co) from mother to foetus has not been documented in populations with high environmental exposure to Co, as is the case in the African Copperbelt mining region. We analysed data obtained from 246 mother-infant pairs included (at delivery) in a previously published case-control study on birth defects, done in Lubumbashi (Democratic Republic of Congo) between March 1, 2013, and Feb 28, 2015. Methods: Co was measured by Inductively Coupled Plasma Mass Spectrometry in maternal blood, maternal urine, umbilical cord blood and placental tissue, as available.
The Co concentrations [geometric mean (GM) with interquartile range (IQR)] in maternal blood (GM 1.77 µg/L, IQR 1.07–2.93) and urine (GM 7.42 µg/g creatinine, IQR 4.41–11.0) were highly correlated (Spearman r = 0.71, n = 166; p < 0.001) and considerably higher than reference values determined for general populations elsewhere in the world. The concentrations of Co in umbilical cord blood (GM 2.41 µg/L) were higher (Wilcoxon test, p < 0.001) than in maternal blood (GM 1.37 µg/L), with a correlation between both values (Spearman r = 0.34; n = 127, p < 0.001). Co concentrations in placental tissue (geometric mean 0.02 µg/g wet weight) correlated with concentrations in maternal blood (Spearman r = 0.50, n = 86, p < 0.001) and in neonatal blood (Spearman r = 0.23, n = 83, p = 0.039).
This first study of maternal and neonatal Co concentrations in the African Copperbelt provides strong evidence of a high transfer of Co from mother to foetus.</abstract><pub>Elsevier GmbH</pub><doi>10.1016/j.jtemb.2023.127294</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0571-4689</orcidid><orcidid>https://orcid.org/0000-0001-8059-6665</orcidid><orcidid>https://orcid.org/0000-0003-3054-2444</orcidid></addata></record> |
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| subjects | Katanga Metal-mining Mother-child Pregnancy, Global health |
| title | Transplacental transfer of cobalt: Evidence from a study of mothers and their neonates in the African Copperbelt |
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