Alpha-1 antitrypsin protects against phosgene-induced acute lung injury by activating the ID1-dependent anti-inflammatory response

Phosgene is widely used as an industrial chemical, and phosgene inhalation causes acute lung injury (ALI), which may further progress into pulmonary edema. Currently, an antidote for phosgene poisoning is not known. Alpha-1 antitrypsin (α1-AT) is a protease inhibitor used to treat patients with emph...

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Veröffentlicht in:	European journal of pharmacology 2023-10, Vol.957, p.176017-176017, Article 176017
Hauptverfasser:	He, Gaihua, Yu, Weihua, Li, Hongwei, Liu, Jiangzheng, Tu, Yongmei, Kong, Deqin, Long, Zi, Liu, Rui, Peng, Jie, Wang, Zhao, Liu, Penghui, Hai, Chunxu, Yan, Wenjun, Li, Wenli
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury ID1 Inflammation Phosgene α1-AT
Online-Zugang:	Volltext
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