Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia and the tumors response to it plays an important role in determining the efficacy of antiangiogenic therapy while the connection between them remains unclear. H...

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Veröffentlicht in:	Autophagy 2024-01, Vol.20 (1), p.114-130
Hauptverfasser:	Li, Weihao, Zhou, Chi, Yu, Long, Hou, Zhenlin, Liu, Huashan, Kong, Lingheng, Xu, Yanbo, He, Jiahua, Lan, Jin, Ou, Qingjian, Fang, Yujing, Lu, Zhenhai, Wu, Xiaojun, Pan, Zhizhong, Peng, Jianhong, Lin, Junzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiangiogenesis autophagy colorectal cancer histone lactylation hypoxia Research Paper
Online-Zugang:	Volltext
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