5-Fluorouracil and Anti-EGFR antibody scaffold chitosan-stabilized Pickering emulsion: Formulations, physical characterization, in-vitro studies in NCL-H226 cells, and in-vivo investigations in Wistar rats for the augmented therapeutic effects against squamous cell carcinoma

This research seeks to optimize a chitosan-stabilized Pickering emulsion (PE) containing 5-fluorouracil (5-FU) as a potential Squamous Cell Carcinoma therapy. The 5-Fluorouracil was also thoroughly analysed using UV spectrophotometry and RP-HPLC, demonstrating exceptional linearity, sensitivity, pre...

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Veröffentlicht in:	International journal of biological macromolecules 2023-12, Vol.253, p.126716-126716, Article 126716
Hauptverfasser:	Bhattacharya, Sankha, Shinde, Prafull, Page, Amit, Sharma, Satyam
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil antibodies apoptosis Chitosan DNA fragmentation emulsions encapsulation fluorouracil gels growth retardation inhibitory concentration 50 membrane potential mitochondrial membrane physical properties spectroscopy squamous cell carcinoma therapeutics
Online-Zugang:	Volltext
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