The ability of computed tomography angiography to predict 5-year mortality in the SYNTAX III REVOLUTION trial
The feasibility of using coronary computed tomography angiography (CCTA) for long-term prediction of vital prognosis post-revascularization remains unknown. To compare the prognostic value of the SYNTAX score II 2020 (SS-2020) derived from invasive coronary angiography (ICA) or CCTA in patients with...
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| Veröffentlicht in: | Journal of cardiovascular computed tomography 2023-09, Vol.17 (5), p.318-325 |
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| creator | Masuda, Shinichiro Serruys, Patrick W. Mushtaq, Saima Tanaka, Kaoru Mandry, Damien Buechel, Ronny R. Digne, Franck Schneider, Ulrich Pompilio, Giulio La Meir, Mark Doenst, Torsten Teichgraber, Ulf Morel, Marie-Angele Kotoku, Nozomi Ninomiya, Kai Kageyama, Shigetaka O’Leary, Neil Collet, Carlos Garg, Scot de Mey, Johan Andreini, Daniele Onuma, Yoshinobu |
| description | The feasibility of using coronary computed tomography angiography (CCTA) for long-term prediction of vital prognosis post-revascularization remains unknown.
To compare the prognostic value of the SYNTAX score II 2020 (SS-2020) derived from invasive coronary angiography (ICA) or CCTA in patients with three-vessel disease and/or left main coronary artery disease undergoing percutaneous or surgical revascularization.
In the SYNTAX III REVOLUTION trial, the probability of death at five years was retrospectively assessed by calculating the SS-2020 using ICA and CCTA. High- and low-risk patients for mortality were categorized according to the median percentages of predicted mortality based on both modalities. The discriminative abilities of the SS-2020 were assessed using Harrell's C statistic.
The vital status at five years of the 215 patients revascularized percutaneously (64 patients, 29.8%) or surgically (151 patients, 70.2%) was established through national registries. In patients undergoing revascularization, the SS-2020 was possibly helpful in discriminating vital prognosis at 5 years, with similar results seen with ICA and CCTA (C-index with ICA = 0.75, intercept = −0.19, slope = 0.92 and C-index with CCTA = 0.75, intercept = −0.22, slope = 0.99). In high- and low-risk patients, Kaplan-Meier estimates showed significant, and almost identical relative differences in observed mortality, irrespective of imaging modality (ICA: 93.8% vs 78.7%, log-lank P |
| doi_str_mv | 10.1016/j.jcct.2023.08.006 |
| format | Article |
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To compare the prognostic value of the SYNTAX score II 2020 (SS-2020) derived from invasive coronary angiography (ICA) or CCTA in patients with three-vessel disease and/or left main coronary artery disease undergoing percutaneous or surgical revascularization.
In the SYNTAX III REVOLUTION trial, the probability of death at five years was retrospectively assessed by calculating the SS-2020 using ICA and CCTA. High- and low-risk patients for mortality were categorized according to the median percentages of predicted mortality based on both modalities. The discriminative abilities of the SS-2020 were assessed using Harrell's C statistic.
The vital status at five years of the 215 patients revascularized percutaneously (64 patients, 29.8%) or surgically (151 patients, 70.2%) was established through national registries. In patients undergoing revascularization, the SS-2020 was possibly helpful in discriminating vital prognosis at 5 years, with similar results seen with ICA and CCTA (C-index with ICA = 0.75, intercept = −0.19, slope = 0.92 and C-index with CCTA = 0.75, intercept = −0.22, slope = 0.99). In high- and low-risk patients, Kaplan-Meier estimates showed significant, and almost identical relative differences in observed mortality, irrespective of imaging modality (ICA: 93.8% vs 78.7%, log-lank P < 0.001; CCTA: 93.7% vs 78.5%, log-lank P < 0.001).
The predictive ability of the SS-2020 for five-year all-cause mortality derived from ICA and CCTA was comparable, and could helpfully discriminate vital prognosis in high- and low-risk patients.</description><identifier>ISSN: 1934-5925</identifier><identifier>EISSN: 1876-861X</identifier><identifier>DOI: 10.1016/j.jcct.2023.08.006</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Coronary computed tomography angiography ; Invasive coronary artery ; Predictive ability ; SYNTAX score 2020</subject><ispartof>Journal of cardiovascular computed tomography, 2023-09, Vol.17 (5), p.318-325</ispartof><rights>2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-3c0492636d191a80c8dccab2fe1d8012bd9668af6140e98db08f53b71f53d863</citedby><cites>FETCH-LOGICAL-c333t-3c0492636d191a80c8dccab2fe1d8012bd9668af6140e98db08f53b71f53d863</cites><orcidid>0000-0002-4048-3938 ; 0000-0001-7702-0649 ; 0000-0003-2127-7538 ; 0000-0002-9636-1104 ; 0000-0002-8911-0278 ; 0000-0001-8064-8904 ; 0000-0001-5533-3185 ; 0000-0003-4982-3203</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids></links><search><creatorcontrib>Masuda, Shinichiro</creatorcontrib><creatorcontrib>Serruys, Patrick W.</creatorcontrib><creatorcontrib>Mushtaq, Saima</creatorcontrib><creatorcontrib>Tanaka, Kaoru</creatorcontrib><creatorcontrib>Mandry, Damien</creatorcontrib><creatorcontrib>Buechel, Ronny R.</creatorcontrib><creatorcontrib>Digne, Franck</creatorcontrib><creatorcontrib>Schneider, Ulrich</creatorcontrib><creatorcontrib>Pompilio, Giulio</creatorcontrib><creatorcontrib>La Meir, Mark</creatorcontrib><creatorcontrib>Doenst, Torsten</creatorcontrib><creatorcontrib>Teichgraber, Ulf</creatorcontrib><creatorcontrib>Morel, Marie-Angele</creatorcontrib><creatorcontrib>Kotoku, Nozomi</creatorcontrib><creatorcontrib>Ninomiya, Kai</creatorcontrib><creatorcontrib>Kageyama, Shigetaka</creatorcontrib><creatorcontrib>O’Leary, Neil</creatorcontrib><creatorcontrib>Collet, Carlos</creatorcontrib><creatorcontrib>Garg, Scot</creatorcontrib><creatorcontrib>de Mey, Johan</creatorcontrib><creatorcontrib>Andreini, Daniele</creatorcontrib><creatorcontrib>Onuma, Yoshinobu</creatorcontrib><title>The ability of computed tomography angiography to predict 5-year mortality in the SYNTAX III REVOLUTION trial</title><title>Journal of cardiovascular computed tomography</title><description>The feasibility of using coronary computed tomography angiography (CCTA) for long-term prediction of vital prognosis post-revascularization remains unknown.
To compare the prognostic value of the SYNTAX score II 2020 (SS-2020) derived from invasive coronary angiography (ICA) or CCTA in patients with three-vessel disease and/or left main coronary artery disease undergoing percutaneous or surgical revascularization.
In the SYNTAX III REVOLUTION trial, the probability of death at five years was retrospectively assessed by calculating the SS-2020 using ICA and CCTA. High- and low-risk patients for mortality were categorized according to the median percentages of predicted mortality based on both modalities. The discriminative abilities of the SS-2020 were assessed using Harrell's C statistic.
The vital status at five years of the 215 patients revascularized percutaneously (64 patients, 29.8%) or surgically (151 patients, 70.2%) was established through national registries. In patients undergoing revascularization, the SS-2020 was possibly helpful in discriminating vital prognosis at 5 years, with similar results seen with ICA and CCTA (C-index with ICA = 0.75, intercept = −0.19, slope = 0.92 and C-index with CCTA = 0.75, intercept = −0.22, slope = 0.99). In high- and low-risk patients, Kaplan-Meier estimates showed significant, and almost identical relative differences in observed mortality, irrespective of imaging modality (ICA: 93.8% vs 78.7%, log-lank P < 0.001; CCTA: 93.7% vs 78.5%, log-lank P < 0.001).
The predictive ability of the SS-2020 for five-year all-cause mortality derived from ICA and CCTA was comparable, and could helpfully discriminate vital prognosis in high- and low-risk patients.</description><subject>Coronary computed tomography angiography</subject><subject>Invasive coronary artery</subject><subject>Predictive ability</subject><subject>SYNTAX score 2020</subject><issn>1934-5925</issn><issn>1876-861X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LwzAYh4soOKdfwFOOXlrzZ81S8DLG1MLYQKvMU0iTdMtol5pkwr69mdOrl_d9D8_vB--TJLcIZggier_NtlKGDENMMsgyCOlZMkBsTFNG0eo83gUZpXmB88vkyvsthPkYQTZIumqjgahNa8IB2AZI2_X7oBUItrNrJ_rNAYjd2vzdwYLeaWVkAHl60MKBzrogfuJmB0Jse_1YVJMVKMsSvMzel_O3qlwuQHBGtNfJRSNar29-9zCpHmfV9DmdL5_K6WSeSkJISImEowJTQhUqkGBQMiWlqHGjkWIQ4VoVlDLRUDSCumCqhqzJST1GcSpGyTC5O9X2zn7utQ-8M17qthU7bfee48jgWJEfUXxCpbPeO93w3plOuANHkB_V8i0_quVHtRwyHtXG0MMppOMPX0Y77qXROxm9OB1ZZc1_8W_JjIHz</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Masuda, Shinichiro</creator><creator>Serruys, Patrick W.</creator><creator>Mushtaq, Saima</creator><creator>Tanaka, Kaoru</creator><creator>Mandry, Damien</creator><creator>Buechel, Ronny R.</creator><creator>Digne, Franck</creator><creator>Schneider, Ulrich</creator><creator>Pompilio, Giulio</creator><creator>La Meir, Mark</creator><creator>Doenst, Torsten</creator><creator>Teichgraber, Ulf</creator><creator>Morel, Marie-Angele</creator><creator>Kotoku, Nozomi</creator><creator>Ninomiya, Kai</creator><creator>Kageyama, Shigetaka</creator><creator>O’Leary, Neil</creator><creator>Collet, Carlos</creator><creator>Garg, Scot</creator><creator>de Mey, Johan</creator><creator>Andreini, Daniele</creator><creator>Onuma, Yoshinobu</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4048-3938</orcidid><orcidid>https://orcid.org/0000-0001-7702-0649</orcidid><orcidid>https://orcid.org/0000-0003-2127-7538</orcidid><orcidid>https://orcid.org/0000-0002-9636-1104</orcidid><orcidid>https://orcid.org/0000-0002-8911-0278</orcidid><orcidid>https://orcid.org/0000-0001-8064-8904</orcidid><orcidid>https://orcid.org/0000-0001-5533-3185</orcidid><orcidid>https://orcid.org/0000-0003-4982-3203</orcidid></search><sort><creationdate>202309</creationdate><title>The ability of computed tomography angiography to predict 5-year mortality in the SYNTAX III REVOLUTION trial</title><author>Masuda, Shinichiro ; 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To compare the prognostic value of the SYNTAX score II 2020 (SS-2020) derived from invasive coronary angiography (ICA) or CCTA in patients with three-vessel disease and/or left main coronary artery disease undergoing percutaneous or surgical revascularization.
In the SYNTAX III REVOLUTION trial, the probability of death at five years was retrospectively assessed by calculating the SS-2020 using ICA and CCTA. High- and low-risk patients for mortality were categorized according to the median percentages of predicted mortality based on both modalities. The discriminative abilities of the SS-2020 were assessed using Harrell's C statistic.
The vital status at five years of the 215 patients revascularized percutaneously (64 patients, 29.8%) or surgically (151 patients, 70.2%) was established through national registries. In patients undergoing revascularization, the SS-2020 was possibly helpful in discriminating vital prognosis at 5 years, with similar results seen with ICA and CCTA (C-index with ICA = 0.75, intercept = −0.19, slope = 0.92 and C-index with CCTA = 0.75, intercept = −0.22, slope = 0.99). In high- and low-risk patients, Kaplan-Meier estimates showed significant, and almost identical relative differences in observed mortality, irrespective of imaging modality (ICA: 93.8% vs 78.7%, log-lank P < 0.001; CCTA: 93.7% vs 78.5%, log-lank P < 0.001).
The predictive ability of the SS-2020 for five-year all-cause mortality derived from ICA and CCTA was comparable, and could helpfully discriminate vital prognosis in high- and low-risk patients.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.jcct.2023.08.006</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4048-3938</orcidid><orcidid>https://orcid.org/0000-0001-7702-0649</orcidid><orcidid>https://orcid.org/0000-0003-2127-7538</orcidid><orcidid>https://orcid.org/0000-0002-9636-1104</orcidid><orcidid>https://orcid.org/0000-0002-8911-0278</orcidid><orcidid>https://orcid.org/0000-0001-8064-8904</orcidid><orcidid>https://orcid.org/0000-0001-5533-3185</orcidid><orcidid>https://orcid.org/0000-0003-4982-3203</orcidid></addata></record> |
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| subjects | Coronary computed tomography angiography Invasive coronary artery Predictive ability SYNTAX score 2020 |
| title | The ability of computed tomography angiography to predict 5-year mortality in the SYNTAX III REVOLUTION trial |
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