Tazemetostat synergistically combats multidrug resistance by the unique triple inhibition of ABCB1, ABCC1, and ABCG2 efflux transporters in vitro and ex vivo

[Display omitted] ATP-binding cassette (ABC) drug efflux transporters and drug metabolizing enzymes play crucial roles in pharmacokinetic drug-drug interactions and multidrug tumor resistance (MDR). Tazemetostat (EPZ-6438, Tazverik) is a novel epigenetic drug that has been recently approved for the...

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Veröffentlicht in:	Biochemical pharmacology 2023-10, Vol.216, p.115769-115769, Article 115769
Hauptverfasser:	Budagaga, Youssif, Sabet, Ziba, Zhang, Yu, Novotná, Eva, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Cytochrome P450 Drug-drug interaction Multidrug resistance Non-small cell lung cancer Tazemetostat
Online-Zugang:	Volltext
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