HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

Ischemia-reperfusion injury (IRI) poses a significant challenge to liver transplantation (LT). The underlying mechanism primarily involves overactivation of the immune system. Heat shock protein 110 (HSP110) functions as a molecular chaperone that helps stabilize protein structures. An IRI model was...

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Veröffentlicht in:	Hepatobiliary & pancreatic diseases international 2024-08, Vol.23 (4), p.344-352
Hauptverfasser:	Hu, Qing-Zhi, Cao, Zhen-Rui, Zheng, Wei-Xiong, Zhao, Min-Jie, Gong, Jun-Hua, Chen, Cong, Wu, Zhong-Jun, Tao, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Disease Models, Animal HSP110 Heat-Shock Proteins - genetics HSP110 Heat-Shock Proteins - metabolism Inflammation Mediators - metabolism Kupffer Cells - metabolism Liver - metabolism Liver - pathology Liver Transplantation - adverse effects Male NF-kappa B - metabolism Rats, Sprague-Dawley Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control RNA Interference Signal Transduction Transfection
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