Pharmacokinetic–pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells

The study aimed to explore the pharmacokinetic and pharmacodynamic alterations of the active components of Shenkang injection (i.e. hydroxy saffron yellow pigment A [HSYA], tanshinol, rheum emodin, and astragaloside IV) in rats with chronic renal failure (CRF), and establish a pharmacokinetic–pharma...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2023-12, Vol.44 (6), p.406-419
Hauptverfasser:	Zhou, Lin, Wang, Xiaohui, Xia, Jinlan, Zhang, Liyuan, Xue, Lianping, Jia, Qingquan, Fu, Zhihui, Sun, Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Connective tissue growth factor Connective tissues Creatinine Emodin Fibrosis Injection Kidneys Pharmacodynamics Pharmacokinetics Renal failure Serum levels Statistical analysis Statistics Traditional Chinese medicine Uric acid
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