Is Target-Based Drug Discovery Efficient? Discovery and “Off-Target” Mechanisms of All Drugs
Target-based drug discovery is the dominant paradigm of drug discovery; however, a comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic review of about 32000 articles and patents dating back to 150 years ago demonstrates its apparent inefficiency. Analyzing the...
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| Veröffentlicht in: | Journal of medicinal chemistry 2023-09, Vol.66 (18), p.12651-12677 |
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| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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