The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila

In mammals, the enzyme cGAS senses the presence of cytosolic DNA and synthesizes the cyclic dinucleotide (CDN) 2'3'-cGAMP, which triggers STING-dependent immunity. In Drosophila melanogaster, two cGAS-like receptors (cGLRs) produce 3'2'-cGAMP and 2'3'-cGAMP to activate...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2023-09, Vol.56 (9), p.1991
Hauptverfasser:	Cai, Hua, Li, Lihua, Slavik, Kailey M, Huang, Jingxian, Yin, Ting, Ai, Xianlong, Hédelin, Léna, Haas, Gabrielle, Xiang, Zhangmin, Yang, Yunyun, Li, Xiaoyan, Chen, Yuqiang, Wei, Ziming, Deng, Huimin, Chen, Di, Jiao, Renjie, Martins, Nelson, Meignin, Carine, Kranzusch, Philip J, Imler, Jean-Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic GMP Drosophila Drosophila melanogaster Mammals
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