Multi-attribute analysis of adeno-associated virus by size exclusion chromatography with fluorescence and triple-wavelength UV detection

Adeno-associated virus (AAV) is the leading platform for in vivo gene therapy to treat numerous genetic diseases. Comprehensive analysis of the AAV particles is essential to ensure desired safety and efficacy. An array of techniques is required to evaluate their critical quality attributes. However,...

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Veröffentlicht in:	Analytical biochemistry 2023-11, Vol.680, p.115311-115311, Article 115311
Hauptverfasser:	Xie, Yongjing, Butler, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Empty and full capsids Gene therapy Multi-attribute analysis Size exclusion chromatography Viral vector
Online-Zugang:	Volltext
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