Cryptococcal meningitis and cerebral vasculitis in a patient with primary intestinal lymphangiectasia: a case report
Primary intestinal lymphangiectasia (Waldmann’s disease) is a rare exudative enteropathy without precisely assessed infectious risk. We report the case of a 49-year-old male patient with meningitis and cerebral vasculitis due to Cryptococcus neoformans complicating Waldmann’s disease diagnosed 12 ye...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2023-10, Vol.42 (10), p.1263-1267 |
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| container_title | European journal of clinical microbiology & infectious diseases |
| container_volume | 42 |
| creator | Mathurin, Martin Devatine, Sandra Kopp-Derouet, Aude Guillonnet, Antoine Alanio, Alexandre Lourenco, Nelson Manda, Victoria Delcey, Véronique Molina, Jean-Michel Sellier, Pierre |
| description | Primary intestinal lymphangiectasia (Waldmann’s disease) is a rare exudative enteropathy without precisely assessed infectious risk. We report the case of a 49-year-old male patient with meningitis and cerebral vasculitis due to
Cryptococcus neoformans
complicating Waldmann’s disease diagnosed 12 years ago. The treatment combined liposomal amphotericin B, 3 mg/kg daily plus flucytosine 25 mg/kg/6 h, both intravenously during 15 days, then fluconazole 800 mg daily during 8 weeks, and finally 200 mg daily indefinitely. Dexamethasone 0.4 mg/kg daily during the first week was gradually decreased over 2 months. The outcome was good, and the patient is still followed 3 years later without any recurrence. |
| doi_str_mv | 10.1007/s10096-023-04657-y |
| format | Article |
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Cryptococcus neoformans
complicating Waldmann’s disease diagnosed 12 years ago. The treatment combined liposomal amphotericin B, 3 mg/kg daily plus flucytosine 25 mg/kg/6 h, both intravenously during 15 days, then fluconazole 800 mg daily during 8 weeks, and finally 200 mg daily indefinitely. Dexamethasone 0.4 mg/kg daily during the first week was gradually decreased over 2 months. The outcome was good, and the patient is still followed 3 years later without any recurrence.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-023-04657-y</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amphotericin B ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; Case reports ; Dexamethasone ; Exudation ; Fluconazole ; Flucytosine ; Fungi ; Hematology ; Infections ; Infectious diseases ; Internal Medicine ; Intestine ; Ischemia ; Lymphatic system ; Lymphocytes ; Magnetic resonance imaging ; Medical Microbiology ; Meningitis ; Vasculitis ; Veins & arteries</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2023-10, Vol.42 (10), p.1263-1267</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-7d08cc85da47484dc035a468670e0859d424d1ce18abf946c839ed01379641af3</cites><orcidid>0000-0002-9877-8165</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-023-04657-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-023-04657-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Mathurin, Martin</creatorcontrib><creatorcontrib>Devatine, Sandra</creatorcontrib><creatorcontrib>Kopp-Derouet, Aude</creatorcontrib><creatorcontrib>Guillonnet, Antoine</creatorcontrib><creatorcontrib>Alanio, Alexandre</creatorcontrib><creatorcontrib>Lourenco, Nelson</creatorcontrib><creatorcontrib>Manda, Victoria</creatorcontrib><creatorcontrib>Delcey, Véronique</creatorcontrib><creatorcontrib>Molina, Jean-Michel</creatorcontrib><creatorcontrib>Sellier, Pierre</creatorcontrib><title>Cryptococcal meningitis and cerebral vasculitis in a patient with primary intestinal lymphangiectasia: a case report</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Primary intestinal lymphangiectasia (Waldmann’s disease) is a rare exudative enteropathy without precisely assessed infectious risk. We report the case of a 49-year-old male patient with meningitis and cerebral vasculitis due to
Cryptococcus neoformans
complicating Waldmann’s disease diagnosed 12 years ago. The treatment combined liposomal amphotericin B, 3 mg/kg daily plus flucytosine 25 mg/kg/6 h, both intravenously during 15 days, then fluconazole 800 mg daily during 8 weeks, and finally 200 mg daily indefinitely. Dexamethasone 0.4 mg/kg daily during the first week was gradually decreased over 2 months. 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We report the case of a 49-year-old male patient with meningitis and cerebral vasculitis due to
Cryptococcus neoformans
complicating Waldmann’s disease diagnosed 12 years ago. The treatment combined liposomal amphotericin B, 3 mg/kg daily plus flucytosine 25 mg/kg/6 h, both intravenously during 15 days, then fluconazole 800 mg daily during 8 weeks, and finally 200 mg daily indefinitely. Dexamethasone 0.4 mg/kg daily during the first week was gradually decreased over 2 months. The outcome was good, and the patient is still followed 3 years later without any recurrence.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s10096-023-04657-y</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9877-8165</orcidid></addata></record> |
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| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2023-10, Vol.42 (10), p.1263-1267 |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Amphotericin B Biomedical and Life Sciences Biomedicine Brief Report Case reports Dexamethasone Exudation Fluconazole Flucytosine Fungi Hematology Infections Infectious diseases Internal Medicine Intestine Ischemia Lymphatic system Lymphocytes Magnetic resonance imaging Medical Microbiology Meningitis Vasculitis Veins & arteries |
| title | Cryptococcal meningitis and cerebral vasculitis in a patient with primary intestinal lymphangiectasia: a case report |
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