DASH vs. Mediterranean diet on a salt restriction background in adults with high normal blood pressure or grade 1 hypertension: A randomized controlled trial
Non-pharmacological measures are recommended as the first-line treatment for individuals with high-normal blood pressure (BP) or mild hypertension. Studies directly comparing the BP effects of the Dietary Approaches to Stop Hypertension (DASH) vs. the Mediterranean diet (MedDiet) on a salt restricti...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2023-10, Vol.42 (10), p.1807-1816 |
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| creator | Filippou, Christina Thomopoulos, Costas Konstantinidis, Dimitrios Siafi, Eirini Tatakis, Fotis Manta, Eleni Drogkaris, Sotiris Polyzos, Dimitrios Kyriazopoulos, Konstantinos Grigoriou, Kalliopi Tousoulis, Dimitrios Tsioufis, Konstantinos |
| description | Non-pharmacological measures are recommended as the first-line treatment for individuals with high-normal blood pressure (BP) or mild hypertension. Studies directly comparing the BP effects of the Dietary Approaches to Stop Hypertension (DASH) vs. the Mediterranean diet (MedDiet) on a salt restriction background are currently lacking. Thus, our purpose was to assess the BP effects of a 3-month intensive dietary intervention implementing salt restriction either alone or in the context of the DASH, and the MedDiet compared to no/minimal intervention in adults with high normal BP or grade 1 hypertension.
We randomly assigned never drug-treated individuals to a control group (CG, n = 60), a salt restriction group (SRG, n = 60), a DASH diet with salt restriction group (DDG, n = 60), or a MedDiet with salt restriction group (MDG, n = 60). The primary outcome was the attained office systolic BP difference among the randomized arms during follow-up.
A total of 240 patients were enrolled, while 204 (85%) completed the study. According to the intention-to-treat analysis, compared to the CG, office and 24 h ambulatory systolic and diastolic BP were reduced in all intervention groups. A greater reduction in the mean office systolic BP was observed in the MDG compared to all other study groups (MDG vs. CG: mean difference = −15.1 mmHg; MDG vs. SRG: mean difference = −7.5 mmHg, and MDG vs. DDG: mean difference = −3.2 mmHg, all P-values |
| doi_str_mv | 10.1016/j.clnu.2023.08.011 |
| format | Article |
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We randomly assigned never drug-treated individuals to a control group (CG, n = 60), a salt restriction group (SRG, n = 60), a DASH diet with salt restriction group (DDG, n = 60), or a MedDiet with salt restriction group (MDG, n = 60). The primary outcome was the attained office systolic BP difference among the randomized arms during follow-up.
A total of 240 patients were enrolled, while 204 (85%) completed the study. According to the intention-to-treat analysis, compared to the CG, office and 24 h ambulatory systolic and diastolic BP were reduced in all intervention groups. A greater reduction in the mean office systolic BP was observed in the MDG compared to all other study groups (MDG vs. CG: mean difference = −15.1 mmHg; MDG vs. SRG: mean difference = −7.5 mmHg, and MDG vs. DDG: mean difference = −3.2 mmHg, all P-values <0.001). The DDG and the MDG did not differ concerning the office diastolic BP and the 24 h ambulatory systolic and diastolic BP; however, both diets were more efficient in BP-lowering compared to the SRG.
On a background of salt restriction, the MedDiet was superior in office systolic BP-lowering, but the DASH and MedDiet reduced BP to an extent higher than salt restriction alone.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2023.08.011</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Blood pressure ; Dietary approaches to stop hypertension diet ; Dietary intervention ; Hypertension ; Mediterranean diet ; Salt restriction</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2023-10, Vol.42 (10), p.1807-1816</ispartof><rights>2023 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-a9ce113bf960dfae86393ff09c08340c472d0fcb7dac88e264af1342e1da1f243</citedby><cites>FETCH-LOGICAL-c333t-a9ce113bf960dfae86393ff09c08340c472d0fcb7dac88e264af1342e1da1f243</cites><orcidid>0000-0002-8491-6029 ; 0000-0002-3696-4106 ; 0000-0003-1890-3139 ; 0000-0003-4697-484X ; 0000-0002-9164-4172 ; 0000-0002-5190-550X ; 0000-0002-8843-6401</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2023.08.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids></links><search><creatorcontrib>Filippou, Christina</creatorcontrib><creatorcontrib>Thomopoulos, Costas</creatorcontrib><creatorcontrib>Konstantinidis, Dimitrios</creatorcontrib><creatorcontrib>Siafi, Eirini</creatorcontrib><creatorcontrib>Tatakis, Fotis</creatorcontrib><creatorcontrib>Manta, Eleni</creatorcontrib><creatorcontrib>Drogkaris, Sotiris</creatorcontrib><creatorcontrib>Polyzos, Dimitrios</creatorcontrib><creatorcontrib>Kyriazopoulos, Konstantinos</creatorcontrib><creatorcontrib>Grigoriou, Kalliopi</creatorcontrib><creatorcontrib>Tousoulis, Dimitrios</creatorcontrib><creatorcontrib>Tsioufis, Konstantinos</creatorcontrib><title>DASH vs. Mediterranean diet on a salt restriction background in adults with high normal blood pressure or grade 1 hypertension: A randomized controlled trial</title><title>Clinical nutrition (Edinburgh, Scotland)</title><description>Non-pharmacological measures are recommended as the first-line treatment for individuals with high-normal blood pressure (BP) or mild hypertension. Studies directly comparing the BP effects of the Dietary Approaches to Stop Hypertension (DASH) vs. the Mediterranean diet (MedDiet) on a salt restriction background are currently lacking. Thus, our purpose was to assess the BP effects of a 3-month intensive dietary intervention implementing salt restriction either alone or in the context of the DASH, and the MedDiet compared to no/minimal intervention in adults with high normal BP or grade 1 hypertension.
We randomly assigned never drug-treated individuals to a control group (CG, n = 60), a salt restriction group (SRG, n = 60), a DASH diet with salt restriction group (DDG, n = 60), or a MedDiet with salt restriction group (MDG, n = 60). The primary outcome was the attained office systolic BP difference among the randomized arms during follow-up.
A total of 240 patients were enrolled, while 204 (85%) completed the study. According to the intention-to-treat analysis, compared to the CG, office and 24 h ambulatory systolic and diastolic BP were reduced in all intervention groups. A greater reduction in the mean office systolic BP was observed in the MDG compared to all other study groups (MDG vs. CG: mean difference = −15.1 mmHg; MDG vs. SRG: mean difference = −7.5 mmHg, and MDG vs. DDG: mean difference = −3.2 mmHg, all P-values <0.001). The DDG and the MDG did not differ concerning the office diastolic BP and the 24 h ambulatory systolic and diastolic BP; however, both diets were more efficient in BP-lowering compared to the SRG.
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Studies directly comparing the BP effects of the Dietary Approaches to Stop Hypertension (DASH) vs. the Mediterranean diet (MedDiet) on a salt restriction background are currently lacking. Thus, our purpose was to assess the BP effects of a 3-month intensive dietary intervention implementing salt restriction either alone or in the context of the DASH, and the MedDiet compared to no/minimal intervention in adults with high normal BP or grade 1 hypertension.
We randomly assigned never drug-treated individuals to a control group (CG, n = 60), a salt restriction group (SRG, n = 60), a DASH diet with salt restriction group (DDG, n = 60), or a MedDiet with salt restriction group (MDG, n = 60). The primary outcome was the attained office systolic BP difference among the randomized arms during follow-up.
A total of 240 patients were enrolled, while 204 (85%) completed the study. According to the intention-to-treat analysis, compared to the CG, office and 24 h ambulatory systolic and diastolic BP were reduced in all intervention groups. A greater reduction in the mean office systolic BP was observed in the MDG compared to all other study groups (MDG vs. CG: mean difference = −15.1 mmHg; MDG vs. SRG: mean difference = −7.5 mmHg, and MDG vs. DDG: mean difference = −3.2 mmHg, all P-values <0.001). The DDG and the MDG did not differ concerning the office diastolic BP and the 24 h ambulatory systolic and diastolic BP; however, both diets were more efficient in BP-lowering compared to the SRG.
On a background of salt restriction, the MedDiet was superior in office systolic BP-lowering, but the DASH and MedDiet reduced BP to an extent higher than salt restriction alone.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.clnu.2023.08.011</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8491-6029</orcidid><orcidid>https://orcid.org/0000-0002-3696-4106</orcidid><orcidid>https://orcid.org/0000-0003-1890-3139</orcidid><orcidid>https://orcid.org/0000-0003-4697-484X</orcidid><orcidid>https://orcid.org/0000-0002-9164-4172</orcidid><orcidid>https://orcid.org/0000-0002-5190-550X</orcidid><orcidid>https://orcid.org/0000-0002-8843-6401</orcidid></addata></record> |
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| ispartof | Clinical nutrition (Edinburgh, Scotland), 2023-10, Vol.42 (10), p.1807-1816 |
| issn | 0261-5614 1532-1983 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings |
| subjects | Blood pressure Dietary approaches to stop hypertension diet Dietary intervention Hypertension Mediterranean diet Salt restriction |
| title | DASH vs. Mediterranean diet on a salt restriction background in adults with high normal blood pressure or grade 1 hypertension: A randomized controlled trial |
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