Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice

Durable reconstitution of the distal lung epithelium with pluripotent stem cell (PSC) derivatives, if realized, would represent a promising therapy for diseases that result from alveolar damage. Here, we differentiate murine PSCs into self-renewing lung epithelial progenitors able to engraft into th...

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Veröffentlicht in:	Cell stem cell 2023-09, Vol.30 (9), p.1217-1234.e7
Hauptverfasser:	Herriges, Michael J., Yampolskaya, Maria, Thapa, Bibek R., Lindstrom-Vautrin, Jonathan, Wang, Feiya, Huang, Jessie, Na, Cheng-Lun, Ma, Liang, Montminy, McKenna M., Bawa, Pushpinder, Villacorta-Martin, Carlos, Mehta, Pankaj, Kotton, Darrell N.
Format:	Artikel
Sprache:	eng
Schlagworte:	alveolar epithelium Animals bleomycin injury Cell Differentiation Cell- and Tissue-Based Therapy directed differentiation distal lung bud tip cells Epithelial Cells Epithelium lung lung progenitors Mice Pluripotent Stem Cells stem cells
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