Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9

DHX9 is a DExH-box RNA helicase that utilizes hydrolysis of all four nucleotide triphosphates (NTPs) to power cycles of 3' to 5' directional movement to resolve and/or unwind double stranded RNA, DNA, and RNA/DNA hybrids, R-loops, triplex-DNA and G-quadraplexes. DHX9 activity is important...

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Veröffentlicht in:	SLAS discovery 2023-12, Vol.28 (8), p.376-384
Hauptverfasser:	Gotur, Deepali, Case, April, Liu, Julie, Sickmier, E Allen, Holt, Nicholas, Knockenhauer, Kevin E, Yao, Shihua, Lee, Young-Tae, Copeland, Robert A, Buker, Shane M, Boriack-Sjodin, P Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cats Crystallography DEAD-box RNA Helicases - chemistry DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism DNA - chemistry Humans RNA, Double-Stranded
Online-Zugang:	Volltext
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