Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea
Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like Foeniculum vulgare and Peumus boldus and is used to treat GIT disorders. Research reports have indicated its strong anti-inflammatory, antioxidant, and anti-nociceptive properties. The present study was designed...
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| Veröffentlicht in: | Inflammopharmacology 2023-10, Vol.31 (5), p.2479-2491 |
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| creator | Nawaz, Shoaib Irfan, Hafiz Muhammad Alamgeer Arshad, Laiba Jahan, Shah |
| description | Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like
Foeniculum vulgare
and
Peumus boldus
and is used to treat GIT disorders. Research reports have indicated its strong anti-inflammatory, antioxidant, and anti-nociceptive properties. The present study was designed to investigate fenchone’s anti-arthritic effects in a rat model of chronic joint inflammation (Complete Freud’s Adjuvant-mediated inflammation [CFA]). Molecular docking analysis revealed a high binding interaction of fenchone with inducible nitric oxide synthase (iNOS), Interleukin-17, Prostaglandin E Receptor EP4, and Cycloxygenase-2 (COX-2), indicating its anti-inflammatory efficacy using computational tests. Fenchone treatment at 100 mg/kg, 200 mg/kg, and 400 mg/kg significantly enhanced the tail-flick latency when compared with the solvent-treated group. Correspondingly, the raised mRNA values of iNOS, IL-17, IL-1β, IL-6, TNF-α, and COX-2 in solvent-treated group were significantly reduced following treatment with fenchone. Moreover, fenchone significantly lowered spleen and thymus indices, Nitric oxide (NO) and PGE2 values as compared to solvent-treated group. Hence, the results of the present study indicated that fenchone has a potent anti-inflammatory effect by inhibiting pro-inflammatory markers and thus may have therapeutic potential for chronic joint inflammation as well as chronic inflammatory disorders. |
| doi_str_mv | 10.1007/s10787-023-01333-7 |
| format | Article |
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Foeniculum vulgare
and
Peumus boldus
and is used to treat GIT disorders. Research reports have indicated its strong anti-inflammatory, antioxidant, and anti-nociceptive properties. The present study was designed to investigate fenchone’s anti-arthritic effects in a rat model of chronic joint inflammation (Complete Freud’s Adjuvant-mediated inflammation [CFA]). Molecular docking analysis revealed a high binding interaction of fenchone with inducible nitric oxide synthase (iNOS), Interleukin-17, Prostaglandin E Receptor EP4, and Cycloxygenase-2 (COX-2), indicating its anti-inflammatory efficacy using computational tests. Fenchone treatment at 100 mg/kg, 200 mg/kg, and 400 mg/kg significantly enhanced the tail-flick latency when compared with the solvent-treated group. Correspondingly, the raised mRNA values of iNOS, IL-17, IL-1β, IL-6, TNF-α, and COX-2 in solvent-treated group were significantly reduced following treatment with fenchone. Moreover, fenchone significantly lowered spleen and thymus indices, Nitric oxide (NO) and PGE2 values as compared to solvent-treated group. Hence, the results of the present study indicated that fenchone has a potent anti-inflammatory effect by inhibiting pro-inflammatory markers and thus may have therapeutic potential for chronic joint inflammation as well as chronic inflammatory disorders.</description><identifier>ISSN: 0925-4692</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-023-01333-7</identifier><identifier>PMID: 37689616</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Animals ; Arthritis ; Biomedical and Life Sciences ; Biomedicine ; C-Reactive Protein ; Camphanes ; Cyclooxygenase 2 ; Dermatology ; Freund's Adjuvant ; Gastroenterology ; Immunology ; Inflammation - drug therapy ; Molecular Docking Simulation ; Monoterpenes - pharmacology ; Nitric Oxide ; Original Article ; Pharmacology/Toxicology ; Prostaglandins ; Rats ; Rheumatology ; Urea</subject><ispartof>Inflammopharmacology, 2023-10, Vol.31 (5), p.2479-2491</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-5c558b1ba1f51c1f89dcbc6a681dc050dbdcce284ab90e9b332d245ad38bae683</citedby><cites>FETCH-LOGICAL-c347t-5c558b1ba1f51c1f89dcbc6a681dc050dbdcce284ab90e9b332d245ad38bae683</cites><orcidid>0000-0003-0572-2072</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10787-023-01333-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10787-023-01333-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37689616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nawaz, Shoaib</creatorcontrib><creatorcontrib>Irfan, Hafiz Muhammad</creatorcontrib><creatorcontrib>Alamgeer</creatorcontrib><creatorcontrib>Arshad, Laiba</creatorcontrib><creatorcontrib>Jahan, Shah</creatorcontrib><title>Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description>Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like
Foeniculum vulgare
and
Peumus boldus
and is used to treat GIT disorders. Research reports have indicated its strong anti-inflammatory, antioxidant, and anti-nociceptive properties. The present study was designed to investigate fenchone’s anti-arthritic effects in a rat model of chronic joint inflammation (Complete Freud’s Adjuvant-mediated inflammation [CFA]). Molecular docking analysis revealed a high binding interaction of fenchone with inducible nitric oxide synthase (iNOS), Interleukin-17, Prostaglandin E Receptor EP4, and Cycloxygenase-2 (COX-2), indicating its anti-inflammatory efficacy using computational tests. Fenchone treatment at 100 mg/kg, 200 mg/kg, and 400 mg/kg significantly enhanced the tail-flick latency when compared with the solvent-treated group. Correspondingly, the raised mRNA values of iNOS, IL-17, IL-1β, IL-6, TNF-α, and COX-2 in solvent-treated group were significantly reduced following treatment with fenchone. Moreover, fenchone significantly lowered spleen and thymus indices, Nitric oxide (NO) and PGE2 values as compared to solvent-treated group. Hence, the results of the present study indicated that fenchone has a potent anti-inflammatory effect by inhibiting pro-inflammatory markers and thus may have therapeutic potential for chronic joint inflammation as well as chronic inflammatory disorders.</description><subject>Allergology</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>C-Reactive Protein</subject><subject>Camphanes</subject><subject>Cyclooxygenase 2</subject><subject>Dermatology</subject><subject>Freund's Adjuvant</subject><subject>Gastroenterology</subject><subject>Immunology</subject><subject>Inflammation - drug therapy</subject><subject>Molecular Docking Simulation</subject><subject>Monoterpenes - pharmacology</subject><subject>Nitric Oxide</subject><subject>Original Article</subject><subject>Pharmacology/Toxicology</subject><subject>Prostaglandins</subject><subject>Rats</subject><subject>Rheumatology</subject><subject>Urea</subject><issn>0925-4692</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIkPgB1ggL1nE4Ee3270cjRJAisQG1pYf1RNH3fZguxHzN3wqTjqwZFWluqeuqnQResvoB0bp8LEwOqiBUC4IZUIIMjxDO9ZLRXpJ1XO0oyPvSSdHfoFelXJPKZWDHF-iCzFINUomd-j3vlaIq6khRZwmfLjZkxD96sBjd5dTDA6HOM1mWTbGnrHBNrizm5u0pJgq5BNEwBNEd5daU00-Qg3xiB-dgp0Bx1Bz49Ov4OEKn3Iq1RxnE32I5QofSAbjavgJD1KFEHGT8Nqmr9GLycwF3jzVS_T95vrb4TO5_frpy2F_S5zohkp61_fKMmvY1DPHJjV6Z500UjHvaE-99c4BV52xI4XRCsE973rjhbIGpBKX6P3m2w74sUKpegnFwdxuhLQWzZUUfBS8Ew3lG-raGyXDpE85LCafNaP6IRm9JaNbMvoxGT20pXdP_qtdwP9b-RtFA8QGlCbFI2R9n9Yc28__s_0Dg02dzw</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Nawaz, Shoaib</creator><creator>Irfan, Hafiz Muhammad</creator><creator>Alamgeer</creator><creator>Arshad, Laiba</creator><creator>Jahan, Shah</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0572-2072</orcidid></search><sort><creationdate>20231001</creationdate><title>Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea</title><author>Nawaz, Shoaib ; Irfan, Hafiz Muhammad ; Alamgeer ; Arshad, Laiba ; Jahan, Shah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-5c558b1ba1f51c1f89dcbc6a681dc050dbdcce284ab90e9b332d245ad38bae683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>C-Reactive Protein</topic><topic>Camphanes</topic><topic>Cyclooxygenase 2</topic><topic>Dermatology</topic><topic>Freund's Adjuvant</topic><topic>Gastroenterology</topic><topic>Immunology</topic><topic>Inflammation - drug therapy</topic><topic>Molecular Docking Simulation</topic><topic>Monoterpenes - pharmacology</topic><topic>Nitric Oxide</topic><topic>Original Article</topic><topic>Pharmacology/Toxicology</topic><topic>Prostaglandins</topic><topic>Rats</topic><topic>Rheumatology</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nawaz, Shoaib</creatorcontrib><creatorcontrib>Irfan, Hafiz Muhammad</creatorcontrib><creatorcontrib>Alamgeer</creatorcontrib><creatorcontrib>Arshad, Laiba</creatorcontrib><creatorcontrib>Jahan, Shah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nawaz, Shoaib</au><au>Irfan, Hafiz Muhammad</au><au>Alamgeer</au><au>Arshad, Laiba</au><au>Jahan, Shah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea</atitle><jtitle>Inflammopharmacology</jtitle><stitle>Inflammopharmacol</stitle><addtitle>Inflammopharmacology</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>31</volume><issue>5</issue><spage>2479</spage><epage>2491</epage><pages>2479-2491</pages><issn>0925-4692</issn><eissn>1568-5608</eissn><abstract>Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like
Foeniculum vulgare
and
Peumus boldus
and is used to treat GIT disorders. Research reports have indicated its strong anti-inflammatory, antioxidant, and anti-nociceptive properties. The present study was designed to investigate fenchone’s anti-arthritic effects in a rat model of chronic joint inflammation (Complete Freud’s Adjuvant-mediated inflammation [CFA]). Molecular docking analysis revealed a high binding interaction of fenchone with inducible nitric oxide synthase (iNOS), Interleukin-17, Prostaglandin E Receptor EP4, and Cycloxygenase-2 (COX-2), indicating its anti-inflammatory efficacy using computational tests. Fenchone treatment at 100 mg/kg, 200 mg/kg, and 400 mg/kg significantly enhanced the tail-flick latency when compared with the solvent-treated group. Correspondingly, the raised mRNA values of iNOS, IL-17, IL-1β, IL-6, TNF-α, and COX-2 in solvent-treated group were significantly reduced following treatment with fenchone. Moreover, fenchone significantly lowered spleen and thymus indices, Nitric oxide (NO) and PGE2 values as compared to solvent-treated group. Hence, the results of the present study indicated that fenchone has a potent anti-inflammatory effect by inhibiting pro-inflammatory markers and thus may have therapeutic potential for chronic joint inflammation as well as chronic inflammatory disorders.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37689616</pmid><doi>10.1007/s10787-023-01333-7</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-0572-2072</orcidid></addata></record> |
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| subjects | Allergology Animals Arthritis Biomedical and Life Sciences Biomedicine C-Reactive Protein Camphanes Cyclooxygenase 2 Dermatology Freund's Adjuvant Gastroenterology Immunology Inflammation - drug therapy Molecular Docking Simulation Monoterpenes - pharmacology Nitric Oxide Original Article Pharmacology/Toxicology Prostaglandins Rats Rheumatology Urea |
| title | Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea |
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