KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

The KRASG12D mutation is present in nearly half of pancreatic adenocarcinomas (PDAC). We investigated the effects of inhibiting the KRASG12D mutant protein with MRTX1133, a non-covalent small molecule inhibitor of KRASG12D, on early and advanced PDAC and its influence on the tumor microenvironment....

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Veröffentlicht in:	Cancer cell 2023-09, Vol.41 (9), p.1606-1620.e8
Hauptverfasser:	Mahadevan, Krishnan K., McAndrews, Kathleen M., LeBleu, Valerie S., Yang, Sujuan, Lyu, Hengyu, Li, Bingrui, Sockwell, Amari M., Kirtley, Michelle L., Morse, Sami J., Moreno Diaz, Barbara A., Kim, Michael P., Feng, Ningping, Lopez, Anastasia M., Guerrero, Paola A., Paradiso, Francesca, Sugimoto, Hikaru, Arian, Kent A., Ying, Haoqiang, Barekatain, Yasaman, Sthanam, Lakshmi Kavitha, Kelly, Patience J., Maitra, Anirban, Heffernan, Timothy P., Kalluri, Raghu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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