Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice

Regulatory T cells (T ) are protective in atherosclerosis but reduced during disease progression due to cell death and loss of stability. However, the mechanisms of T dysfunction remain unknown. Oxidized phospholipids are abundant in atherosclerosis and can activate innate immune cells, but little i...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2023-11, Vol.43 (11), p.2119-2132
Hauptverfasser:	Appleton, Brenna D, Palmer, Sydney A, Smith, Harrison P, Stephens, Lilly E, Major, Amy S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - genetics Atherosclerosis - prevention & control Cell Differentiation Interferon-gamma - metabolism Mice Phospholipids - metabolism T-Lymphocytes, Regulatory
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