Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury

Extracellular histones induce endothelial damage, resulting in lung haemorrhage; however, the underlying mechanism remains unclear. Factor XIII, as a Ca2+-dependent cross-linking enzyme in blood, mediates fibrin deposition. As another isozyme, transglutaminase 2 (TG2) has a catalytic activity distri...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-10, Vol.678, p.179-185
Hauptverfasser:	Mizuno, Tomohiro, Nagano, Fumihiko, Ito, Yoshimasa, Tatsukawa, Hideki, Shinoda, Yoshiki, Takeuchi, Taishu, Takahashi, Kazuo, Tsuboi, Naotake, Nagamatsu, Tadashi, Yamada, Shuhei, Maruyama, Shoichi, Hitomi, Kiyotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury CD41 Extracellular histone Fibrin Platelet Transglutaminase
Online-Zugang:	Volltext
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