The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study
Our aim was to investigate the effects of endogenous chronic hypercortisolism on sleep electroencephalogram (EEG) and differences between the adrenocorticotropic hormone (ACTH)-dependent and independent Cushing Syndrome (CS) patients through a sleep spectral analysis program. A total of 32 patients...
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| Veröffentlicht in: | Neurophysiologie clinique 2023-10, Vol.53 (5), p.102893-102893, Article 102893 |
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| container_title | Neurophysiologie clinique |
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| creator | Kurt Gok, Duygu İsmailogullari, Sevda Aldemir, Ramazan Tokmakci, Mahmut Firat, Sedat Tarik Karaca, Zuleyha Kelestimur, Fahrettin Zararsiz, Gokmen |
| description | Our aim was to investigate the effects of endogenous chronic hypercortisolism on sleep electroencephalogram (EEG) and differences between the adrenocorticotropic hormone (ACTH)-dependent and independent Cushing Syndrome (CS) patients through a sleep spectral analysis program.
A total of 32 patients diagnosed as having endogenous CS (12 ACTH-dependent and 20 ACTH-independent) and a control group comprising 16 healthy individuals were included in the study. Polysomnographic analysis was performed. Blood samples were collected at 08:00 AM for analysis of ACTH and basal cortisol, and at 00:00 AM for midnight cortisol levels. The frequency and power of the slow wave activity (SWA), theta, alpha, and beta waves of the first and last non-rapid eye movement (NREM) cycles were measured with a spectral analysis program.
The CS patient group had higher SWA power, especially in the first NREM cycle. In the ACTH-dependent group, SWA maximum and mean power values were higher in the frontal channels in the first NREM, compared to the last NREM sleep stage (p |
| doi_str_mv | 10.1016/j.neucli.2023.102893 |
| format | Article |
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A total of 32 patients diagnosed as having endogenous CS (12 ACTH-dependent and 20 ACTH-independent) and a control group comprising 16 healthy individuals were included in the study. Polysomnographic analysis was performed. Blood samples were collected at 08:00 AM for analysis of ACTH and basal cortisol, and at 00:00 AM for midnight cortisol levels. The frequency and power of the slow wave activity (SWA), theta, alpha, and beta waves of the first and last non-rapid eye movement (NREM) cycles were measured with a spectral analysis program.
The CS patient group had higher SWA power, especially in the first NREM cycle. In the ACTH-dependent group, SWA maximum and mean power values were higher in the frontal channels in the first NREM, compared to the last NREM sleep stage (p<0.05).
Cortisol has been found to be associated with SWA waves, making these waves higher in power, especially in the first NREM phase. This difference was much less pronounced in the final NREM sleep stage. The difference between the first and last NREM sleep stages with respect to the power of SWA in the frontal channel in the ACTH-dependent group suggests that not only cortisol but also high levels of ACTH affect the power of slow waves during sleep.</description><identifier>ISSN: 0987-7053</identifier><identifier>EISSN: 1769-7131</identifier><identifier>DOI: 10.1016/j.neucli.2023.102893</identifier><language>eng</language><publisher>Elsevier Masson SAS</publisher><subject>Adrenocorticotropic hormone ; Cortisol ; Cushing syndrome ; Sleep electroencephalogram ; Spectral analysis</subject><ispartof>Neurophysiologie clinique, 2023-10, Vol.53 (5), p.102893-102893, Article 102893</ispartof><rights>2023 Elsevier Masson SAS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c288t-9d638159f6055ff8d2d205d968a659090bc92513d411e41553b8aa0c5a7d47dc3</cites><orcidid>0000-0003-0994-0325</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neucli.2023.102893$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Kurt Gok, Duygu</creatorcontrib><creatorcontrib>İsmailogullari, Sevda</creatorcontrib><creatorcontrib>Aldemir, Ramazan</creatorcontrib><creatorcontrib>Tokmakci, Mahmut</creatorcontrib><creatorcontrib>Firat, Sedat Tarik</creatorcontrib><creatorcontrib>Karaca, Zuleyha</creatorcontrib><creatorcontrib>Kelestimur, Fahrettin</creatorcontrib><creatorcontrib>Zararsiz, Gokmen</creatorcontrib><title>The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study</title><title>Neurophysiologie clinique</title><description>Our aim was to investigate the effects of endogenous chronic hypercortisolism on sleep electroencephalogram (EEG) and differences between the adrenocorticotropic hormone (ACTH)-dependent and independent Cushing Syndrome (CS) patients through a sleep spectral analysis program.
A total of 32 patients diagnosed as having endogenous CS (12 ACTH-dependent and 20 ACTH-independent) and a control group comprising 16 healthy individuals were included in the study. Polysomnographic analysis was performed. Blood samples were collected at 08:00 AM for analysis of ACTH and basal cortisol, and at 00:00 AM for midnight cortisol levels. The frequency and power of the slow wave activity (SWA), theta, alpha, and beta waves of the first and last non-rapid eye movement (NREM) cycles were measured with a spectral analysis program.
The CS patient group had higher SWA power, especially in the first NREM cycle. In the ACTH-dependent group, SWA maximum and mean power values were higher in the frontal channels in the first NREM, compared to the last NREM sleep stage (p<0.05).
Cortisol has been found to be associated with SWA waves, making these waves higher in power, especially in the first NREM phase. This difference was much less pronounced in the final NREM sleep stage. The difference between the first and last NREM sleep stages with respect to the power of SWA in the frontal channel in the ACTH-dependent group suggests that not only cortisol but also high levels of ACTH affect the power of slow waves during sleep.</description><subject>Adrenocorticotropic hormone</subject><subject>Cortisol</subject><subject>Cushing syndrome</subject><subject>Sleep electroencephalogram</subject><subject>Spectral analysis</subject><issn>0987-7053</issn><issn>1769-7131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kMFq3DAURUVpINO0f5CFlt14KlmWLXVRCMM0LQS6SddCkZ4zGmzJ1bMT_BP55mpw110JHvcecQ8ht5ztOePtl_M-wuKGsK9ZLcqpVlq8IzvetbrquODvyY5p1VUdk-KafEA8M8YaocWOvD2egELfg5uRpp6e1gmyS3kOmIaAI02RziXSZ_izQHQrtdHT0T7HMC8eLhUcACZ6PN7TV_sCSEOkk50DxEJ8DfOJHhY8hfhMcY0-pxG-0juKU_kx26Hg7LBiQIqFt34kV70dED79e2_I7-_Hx8OP6uHX_c_D3UPlaqXmSvtWKC513zIp-1752tdMet0q20rNNHtyupZc-IZzaLiU4klZy5y0nW8678QN-bxxp5zKLpzNGNDBMNgIaUFTq5Y1rBOyK9Fmi7qcEDP0ZsphtHk1nJmLfnM2m35z0W82_aX2batBmfESIBt0xYkDH3KZbnwK_wf8BdD8keA</recordid><startdate>202310</startdate><enddate>202310</enddate><creator>Kurt Gok, Duygu</creator><creator>İsmailogullari, Sevda</creator><creator>Aldemir, Ramazan</creator><creator>Tokmakci, Mahmut</creator><creator>Firat, Sedat Tarik</creator><creator>Karaca, Zuleyha</creator><creator>Kelestimur, Fahrettin</creator><creator>Zararsiz, Gokmen</creator><general>Elsevier Masson SAS</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0994-0325</orcidid></search><sort><creationdate>202310</creationdate><title>The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study</title><author>Kurt Gok, Duygu ; İsmailogullari, Sevda ; Aldemir, Ramazan ; Tokmakci, Mahmut ; Firat, Sedat Tarik ; Karaca, Zuleyha ; Kelestimur, Fahrettin ; Zararsiz, Gokmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-9d638159f6055ff8d2d205d968a659090bc92513d411e41553b8aa0c5a7d47dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adrenocorticotropic hormone</topic><topic>Cortisol</topic><topic>Cushing syndrome</topic><topic>Sleep electroencephalogram</topic><topic>Spectral analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurt Gok, Duygu</creatorcontrib><creatorcontrib>İsmailogullari, Sevda</creatorcontrib><creatorcontrib>Aldemir, Ramazan</creatorcontrib><creatorcontrib>Tokmakci, Mahmut</creatorcontrib><creatorcontrib>Firat, Sedat Tarik</creatorcontrib><creatorcontrib>Karaca, Zuleyha</creatorcontrib><creatorcontrib>Kelestimur, Fahrettin</creatorcontrib><creatorcontrib>Zararsiz, Gokmen</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurophysiologie clinique</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurt Gok, Duygu</au><au>İsmailogullari, Sevda</au><au>Aldemir, Ramazan</au><au>Tokmakci, Mahmut</au><au>Firat, Sedat Tarik</au><au>Karaca, Zuleyha</au><au>Kelestimur, Fahrettin</au><au>Zararsiz, Gokmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study</atitle><jtitle>Neurophysiologie clinique</jtitle><date>2023-10</date><risdate>2023</risdate><volume>53</volume><issue>5</issue><spage>102893</spage><epage>102893</epage><pages>102893-102893</pages><artnum>102893</artnum><issn>0987-7053</issn><eissn>1769-7131</eissn><abstract>Our aim was to investigate the effects of endogenous chronic hypercortisolism on sleep electroencephalogram (EEG) and differences between the adrenocorticotropic hormone (ACTH)-dependent and independent Cushing Syndrome (CS) patients through a sleep spectral analysis program.
A total of 32 patients diagnosed as having endogenous CS (12 ACTH-dependent and 20 ACTH-independent) and a control group comprising 16 healthy individuals were included in the study. Polysomnographic analysis was performed. Blood samples were collected at 08:00 AM for analysis of ACTH and basal cortisol, and at 00:00 AM for midnight cortisol levels. The frequency and power of the slow wave activity (SWA), theta, alpha, and beta waves of the first and last non-rapid eye movement (NREM) cycles were measured with a spectral analysis program.
The CS patient group had higher SWA power, especially in the first NREM cycle. In the ACTH-dependent group, SWA maximum and mean power values were higher in the frontal channels in the first NREM, compared to the last NREM sleep stage (p<0.05).
Cortisol has been found to be associated with SWA waves, making these waves higher in power, especially in the first NREM phase. This difference was much less pronounced in the final NREM sleep stage. The difference between the first and last NREM sleep stages with respect to the power of SWA in the frontal channel in the ACTH-dependent group suggests that not only cortisol but also high levels of ACTH affect the power of slow waves during sleep.</abstract><pub>Elsevier Masson SAS</pub><doi>10.1016/j.neucli.2023.102893</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0994-0325</orcidid></addata></record> |
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| subjects | Adrenocorticotropic hormone Cortisol Cushing syndrome Sleep electroencephalogram Spectral analysis |
| title | The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study |
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