Effects of inflammation, childhood adversity, and psychiatric symptoms on brain morphometrical phenotypes in bipolar II depression
The neuroanatomical alteration in bipolar II depression (BDII-D) and its associations with inflammation, childhood adversity, and psychiatric symptoms are currently unclear. We hypothesize that neuroanatomical deficits will be related to higher inflammation, greater childhood adversity, and worse ps...
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| Veröffentlicht in: | Psychological medicine 2024-03, Vol.54 (4), p.775-784 |
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| creator | Cao, Yuan Sun, Huan Lizano, Paulo Deng, Gaoju Zhou, Xiaoqin Xie, Hongsheng Mu, Jingshi Long, Xipeng Xiao, Hongqi Liu, Shiyu Wu, Baolin Gong, Qiyong Qiu, Changjian Jia, Zhiyun |
| description | The neuroanatomical alteration in bipolar II depression (BDII-D) and its associations with inflammation, childhood adversity, and psychiatric symptoms are currently unclear. We hypothesize that neuroanatomical deficits will be related to higher inflammation, greater childhood adversity, and worse psychiatric symptoms in BDII-D.
Voxel- and surface-based morphometry was performed using the CAT toolbox in 150 BDII-D patients and 155 healthy controls (HCs). Partial Pearson correlations followed by multiple comparison correction was used to indicate significant relationships between neuroanatomy and inflammation, childhood adversity, and psychiatric symptoms.
Compared with HCs, the BDII-D group demonstrated significantly smaller gray matter volumes (GMVs) in frontostriatal and fronto-cerebellar area, insula, rectus, and temporal gyrus, while significantly thinner cortices were found in frontal and temporal areas. In BDII-D, smaller GMV in the right middle frontal gyrus (MFG) was correlated with greater sexual abuse (
= -0.348,
< 0.001) while larger GMV in the right orbital MFG was correlated with greater physical neglect (
= 0.254,
= 0.03). Higher WBC count (
= -0.227,
= 0.015) and IL-6 levels (
= -0.266,
= 0.015) was associated with smaller GMVs in fronto-cerebellar area in BDII-D. Greater positive symptoms was correlated with larger GMVs of the left middle temporal pole (
= 0.245,
= 0.03).
Neuroanatomical alterations in frontostriatal and fronto-cerebellar area, insula, rectus, temporal gyrus volumes, and frontal-temporal thickness may reflect a core pathophysiological mechanism of BDII-D, which are related to inflammation, trauma, and psychiatric symptoms in BDII-D. |
| doi_str_mv | 10.1017/S0033291723002477 |
| format | Article |
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Voxel- and surface-based morphometry was performed using the CAT toolbox in 150 BDII-D patients and 155 healthy controls (HCs). Partial Pearson correlations followed by multiple comparison correction was used to indicate significant relationships between neuroanatomy and inflammation, childhood adversity, and psychiatric symptoms.
Compared with HCs, the BDII-D group demonstrated significantly smaller gray matter volumes (GMVs) in frontostriatal and fronto-cerebellar area, insula, rectus, and temporal gyrus, while significantly thinner cortices were found in frontal and temporal areas. In BDII-D, smaller GMV in the right middle frontal gyrus (MFG) was correlated with greater sexual abuse (
= -0.348,
< 0.001) while larger GMV in the right orbital MFG was correlated with greater physical neglect (
= 0.254,
= 0.03). Higher WBC count (
= -0.227,
= 0.015) and IL-6 levels (
= -0.266,
= 0.015) was associated with smaller GMVs in fronto-cerebellar area in BDII-D. Greater positive symptoms was correlated with larger GMVs of the left middle temporal pole (
= 0.245,
= 0.03).
Neuroanatomical alterations in frontostriatal and fronto-cerebellar area, insula, rectus, temporal gyrus volumes, and frontal-temporal thickness may reflect a core pathophysiological mechanism of BDII-D, which are related to inflammation, trauma, and psychiatric symptoms in BDII-D.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291723002477</identifier><identifier>PMID: 37671675</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Adverse Childhood Experiences ; Adversity ; Anatomy ; Bipolar disorder ; Bipolar Disorder - diagnostic imaging ; Blood ; Brain - diagnostic imaging ; Brain architecture ; Brain research ; Cerebellum ; Childhood ; Children ; Cytokines ; Depression - diagnostic imaging ; Frontal gyrus ; Gray Matter - diagnostic imaging ; Humans ; Inflammation ; Inflammation - diagnostic imaging ; Lymphocytes ; Magnetic Resonance Imaging ; Mental depression ; Morphometry ; Neuroanatomy ; Phenotypes ; Psychiatric symptoms ; Psychotropic drugs ; Sexual abuse ; Statistical analysis ; Substantia grisea ; Symptoms ; Temporal gyrus ; Time ; Trauma</subject><ispartof>Psychological medicine, 2024-03, Vol.54 (4), p.775-784</ispartof><rights>Copyright © The Author(s), 2023. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-f4c1653fd48be9513fc2dfa7ea7f36128339dace5ec489fe34ea0581c2a514203</citedby><cites>FETCH-LOGICAL-c329t-f4c1653fd48be9513fc2dfa7ea7f36128339dace5ec489fe34ea0581c2a514203</cites><orcidid>0000-0003-1886-5654 ; 0000-0002-1906-2530 ; 0000-0002-3105-7654</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,12825,27321,27901,27902,30976,33751</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37671675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Yuan</creatorcontrib><creatorcontrib>Sun, Huan</creatorcontrib><creatorcontrib>Lizano, Paulo</creatorcontrib><creatorcontrib>Deng, Gaoju</creatorcontrib><creatorcontrib>Zhou, Xiaoqin</creatorcontrib><creatorcontrib>Xie, Hongsheng</creatorcontrib><creatorcontrib>Mu, Jingshi</creatorcontrib><creatorcontrib>Long, Xipeng</creatorcontrib><creatorcontrib>Xiao, Hongqi</creatorcontrib><creatorcontrib>Liu, Shiyu</creatorcontrib><creatorcontrib>Wu, Baolin</creatorcontrib><creatorcontrib>Gong, Qiyong</creatorcontrib><creatorcontrib>Qiu, Changjian</creatorcontrib><creatorcontrib>Jia, Zhiyun</creatorcontrib><title>Effects of inflammation, childhood adversity, and psychiatric symptoms on brain morphometrical phenotypes in bipolar II depression</title><title>Psychological medicine</title><addtitle>Psychol Med</addtitle><description>The neuroanatomical alteration in bipolar II depression (BDII-D) and its associations with inflammation, childhood adversity, and psychiatric symptoms are currently unclear. We hypothesize that neuroanatomical deficits will be related to higher inflammation, greater childhood adversity, and worse psychiatric symptoms in BDII-D.
Voxel- and surface-based morphometry was performed using the CAT toolbox in 150 BDII-D patients and 155 healthy controls (HCs). Partial Pearson correlations followed by multiple comparison correction was used to indicate significant relationships between neuroanatomy and inflammation, childhood adversity, and psychiatric symptoms.
Compared with HCs, the BDII-D group demonstrated significantly smaller gray matter volumes (GMVs) in frontostriatal and fronto-cerebellar area, insula, rectus, and temporal gyrus, while significantly thinner cortices were found in frontal and temporal areas. In BDII-D, smaller GMV in the right middle frontal gyrus (MFG) was correlated with greater sexual abuse (
= -0.348,
< 0.001) while larger GMV in the right orbital MFG was correlated with greater physical neglect (
= 0.254,
= 0.03). Higher WBC count (
= -0.227,
= 0.015) and IL-6 levels (
= -0.266,
= 0.015) was associated with smaller GMVs in fronto-cerebellar area in BDII-D. Greater positive symptoms was correlated with larger GMVs of the left middle temporal pole (
= 0.245,
= 0.03).
Neuroanatomical alterations in frontostriatal and fronto-cerebellar area, insula, rectus, temporal gyrus volumes, and frontal-temporal thickness may reflect a core pathophysiological mechanism of BDII-D, which are related to inflammation, trauma, and psychiatric symptoms in BDII-D.</description><subject>Adverse Childhood Experiences</subject><subject>Adversity</subject><subject>Anatomy</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnostic imaging</subject><subject>Blood</subject><subject>Brain - diagnostic imaging</subject><subject>Brain architecture</subject><subject>Brain research</subject><subject>Cerebellum</subject><subject>Childhood</subject><subject>Children</subject><subject>Cytokines</subject><subject>Depression - diagnostic imaging</subject><subject>Frontal gyrus</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - diagnostic imaging</subject><subject>Lymphocytes</subject><subject>Magnetic Resonance Imaging</subject><subject>Mental depression</subject><subject>Morphometry</subject><subject>Neuroanatomy</subject><subject>Phenotypes</subject><subject>Psychiatric symptoms</subject><subject>Psychotropic drugs</subject><subject>Sexual abuse</subject><subject>Statistical analysis</subject><subject>Substantia grisea</subject><subject>Symptoms</subject><subject>Temporal gyrus</subject><subject>Time</subject><subject>Trauma</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>BHHNA</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplUT1rHDEQFcHGvtj-AWmCwE0Kb6yvlXZLY5zkwJDCdr3opBEns1op0l5gW__y6LhLCqcYpngfM4-H0CdKvlJC1e0TIZyznirGCWFCqQ9oRYXsm65X3Qla7eFmj5-jj6W8EkI5FewMnXMlFZWqXaG3B-fAzAVHh_3kRh2Cnn2cbrDZ-tFuY7RY29-Qi5-XG6wni1NZKqbn7A0uS0hzDFU-4U3WfsIh5rSNAfawHnHawhTnJUGp9njjUxx1xus1tpAylFJPXaJTp8cCV8d9gV6-PTzf_2gef35f3989NqZmnBsnDJUtd1Z0G-hbyp1h1mkFWjkuKes476020IIRXe-AC9Ck7ahhuq2pCb9AXw6-KcdfOyjzEHwxMI56grgrA-sklaKtU6nX76ivcZen-t3ACSe9lEywyqIHlsmxlAxuSNkHnZeBkmFf0PBfQVXz-ei82wSw_xR_G-F_ACG-jTo</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Cao, Yuan</creator><creator>Sun, Huan</creator><creator>Lizano, Paulo</creator><creator>Deng, Gaoju</creator><creator>Zhou, Xiaoqin</creator><creator>Xie, Hongsheng</creator><creator>Mu, Jingshi</creator><creator>Long, Xipeng</creator><creator>Xiao, Hongqi</creator><creator>Liu, Shiyu</creator><creator>Wu, Baolin</creator><creator>Gong, Qiyong</creator><creator>Qiu, Changjian</creator><creator>Jia, Zhiyun</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7U3</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHHNA</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1886-5654</orcidid><orcidid>https://orcid.org/0000-0002-1906-2530</orcidid><orcidid>https://orcid.org/0000-0002-3105-7654</orcidid></search><sort><creationdate>20240301</creationdate><title>Effects of inflammation, childhood adversity, and psychiatric symptoms on brain morphometrical phenotypes in bipolar II depression</title><author>Cao, Yuan ; Sun, Huan ; Lizano, Paulo ; Deng, Gaoju ; Zhou, Xiaoqin ; Xie, Hongsheng ; Mu, Jingshi ; Long, Xipeng ; Xiao, Hongqi ; Liu, Shiyu ; Wu, Baolin ; Gong, Qiyong ; Qiu, Changjian ; Jia, Zhiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-f4c1653fd48be9513fc2dfa7ea7f36128339dace5ec489fe34ea0581c2a514203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adverse Childhood Experiences</topic><topic>Adversity</topic><topic>Anatomy</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - diagnostic imaging</topic><topic>Blood</topic><topic>Brain - diagnostic imaging</topic><topic>Brain architecture</topic><topic>Brain research</topic><topic>Cerebellum</topic><topic>Childhood</topic><topic>Children</topic><topic>Cytokines</topic><topic>Depression - diagnostic imaging</topic><topic>Frontal gyrus</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - diagnostic imaging</topic><topic>Lymphocytes</topic><topic>Magnetic Resonance Imaging</topic><topic>Mental depression</topic><topic>Morphometry</topic><topic>Neuroanatomy</topic><topic>Phenotypes</topic><topic>Psychiatric symptoms</topic><topic>Psychotropic drugs</topic><topic>Sexual abuse</topic><topic>Statistical analysis</topic><topic>Substantia grisea</topic><topic>Symptoms</topic><topic>Temporal gyrus</topic><topic>Time</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Yuan</creatorcontrib><creatorcontrib>Sun, Huan</creatorcontrib><creatorcontrib>Lizano, Paulo</creatorcontrib><creatorcontrib>Deng, Gaoju</creatorcontrib><creatorcontrib>Zhou, Xiaoqin</creatorcontrib><creatorcontrib>Xie, Hongsheng</creatorcontrib><creatorcontrib>Mu, Jingshi</creatorcontrib><creatorcontrib>Long, Xipeng</creatorcontrib><creatorcontrib>Xiao, Hongqi</creatorcontrib><creatorcontrib>Liu, Shiyu</creatorcontrib><creatorcontrib>Wu, Baolin</creatorcontrib><creatorcontrib>Gong, Qiyong</creatorcontrib><creatorcontrib>Qiu, Changjian</creatorcontrib><creatorcontrib>Jia, Zhiyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Social Services Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Sociological Abstracts</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Yuan</au><au>Sun, Huan</au><au>Lizano, Paulo</au><au>Deng, Gaoju</au><au>Zhou, Xiaoqin</au><au>Xie, Hongsheng</au><au>Mu, Jingshi</au><au>Long, Xipeng</au><au>Xiao, Hongqi</au><au>Liu, Shiyu</au><au>Wu, Baolin</au><au>Gong, Qiyong</au><au>Qiu, Changjian</au><au>Jia, Zhiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of inflammation, childhood adversity, and psychiatric symptoms on brain morphometrical phenotypes in bipolar II depression</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol Med</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>54</volume><issue>4</issue><spage>775</spage><epage>784</epage><pages>775-784</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><abstract>The neuroanatomical alteration in bipolar II depression (BDII-D) and its associations with inflammation, childhood adversity, and psychiatric symptoms are currently unclear. We hypothesize that neuroanatomical deficits will be related to higher inflammation, greater childhood adversity, and worse psychiatric symptoms in BDII-D.
Voxel- and surface-based morphometry was performed using the CAT toolbox in 150 BDII-D patients and 155 healthy controls (HCs). Partial Pearson correlations followed by multiple comparison correction was used to indicate significant relationships between neuroanatomy and inflammation, childhood adversity, and psychiatric symptoms.
Compared with HCs, the BDII-D group demonstrated significantly smaller gray matter volumes (GMVs) in frontostriatal and fronto-cerebellar area, insula, rectus, and temporal gyrus, while significantly thinner cortices were found in frontal and temporal areas. In BDII-D, smaller GMV in the right middle frontal gyrus (MFG) was correlated with greater sexual abuse (
= -0.348,
< 0.001) while larger GMV in the right orbital MFG was correlated with greater physical neglect (
= 0.254,
= 0.03). Higher WBC count (
= -0.227,
= 0.015) and IL-6 levels (
= -0.266,
= 0.015) was associated with smaller GMVs in fronto-cerebellar area in BDII-D. Greater positive symptoms was correlated with larger GMVs of the left middle temporal pole (
= 0.245,
= 0.03).
Neuroanatomical alterations in frontostriatal and fronto-cerebellar area, insula, rectus, temporal gyrus volumes, and frontal-temporal thickness may reflect a core pathophysiological mechanism of BDII-D, which are related to inflammation, trauma, and psychiatric symptoms in BDII-D.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>37671675</pmid><doi>10.1017/S0033291723002477</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1886-5654</orcidid><orcidid>https://orcid.org/0000-0002-1906-2530</orcidid><orcidid>https://orcid.org/0000-0002-3105-7654</orcidid></addata></record> |
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| ispartof | Psychological medicine, 2024-03, Vol.54 (4), p.775-784 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Sociological Abstracts; Cambridge University Press Journals Complete |
| subjects | Adverse Childhood Experiences Adversity Anatomy Bipolar disorder Bipolar Disorder - diagnostic imaging Blood Brain - diagnostic imaging Brain architecture Brain research Cerebellum Childhood Children Cytokines Depression - diagnostic imaging Frontal gyrus Gray Matter - diagnostic imaging Humans Inflammation Inflammation - diagnostic imaging Lymphocytes Magnetic Resonance Imaging Mental depression Morphometry Neuroanatomy Phenotypes Psychiatric symptoms Psychotropic drugs Sexual abuse Statistical analysis Substantia grisea Symptoms Temporal gyrus Time Trauma |
| title | Effects of inflammation, childhood adversity, and psychiatric symptoms on brain morphometrical phenotypes in bipolar II depression |
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