Potential Interaction between Sodium Polystyrene Sulfonate and Prescription Drugs in Artificial Intestinal Juice

Potential Interaction between Sodium Polystyrene Sulfonate and Prescription Drugs in Artificial Intestinal Juice

This study evaluated the interaction between sodium polystyrene sulfonate (SPS) and several commonly used concomitant drugs, such as carvedilol, bisoprolol, imidapril, atorvastatin and azilsartan. The residual rate of adsorption 6 h after starting the experiment followed the order carvedilol (0.36%)...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2023/09/01, Vol.71(9), pp.751-755
Hauptverfasser: Mizuno, Yuri, Uematsu, Yugo, Nishida, Kyohei, Ogata, Fumihiko, Kawasaki, Naohito
Format: Artikel
Sprache:eng
Schlagworte:
Adsorption
Atorvastatin
Drugs
Intestine
Ions
Juices
Polystyrene
Polystyrene resins
Potassium
potassium ion
Prescription drugs
Sodium polystyrene sulfonate
β-blocker drug
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Beschreibung
Zusammenfassung:This study evaluated the interaction between sodium polystyrene sulfonate (SPS) and several commonly used concomitant drugs, such as carvedilol, bisoprolol, imidapril, atorvastatin and azilsartan. The residual rate of adsorption 6 h after starting the experiment followed the order carvedilol (0.36%) 
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.c23-00429