Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation

Pancreatic cancer is a highly aggressive form of cancer with a poor prognosis, partly due to 'austerity', a phenomenon of tolerance to nutrient deprivation and survival in its hypovascular tumor microenvironment. Anti-austerity agents which preferentially diminish the survival of cancer ce...

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Veröffentlicht in:	Chemistry & biodiversity 2023-09, Vol.20 (9), p.e202300280-e202300280
Hauptverfasser:	Fujihashi, Yuki, Jo Kim, Min, Maneenet, Juthamart, Awale, Suresh
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Agents, Phytogenic - pharmacology Autophagy Cancer Cell Death Cell Line, Tumor Cell migration Constituents Cytotoxicity Drug Screening Assays, Antitumor Humans Lead compounds Nutrients Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Piper Piper longum Pipernonaline Starvation Survival TOR protein Tumor Microenvironment
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