Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy

Mitochondria dynamically change their morphology via fusion and fission, a process called mitochondrial dynamics. Dysregulated mitochondrial dynamics respond rapidly to metabolic cues, and are linked to the initiation and progression of diverse human cancers. Metabolic adaptations significantly cont...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-10, Vol.166, p.115342-115342, Article 115342
Hauptverfasser:	Guo, Yongjian, Luo, Chengju, Sun, Yuening, Guo, Wenjing, Zhang, Ruitian, Zhang, Xin, Ke, Xue, Wei, Libin
Format:	Artikel
Sprache:	eng
Schlagworte:	Glucose restriction Mitochondrial fusion Mitochondrial metabolic plasticity Oroxylin A
Online-Zugang:	Volltext
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