Design, synthesis, and antitumor screening of new thiazole, thiazolopyrimidine, and thiazolotriazine derivatives as potent inhibitors of VEGFR‐2

New thiazole, thiazolopyrimidine, and thiazolotriazine derivatives 3–12 and 14a–f were synthesized. The newly synthesized analogs were tested for in vitro antitumor activity against HepG2, HCT‐116, MCF‐7, HeP‐2, and Hela cancer cells. Results indicated that compound 5 displayed the highest potency t...

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Veröffentlicht in:	Drug development research 2023-12, Vol.84 (8), p.1664-1698
Hauptverfasser:	Abd Elhameed, Alaa A., Ali, Ahmed R., Ghabbour, Hazem A., Bayomi, Said M., El‐Gohary, Nadia S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties antitumor Antitumor activity Apoptosis Bioavailability Cancer Cell cycle Cell death Chemical bonds Cytotoxicity Doxorubicin Growth factors S phase Synthesis thiazoles and fused thiazoles Toxicity Tumor cell lines Vascular endothelial growth factor Vascular endothelial growth factor receptors VEGFR‐2 inhibition
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