Efficacy and Safety of Pressure Therapy Alone and in Combination with Silicone in Prevention of Hypertrophic Scars: A Systematic Review with Meta-analysis of Randomized Controlled Trials
Background At present, there are many kinds of hypertrophic scar treatment methods, among which pressure therapy and silicone therapy are very common and standard therapies, but whether they are used alone or in combination is still controversial. Therefore, the purpose of this systematic review was...
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| Veröffentlicht in: | Aesthetic plastic surgery 2023-10, Vol.47 (5), p.2159-2174 |
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| creator | Zhang, Peixuan Wu, Qian Ding, Hongfan Bai, Ruiqi Meng, Fanting Xu, Xiao Chen, Minliang |
| description | Background
At present, there are many kinds of hypertrophic scar treatment methods, among which pressure therapy and silicone therapy are very common and standard therapies, but whether they are used alone or in combination is still controversial. Therefore, the purpose of this systematic review was to compare the efficacy and safety of the combination of pressure therapy and silicone therapy (PTS) with pressure therapy alone (PT) in the treatment of hypertrophic scars to provide clinicians with information so that they can make better decisions.
Methods
Relevant randomized controlled trials (RCTs) were collected by searching PubMed, Ovid MEDLINE, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scopus, and Google Scholar databases to assess scar scores (The Vancouver Scar Scale, VSS; Visual Analog Scale, VAS) and adverse effects.
Results
We screened 1270 articles and included 6 RCTs including 228 patients. We found that height (MD = 0.15, 95%CI 0.10–0.21,
p
< 0.01) and pliability (MD = 0.35, 95%CI 0.25–0.46,
p |
| doi_str_mv | 10.1007/s00266-023-03591-w |
| format | Article |
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At present, there are many kinds of hypertrophic scar treatment methods, among which pressure therapy and silicone therapy are very common and standard therapies, but whether they are used alone or in combination is still controversial. Therefore, the purpose of this systematic review was to compare the efficacy and safety of the combination of pressure therapy and silicone therapy (PTS) with pressure therapy alone (PT) in the treatment of hypertrophic scars to provide clinicians with information so that they can make better decisions.
Methods
Relevant randomized controlled trials (RCTs) were collected by searching PubMed, Ovid MEDLINE, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scopus, and Google Scholar databases to assess scar scores (The Vancouver Scar Scale, VSS; Visual Analog Scale, VAS) and adverse effects.
Results
We screened 1270 articles and included 6 RCTs including 228 patients. We found that height (MD = 0.15, 95%CI 0.10–0.21,
p
< 0.01) and pliability (MD = 0.35, 95%CI 0.25–0.46,
p
<0.01) had a significant difference, these two measures showed that the PTS group was superior to the PT group. Results in other aspects, such as VSS, vascularity, pigmentation, VAS, and adverse effects were similar between the two groups.
Conclusions
There was no significant difference between PTS and PT in the overall treatment efficacy of hypertrophic scars with similar VSS and adverse effects, but PTS might have potential benefits for height and pliability. Additional studies with larger sample size and sound methodological quality are needed to confirm our conclusions.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><identifier>ISSN: 0364-216X</identifier><identifier>EISSN: 1432-5241</identifier><identifier>DOI: 10.1007/s00266-023-03591-w</identifier><identifier>PMID: 37648929</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cicatrix, Hypertrophic - pathology ; Cicatrix, Hypertrophic - prevention & control ; Clinical trials ; Humans ; Medicine ; Medicine & Public Health ; Meta-analysis ; Otorhinolaryngology ; Plastic Surgery ; Randomized Controlled Trials as Topic ; Review ; Silicones ; Systematic review ; Treatment Outcome</subject><ispartof>Aesthetic plastic surgery, 2023-10, Vol.47 (5), p.2159-2174</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-d1206b0f078f4ce3e8c52ae5a680567481baf1bfb3f868506b28e6d955fd5b9f3</citedby><cites>FETCH-LOGICAL-c375t-d1206b0f078f4ce3e8c52ae5a680567481baf1bfb3f868506b28e6d955fd5b9f3</cites><orcidid>0000-0002-6413-5786</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00266-023-03591-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00266-023-03591-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37648929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Peixuan</creatorcontrib><creatorcontrib>Wu, Qian</creatorcontrib><creatorcontrib>Ding, Hongfan</creatorcontrib><creatorcontrib>Bai, Ruiqi</creatorcontrib><creatorcontrib>Meng, Fanting</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Chen, Minliang</creatorcontrib><title>Efficacy and Safety of Pressure Therapy Alone and in Combination with Silicone in Prevention of Hypertrophic Scars: A Systematic Review with Meta-analysis of Randomized Controlled Trials</title><title>Aesthetic plastic surgery</title><addtitle>Aesth Plast Surg</addtitle><addtitle>Aesthetic Plast Surg</addtitle><description>Background
At present, there are many kinds of hypertrophic scar treatment methods, among which pressure therapy and silicone therapy are very common and standard therapies, but whether they are used alone or in combination is still controversial. Therefore, the purpose of this systematic review was to compare the efficacy and safety of the combination of pressure therapy and silicone therapy (PTS) with pressure therapy alone (PT) in the treatment of hypertrophic scars to provide clinicians with information so that they can make better decisions.
Methods
Relevant randomized controlled trials (RCTs) were collected by searching PubMed, Ovid MEDLINE, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scopus, and Google Scholar databases to assess scar scores (The Vancouver Scar Scale, VSS; Visual Analog Scale, VAS) and adverse effects.
Results
We screened 1270 articles and included 6 RCTs including 228 patients. We found that height (MD = 0.15, 95%CI 0.10–0.21,
p
< 0.01) and pliability (MD = 0.35, 95%CI 0.25–0.46,
p
<0.01) had a significant difference, these two measures showed that the PTS group was superior to the PT group. Results in other aspects, such as VSS, vascularity, pigmentation, VAS, and adverse effects were similar between the two groups.
Conclusions
There was no significant difference between PTS and PT in the overall treatment efficacy of hypertrophic scars with similar VSS and adverse effects, but PTS might have potential benefits for height and pliability. Additional studies with larger sample size and sound methodological quality are needed to confirm our conclusions.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><subject>Cicatrix, Hypertrophic - pathology</subject><subject>Cicatrix, Hypertrophic - prevention & control</subject><subject>Clinical trials</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Review</subject><subject>Silicones</subject><subject>Systematic review</subject><subject>Treatment Outcome</subject><issn>0364-216X</issn><issn>1432-5241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1DAURi0EotPCC7BAltiwCfgndhx2o1GhSEWgziCxixznmnGVOMFOOgqP1qfDMykgsWB1Ld3znSvrQ-gFJW8oIcXbSAiTMiOMZ4SLkmaHR2hFc84ywXL6GK0Il3nGqPx2hs5jvCWEsqLIn6IzXshclaxcoftLa53RZsbaN3irLYwz7i3-EiDGKQDe7SHoYcbrtvdwgpzHm76rndej6z0-uHGPt6515gikZYregT_tkuhqHiCMoR_2zuCt0SG-w2u8neMIXRIYfAN3Dg6L5hOMOtNet3N08Zi-SQf7zv2EJt30SdO26bkLTrfxGXpi04DnD_MCfX1_udtcZdefP3zcrK8zwwsxZg1lRNbEkkLZ3AAHZQTTILRURMgiV7TWlta25lZJJRLLFMimFMI2oi4tv0CvF-8Q-h8TxLHqXDTQttpDP8WKKVFKIhhTCX31D3rbTyH950gVigrJWZkotlAm9DEGsNUQXKfDXFFSHZutlmar1Gx1arY6pNDLB_VUd9D8ifyuMgF8AWJa-e8Q_t7-j_YXmfeyPQ</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Zhang, Peixuan</creator><creator>Wu, Qian</creator><creator>Ding, Hongfan</creator><creator>Bai, Ruiqi</creator><creator>Meng, Fanting</creator><creator>Xu, Xiao</creator><creator>Chen, Minliang</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6413-5786</orcidid></search><sort><creationdate>20231001</creationdate><title>Efficacy and Safety of Pressure Therapy Alone and in Combination with Silicone in Prevention of Hypertrophic Scars: A Systematic Review with Meta-analysis of Randomized Controlled Trials</title><author>Zhang, Peixuan ; Wu, Qian ; Ding, Hongfan ; Bai, Ruiqi ; Meng, Fanting ; Xu, Xiao ; Chen, Minliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-d1206b0f078f4ce3e8c52ae5a680567481baf1bfb3f868506b28e6d955fd5b9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cicatrix, Hypertrophic - pathology</topic><topic>Cicatrix, Hypertrophic - prevention & control</topic><topic>Clinical trials</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Review</topic><topic>Silicones</topic><topic>Systematic review</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Peixuan</creatorcontrib><creatorcontrib>Wu, Qian</creatorcontrib><creatorcontrib>Ding, Hongfan</creatorcontrib><creatorcontrib>Bai, Ruiqi</creatorcontrib><creatorcontrib>Meng, Fanting</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Chen, Minliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Aesthetic plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Peixuan</au><au>Wu, Qian</au><au>Ding, Hongfan</au><au>Bai, Ruiqi</au><au>Meng, Fanting</au><au>Xu, Xiao</au><au>Chen, Minliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and Safety of Pressure Therapy Alone and in Combination with Silicone in Prevention of Hypertrophic Scars: A Systematic Review with Meta-analysis of Randomized Controlled Trials</atitle><jtitle>Aesthetic plastic surgery</jtitle><stitle>Aesth Plast Surg</stitle><addtitle>Aesthetic Plast Surg</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>47</volume><issue>5</issue><spage>2159</spage><epage>2174</epage><pages>2159-2174</pages><issn>0364-216X</issn><eissn>1432-5241</eissn><abstract>Background
At present, there are many kinds of hypertrophic scar treatment methods, among which pressure therapy and silicone therapy are very common and standard therapies, but whether they are used alone or in combination is still controversial. Therefore, the purpose of this systematic review was to compare the efficacy and safety of the combination of pressure therapy and silicone therapy (PTS) with pressure therapy alone (PT) in the treatment of hypertrophic scars to provide clinicians with information so that they can make better decisions.
Methods
Relevant randomized controlled trials (RCTs) were collected by searching PubMed, Ovid MEDLINE, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scopus, and Google Scholar databases to assess scar scores (The Vancouver Scar Scale, VSS; Visual Analog Scale, VAS) and adverse effects.
Results
We screened 1270 articles and included 6 RCTs including 228 patients. We found that height (MD = 0.15, 95%CI 0.10–0.21,
p
< 0.01) and pliability (MD = 0.35, 95%CI 0.25–0.46,
p
<0.01) had a significant difference, these two measures showed that the PTS group was superior to the PT group. Results in other aspects, such as VSS, vascularity, pigmentation, VAS, and adverse effects were similar between the two groups.
Conclusions
There was no significant difference between PTS and PT in the overall treatment efficacy of hypertrophic scars with similar VSS and adverse effects, but PTS might have potential benefits for height and pliability. Additional studies with larger sample size and sound methodological quality are needed to confirm our conclusions.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37648929</pmid><doi>10.1007/s00266-023-03591-w</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-6413-5786</orcidid></addata></record> |
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| subjects | Cicatrix, Hypertrophic - pathology Cicatrix, Hypertrophic - prevention & control Clinical trials Humans Medicine Medicine & Public Health Meta-analysis Otorhinolaryngology Plastic Surgery Randomized Controlled Trials as Topic Review Silicones Systematic review Treatment Outcome |
| title | Efficacy and Safety of Pressure Therapy Alone and in Combination with Silicone in Prevention of Hypertrophic Scars: A Systematic Review with Meta-analysis of Randomized Controlled Trials |
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