Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys

Severe diarrhea is a common side effect of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). We aimed to evaluate the risk of EGFR-TKI-induced diarrhea using spheroids of human and monkey crypt-derived intestinal stem cells. Intestinal spheroids exhibited higher toxic suscepti...

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Veröffentlicht in:	Toxicology in vitro 2023-12, Vol.93, p.105691-105691, Article 105691
Hauptverfasser:	Hashimoto, Yoshiki, Maeda, Kazuya, Shimomura, Osamu, Miyazaki, Yoshihiro, Hashimoto, Shinji, Moriyama, Akiko, Oda, Tatsuya, Kusuhara, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate Afatinib - therapeutic use Afatinib - toxicity Animals Antineoplastic Agents - pharmacology Caco-2 Cells Carcinoma, Non-Small-Cell Lung - drug therapy Diarrhea Diarrhea - chemically induced Epidermal growth factor receptor tyrosine kinase inhibitors ErbB Receptors - metabolism Gastrointestinal toxicity Haplorhini - metabolism Humans Intestinal spheroids Lung Neoplasms - drug therapy Mutation Protein Kinase Inhibitors - toxicity Tyrosine Kinase Inhibitors
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