Chloroprocaine antagonizes progression of breast cancer by regulating LINC00494/miR‐3619‐5p/MED19 axis

Breast cancer, as the most prevalent female malignancy, leads the cancer‐related death in women worldwide. Local anesthetic chloroprocaine exhibits antitumor potential, but its specific functions and underlying molecular mechanisms in breast cancer remain unclear. Here, we demonstrated chloroprocain...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2024-01, Vol.38 (1), p.e23524-n/a
Hauptverfasser:	Chen, Chen, Wang, Ning, Huang, Tingting, Cheng, Gao, Hu, Yuexia, Wang, Bingjie, Zhang, Ye, Wang, Chunhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - pharmacology Animals Apoptosis Breast cancer Breast Neoplasms - metabolism Cancer therapies Cell Line, Tumor Cell Movement Cell Proliferation chloroprocaine Female Gene Expression Regulation, Neoplastic Humans LINC00494 Malignancy MED19 Mediator Complex - genetics Mediator Complex - metabolism Metastases Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miR‐3619‐5p Molecular modelling Procaine - analogs & derivatives Signal transduction
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