The effects of transcranial direct current stimulation on cognitive function for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials
Background Transcranial direct current stimulation (tDCS) emerged as a potential modality for enhancing cognitive functions in patients with cognitive decline, including mild cognitive impairment (MCI). Our systematic review and meta-analysis aim to synthesize the available randomized controlled tri...
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| Veröffentlicht in: | Aging clinical and experimental research 2023-11, Vol.35 (11), p.2293-2306 |
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| container_title | Aging clinical and experimental research |
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| creator | Saleh, Othman Assaf, Mohammad Alzoubi, Ahmad Anshase, Ahmad Tarkhan, Husam Ayoub, Motasem Abuelazm, Mohamed |
| description | Background
Transcranial direct current stimulation (tDCS) emerged as a potential modality for enhancing cognitive functions in patients with cognitive decline, including mild cognitive impairment (MCI). Our systematic review and meta-analysis aim to synthesize the available randomized controlled trials (RCTs) on the effects of tDCS on cognitive functions in patients with MCI.
Methods
Our review protocol was registered on PROSPERO with ID: CRD42022360587. We conducted a systematic database search until September 2022. Standardized mean difference (SMD) and pooled effect size (ES) for robust variance estimation (RVE) method were used as effect estimates for our meta-analysis.
Results
We included 11 RCTs with a total of 429 participants. The meta-analysis showed that, compared to sham groups, tDCS did not improve global functioning (measured by MOCA) (SMD = 0.02, CI = − 0.30 to 0.35;
p =
0.88), memory domain (ES = 0.681, CI = − 2.15 to 3.51,
p =
0.576), sustained attention (measured by TMT-A) (SMD = − 0.21, CI = − 0.52 to 0.10,
p =
0.19), and executive function (measured by TMT-B) (SMD = − 0.53, CI = − 1.56 to 0.50,
p =
0.20).
Conclusion
Our meta-analysis found no significant effect of tDCS on cognitive functions in MCI patients, including effects on global functioning, memory, sustained attention, and executive function. Therefore, an important change to be tested in future studies is to look for a better combination with tDCS for patients with MCI. |
| doi_str_mv | 10.1007/s40520-023-02528-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2861304861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2861304861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-708cbe3d1bce32fdc37bc1391f03d3ec086099a844d78aa9984bdde4fb18aab73</originalsourceid><addsrcrecordid>eNp9UU1vFSEUJcYm1mf_gCsSN25G-Zg3w7gzjbUmTdzUNWHgUmkGeAJT8_xX_kPve6-JjQsT4H5wzuGSQ8hrzt5xxsb3tWdbwTomJO6tUJ14Rs75iC0l-fT8Sf6CvKz1nrGeY3FOft9-Bwreg22VZk9bMalaPIJZqAsF-9SupUBqtLYQ18W0kBPFZfNdCi08APVrsseuz4XGsLgndyHuTCgR-R-ooXVfG0SUsLTAQ4Cf1CRHIzTTmWSWfQ3HKfB9l2P4BQel1EpeFkxbwaHqK3LmMcDFY9yQb1efbi-vu5uvn79cfrzprNyK1o1M2Rmk47MFKbyzcpwtlxP3TDoJlqmBTZNRfe9GZcw0qX52Dno_cyznUW7I25PuruQfK9SmY6gWlsUkyGvVQg1csv5wbsibf6D3eS34nwNKDf0wKCERJU4oW3KtBbzelRBN2WvO9MFFfXJRo4v66KIWSJInUkVwuoPyV_o_rD8dwKVL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2886466823</pqid></control><display><type>article</type><title>The effects of transcranial direct current stimulation on cognitive function for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials</title><source>SpringerLink Journals - AutoHoldings</source><creator>Saleh, Othman ; Assaf, Mohammad ; Alzoubi, Ahmad ; Anshase, Ahmad ; Tarkhan, Husam ; Ayoub, Motasem ; Abuelazm, Mohamed</creator><creatorcontrib>Saleh, Othman ; Assaf, Mohammad ; Alzoubi, Ahmad ; Anshase, Ahmad ; Tarkhan, Husam ; Ayoub, Motasem ; Abuelazm, Mohamed</creatorcontrib><description>Background
Transcranial direct current stimulation (tDCS) emerged as a potential modality for enhancing cognitive functions in patients with cognitive decline, including mild cognitive impairment (MCI). Our systematic review and meta-analysis aim to synthesize the available randomized controlled trials (RCTs) on the effects of tDCS on cognitive functions in patients with MCI.
Methods
Our review protocol was registered on PROSPERO with ID: CRD42022360587. We conducted a systematic database search until September 2022. Standardized mean difference (SMD) and pooled effect size (ES) for robust variance estimation (RVE) method were used as effect estimates for our meta-analysis.
Results
We included 11 RCTs with a total of 429 participants. The meta-analysis showed that, compared to sham groups, tDCS did not improve global functioning (measured by MOCA) (SMD = 0.02, CI = − 0.30 to 0.35;
p =
0.88), memory domain (ES = 0.681, CI = − 2.15 to 3.51,
p =
0.576), sustained attention (measured by TMT-A) (SMD = − 0.21, CI = − 0.52 to 0.10,
p =
0.19), and executive function (measured by TMT-B) (SMD = − 0.53, CI = − 1.56 to 0.50,
p =
0.20).
Conclusion
Our meta-analysis found no significant effect of tDCS on cognitive functions in MCI patients, including effects on global functioning, memory, sustained attention, and executive function. Therefore, an important change to be tested in future studies is to look for a better combination with tDCS for patients with MCI.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-023-02528-2</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Clinical trials ; Cognitive ability ; Executive function ; Geriatrics/Gerontology ; Medicine ; Medicine & Public Health ; Meta-analysis ; Review ; Systematic review</subject><ispartof>Aging clinical and experimental research, 2023-11, Vol.35 (11), p.2293-2306</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-708cbe3d1bce32fdc37bc1391f03d3ec086099a844d78aa9984bdde4fb18aab73</citedby><cites>FETCH-LOGICAL-c352t-708cbe3d1bce32fdc37bc1391f03d3ec086099a844d78aa9984bdde4fb18aab73</cites><orcidid>0000-0002-2514-0689</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-023-02528-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-023-02528-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Saleh, Othman</creatorcontrib><creatorcontrib>Assaf, Mohammad</creatorcontrib><creatorcontrib>Alzoubi, Ahmad</creatorcontrib><creatorcontrib>Anshase, Ahmad</creatorcontrib><creatorcontrib>Tarkhan, Husam</creatorcontrib><creatorcontrib>Ayoub, Motasem</creatorcontrib><creatorcontrib>Abuelazm, Mohamed</creatorcontrib><title>The effects of transcranial direct current stimulation on cognitive function for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><description>Background
Transcranial direct current stimulation (tDCS) emerged as a potential modality for enhancing cognitive functions in patients with cognitive decline, including mild cognitive impairment (MCI). Our systematic review and meta-analysis aim to synthesize the available randomized controlled trials (RCTs) on the effects of tDCS on cognitive functions in patients with MCI.
Methods
Our review protocol was registered on PROSPERO with ID: CRD42022360587. We conducted a systematic database search until September 2022. Standardized mean difference (SMD) and pooled effect size (ES) for robust variance estimation (RVE) method were used as effect estimates for our meta-analysis.
Results
We included 11 RCTs with a total of 429 participants. The meta-analysis showed that, compared to sham groups, tDCS did not improve global functioning (measured by MOCA) (SMD = 0.02, CI = − 0.30 to 0.35;
p =
0.88), memory domain (ES = 0.681, CI = − 2.15 to 3.51,
p =
0.576), sustained attention (measured by TMT-A) (SMD = − 0.21, CI = − 0.52 to 0.10,
p =
0.19), and executive function (measured by TMT-B) (SMD = − 0.53, CI = − 1.56 to 0.50,
p =
0.20).
Conclusion
Our meta-analysis found no significant effect of tDCS on cognitive functions in MCI patients, including effects on global functioning, memory, sustained attention, and executive function. Therefore, an important change to be tested in future studies is to look for a better combination with tDCS for patients with MCI.</description><subject>Clinical trials</subject><subject>Cognitive ability</subject><subject>Executive function</subject><subject>Geriatrics/Gerontology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Review</subject><subject>Systematic review</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9UU1vFSEUJcYm1mf_gCsSN25G-Zg3w7gzjbUmTdzUNWHgUmkGeAJT8_xX_kPve6-JjQsT4H5wzuGSQ8hrzt5xxsb3tWdbwTomJO6tUJ14Rs75iC0l-fT8Sf6CvKz1nrGeY3FOft9-Bwreg22VZk9bMalaPIJZqAsF-9SupUBqtLYQ18W0kBPFZfNdCi08APVrsseuz4XGsLgndyHuTCgR-R-ooXVfG0SUsLTAQ4Cf1CRHIzTTmWSWfQ3HKfB9l2P4BQel1EpeFkxbwaHqK3LmMcDFY9yQb1efbi-vu5uvn79cfrzprNyK1o1M2Rmk47MFKbyzcpwtlxP3TDoJlqmBTZNRfe9GZcw0qX52Dno_cyznUW7I25PuruQfK9SmY6gWlsUkyGvVQg1csv5wbsibf6D3eS34nwNKDf0wKCERJU4oW3KtBbzelRBN2WvO9MFFfXJRo4v66KIWSJInUkVwuoPyV_o_rD8dwKVL</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Saleh, Othman</creator><creator>Assaf, Mohammad</creator><creator>Alzoubi, Ahmad</creator><creator>Anshase, Ahmad</creator><creator>Tarkhan, Husam</creator><creator>Ayoub, Motasem</creator><creator>Abuelazm, Mohamed</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2514-0689</orcidid></search><sort><creationdate>20231101</creationdate><title>The effects of transcranial direct current stimulation on cognitive function for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials</title><author>Saleh, Othman ; Assaf, Mohammad ; Alzoubi, Ahmad ; Anshase, Ahmad ; Tarkhan, Husam ; Ayoub, Motasem ; Abuelazm, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-708cbe3d1bce32fdc37bc1391f03d3ec086099a844d78aa9984bdde4fb18aab73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Clinical trials</topic><topic>Cognitive ability</topic><topic>Executive function</topic><topic>Geriatrics/Gerontology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Review</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saleh, Othman</creatorcontrib><creatorcontrib>Assaf, Mohammad</creatorcontrib><creatorcontrib>Alzoubi, Ahmad</creatorcontrib><creatorcontrib>Anshase, Ahmad</creatorcontrib><creatorcontrib>Tarkhan, Husam</creatorcontrib><creatorcontrib>Ayoub, Motasem</creatorcontrib><creatorcontrib>Abuelazm, Mohamed</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saleh, Othman</au><au>Assaf, Mohammad</au><au>Alzoubi, Ahmad</au><au>Anshase, Ahmad</au><au>Tarkhan, Husam</au><au>Ayoub, Motasem</au><au>Abuelazm, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of transcranial direct current stimulation on cognitive function for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><date>2023-11-01</date><risdate>2023</risdate><volume>35</volume><issue>11</issue><spage>2293</spage><epage>2306</epage><pages>2293-2306</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Transcranial direct current stimulation (tDCS) emerged as a potential modality for enhancing cognitive functions in patients with cognitive decline, including mild cognitive impairment (MCI). Our systematic review and meta-analysis aim to synthesize the available randomized controlled trials (RCTs) on the effects of tDCS on cognitive functions in patients with MCI.
Methods
Our review protocol was registered on PROSPERO with ID: CRD42022360587. We conducted a systematic database search until September 2022. Standardized mean difference (SMD) and pooled effect size (ES) for robust variance estimation (RVE) method were used as effect estimates for our meta-analysis.
Results
We included 11 RCTs with a total of 429 participants. The meta-analysis showed that, compared to sham groups, tDCS did not improve global functioning (measured by MOCA) (SMD = 0.02, CI = − 0.30 to 0.35;
p =
0.88), memory domain (ES = 0.681, CI = − 2.15 to 3.51,
p =
0.576), sustained attention (measured by TMT-A) (SMD = − 0.21, CI = − 0.52 to 0.10,
p =
0.19), and executive function (measured by TMT-B) (SMD = − 0.53, CI = − 1.56 to 0.50,
p =
0.20).
Conclusion
Our meta-analysis found no significant effect of tDCS on cognitive functions in MCI patients, including effects on global functioning, memory, sustained attention, and executive function. Therefore, an important change to be tested in future studies is to look for a better combination with tDCS for patients with MCI.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40520-023-02528-2</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-2514-0689</orcidid></addata></record> |
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| ispartof | Aging clinical and experimental research, 2023-11, Vol.35 (11), p.2293-2306 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Clinical trials Cognitive ability Executive function Geriatrics/Gerontology Medicine Medicine & Public Health Meta-analysis Review Systematic review |
| title | The effects of transcranial direct current stimulation on cognitive function for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials |
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