Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience
Purpose Soft tissue sarcomas are rare malignant tumors. Liposarcoma constitutes the most frequent histological subtype of retroperitoneal sarcoma. The prognosis of soft tissue sarcomas depends on clinical and histologic characteristics. Objective Evaluate variables that may be related to the overall...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2023-10, Vol.53 (10), p.1181-1187 |
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| creator | Teixeira, Frederico Ribeiro Arakaki, Mariana Sousa Lima, Helber Vidal Gadelha Ferreira, Fabio de Oliveira Menegozzo, Carlos Augusto Metidieri Silva, Eduardo Rissi Montero, Edna Frasson de Souza Oya, Toshiko Lima, Luiz Calima Akaishi, Eduardo Hiroshi Utiyama, Edivaldo Massazo |
| description | Purpose
Soft tissue sarcomas are rare malignant tumors. Liposarcoma constitutes the most frequent histological subtype of retroperitoneal sarcoma. The prognosis of soft tissue sarcomas depends on clinical and histologic characteristics.
Objective
Evaluate variables that may be related to the overall and local recurrence-free survival in patients with retroperitoneal liposarcoma and discuss the need for visceral resection en-bloc for tumors.
Methods
A retrospective analysis was conducted of the medical records of 60 patients seen between 1997 and 2017 who underwent surgical resection of retroperitoneal liposarcoma.
Results
The overall survival rate at 5 years of follow-up was 75.22% (95% confidence interval [CI] 0.58–0.86). The probability of a local recurrence-free survival at 5 years of follow-up was 26.04% (95% CI 0.11–0.44). The multivariate analysis showed that dedifferentiated or pleomorphic tumors and R2/fragmented resection were associated with a shorter time to recurrence. No other characteristics markedly influenced the overall survival (
P
> 0.05).
Conclusion
Patients with dedifferentiated or pleomorphic tumors and incomplete resection were associated with higher local recurrence rates than others. This study reinforces the need for complete and en-bloc resection with organs when there is clear involvement or technical surgical difficulty to maintain the tumor integrity. |
| doi_str_mv | 10.1007/s00595-023-02731-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2854968672</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2854968672</sourcerecordid><originalsourceid>FETCH-LOGICAL-c299t-f7c40dbf60590412cb6aff7b8d32d5b7e9157b2c89a2c78b86708c1a6f62d5b43</originalsourceid><addsrcrecordid>eNp9UMtOAyEUJUYTa_UHXLF0gwLzgFmZpvGV1LjRNWHopdJMhxEYtX8vdVy7uLn35jyScxC6ZPSaUSpuIqVVUxHKizyiYEQeoRkri5pwyYpjNKNNyQjjDTtFZzFuKeWlpHSGts9jl9yniwaC7nCACCY532PrQ_5S8AMEl3wPGe3c4KMOxu80cRG7hL98SO_5uMULzCnZgw44un7TATHQJwgYvg8G0Bs4RydWdxEu_vYcvd3fvS4fyerl4Wm5WBHDmyYRK0xJ162tcyJaMm7aWlsrWrku-LpqBTSsEi03stHcCNnKWlBpmK5tfcDLYo6uJt8h-I8RYlK7Q7yu0z34MSouq7Kps4xnKp-oJvgYA1g1BLfTYa8YVYdi1VSsysWq32KVzKJiEsVM7jcQ1NaPoc-R_lP9ALGDfTU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2854968672</pqid></control><display><type>article</type><title>Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience</title><source>SpringerLink Journals - AutoHoldings</source><creator>Teixeira, Frederico Ribeiro ; Arakaki, Mariana Sousa ; Lima, Helber Vidal Gadelha ; Ferreira, Fabio de Oliveira ; Menegozzo, Carlos Augusto Metidieri ; Silva, Eduardo Rissi ; Montero, Edna Frasson de Souza ; Oya, Toshiko ; Lima, Luiz Calima ; Akaishi, Eduardo Hiroshi ; Utiyama, Edivaldo Massazo</creator><creatorcontrib>Teixeira, Frederico Ribeiro ; Arakaki, Mariana Sousa ; Lima, Helber Vidal Gadelha ; Ferreira, Fabio de Oliveira ; Menegozzo, Carlos Augusto Metidieri ; Silva, Eduardo Rissi ; Montero, Edna Frasson de Souza ; Oya, Toshiko ; Lima, Luiz Calima ; Akaishi, Eduardo Hiroshi ; Utiyama, Edivaldo Massazo</creatorcontrib><description>Purpose
Soft tissue sarcomas are rare malignant tumors. Liposarcoma constitutes the most frequent histological subtype of retroperitoneal sarcoma. The prognosis of soft tissue sarcomas depends on clinical and histologic characteristics.
Objective
Evaluate variables that may be related to the overall and local recurrence-free survival in patients with retroperitoneal liposarcoma and discuss the need for visceral resection en-bloc for tumors.
Methods
A retrospective analysis was conducted of the medical records of 60 patients seen between 1997 and 2017 who underwent surgical resection of retroperitoneal liposarcoma.
Results
The overall survival rate at 5 years of follow-up was 75.22% (95% confidence interval [CI] 0.58–0.86). The probability of a local recurrence-free survival at 5 years of follow-up was 26.04% (95% CI 0.11–0.44). The multivariate analysis showed that dedifferentiated or pleomorphic tumors and R2/fragmented resection were associated with a shorter time to recurrence. No other characteristics markedly influenced the overall survival (
P
> 0.05).
Conclusion
Patients with dedifferentiated or pleomorphic tumors and incomplete resection were associated with higher local recurrence rates than others. This study reinforces the need for complete and en-bloc resection with organs when there is clear involvement or technical surgical difficulty to maintain the tumor integrity.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-023-02731-8</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Medicine ; Medicine & Public Health ; Original Article ; Surgery ; Surgical Oncology</subject><ispartof>Surgery today (Tokyo, Japan), 2023-10, Vol.53 (10), p.1181-1187</ispartof><rights>The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c299t-f7c40dbf60590412cb6aff7b8d32d5b7e9157b2c89a2c78b86708c1a6f62d5b43</cites><orcidid>0000-0002-2333-2898</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-023-02731-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-023-02731-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Teixeira, Frederico Ribeiro</creatorcontrib><creatorcontrib>Arakaki, Mariana Sousa</creatorcontrib><creatorcontrib>Lima, Helber Vidal Gadelha</creatorcontrib><creatorcontrib>Ferreira, Fabio de Oliveira</creatorcontrib><creatorcontrib>Menegozzo, Carlos Augusto Metidieri</creatorcontrib><creatorcontrib>Silva, Eduardo Rissi</creatorcontrib><creatorcontrib>Montero, Edna Frasson de Souza</creatorcontrib><creatorcontrib>Oya, Toshiko</creatorcontrib><creatorcontrib>Lima, Luiz Calima</creatorcontrib><creatorcontrib>Akaishi, Eduardo Hiroshi</creatorcontrib><creatorcontrib>Utiyama, Edivaldo Massazo</creatorcontrib><title>Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><description>Purpose
Soft tissue sarcomas are rare malignant tumors. Liposarcoma constitutes the most frequent histological subtype of retroperitoneal sarcoma. The prognosis of soft tissue sarcomas depends on clinical and histologic characteristics.
Objective
Evaluate variables that may be related to the overall and local recurrence-free survival in patients with retroperitoneal liposarcoma and discuss the need for visceral resection en-bloc for tumors.
Methods
A retrospective analysis was conducted of the medical records of 60 patients seen between 1997 and 2017 who underwent surgical resection of retroperitoneal liposarcoma.
Results
The overall survival rate at 5 years of follow-up was 75.22% (95% confidence interval [CI] 0.58–0.86). The probability of a local recurrence-free survival at 5 years of follow-up was 26.04% (95% CI 0.11–0.44). The multivariate analysis showed that dedifferentiated or pleomorphic tumors and R2/fragmented resection were associated with a shorter time to recurrence. No other characteristics markedly influenced the overall survival (
P
> 0.05).
Conclusion
Patients with dedifferentiated or pleomorphic tumors and incomplete resection were associated with higher local recurrence rates than others. This study reinforces the need for complete and en-bloc resection with organs when there is clear involvement or technical surgical difficulty to maintain the tumor integrity.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOAyEUJUYTa_UHXLF0gwLzgFmZpvGV1LjRNWHopdJMhxEYtX8vdVy7uLn35jyScxC6ZPSaUSpuIqVVUxHKizyiYEQeoRkri5pwyYpjNKNNyQjjDTtFZzFuKeWlpHSGts9jl9yniwaC7nCACCY532PrQ_5S8AMEl3wPGe3c4KMOxu80cRG7hL98SO_5uMULzCnZgw44un7TATHQJwgYvg8G0Bs4RydWdxEu_vYcvd3fvS4fyerl4Wm5WBHDmyYRK0xJ162tcyJaMm7aWlsrWrku-LpqBTSsEi03stHcCNnKWlBpmK5tfcDLYo6uJt8h-I8RYlK7Q7yu0z34MSouq7Kps4xnKp-oJvgYA1g1BLfTYa8YVYdi1VSsysWq32KVzKJiEsVM7jcQ1NaPoc-R_lP9ALGDfTU</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Teixeira, Frederico Ribeiro</creator><creator>Arakaki, Mariana Sousa</creator><creator>Lima, Helber Vidal Gadelha</creator><creator>Ferreira, Fabio de Oliveira</creator><creator>Menegozzo, Carlos Augusto Metidieri</creator><creator>Silva, Eduardo Rissi</creator><creator>Montero, Edna Frasson de Souza</creator><creator>Oya, Toshiko</creator><creator>Lima, Luiz Calima</creator><creator>Akaishi, Eduardo Hiroshi</creator><creator>Utiyama, Edivaldo Massazo</creator><general>Springer Nature Singapore</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2333-2898</orcidid></search><sort><creationdate>20231001</creationdate><title>Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience</title><author>Teixeira, Frederico Ribeiro ; Arakaki, Mariana Sousa ; Lima, Helber Vidal Gadelha ; Ferreira, Fabio de Oliveira ; Menegozzo, Carlos Augusto Metidieri ; Silva, Eduardo Rissi ; Montero, Edna Frasson de Souza ; Oya, Toshiko ; Lima, Luiz Calima ; Akaishi, Eduardo Hiroshi ; Utiyama, Edivaldo Massazo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-f7c40dbf60590412cb6aff7b8d32d5b7e9157b2c89a2c78b86708c1a6f62d5b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teixeira, Frederico Ribeiro</creatorcontrib><creatorcontrib>Arakaki, Mariana Sousa</creatorcontrib><creatorcontrib>Lima, Helber Vidal Gadelha</creatorcontrib><creatorcontrib>Ferreira, Fabio de Oliveira</creatorcontrib><creatorcontrib>Menegozzo, Carlos Augusto Metidieri</creatorcontrib><creatorcontrib>Silva, Eduardo Rissi</creatorcontrib><creatorcontrib>Montero, Edna Frasson de Souza</creatorcontrib><creatorcontrib>Oya, Toshiko</creatorcontrib><creatorcontrib>Lima, Luiz Calima</creatorcontrib><creatorcontrib>Akaishi, Eduardo Hiroshi</creatorcontrib><creatorcontrib>Utiyama, Edivaldo Massazo</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teixeira, Frederico Ribeiro</au><au>Arakaki, Mariana Sousa</au><au>Lima, Helber Vidal Gadelha</au><au>Ferreira, Fabio de Oliveira</au><au>Menegozzo, Carlos Augusto Metidieri</au><au>Silva, Eduardo Rissi</au><au>Montero, Edna Frasson de Souza</au><au>Oya, Toshiko</au><au>Lima, Luiz Calima</au><au>Akaishi, Eduardo Hiroshi</au><au>Utiyama, Edivaldo Massazo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><date>2023-10-01</date><risdate>2023</risdate><volume>53</volume><issue>10</issue><spage>1181</spage><epage>1187</epage><pages>1181-1187</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
Soft tissue sarcomas are rare malignant tumors. Liposarcoma constitutes the most frequent histological subtype of retroperitoneal sarcoma. The prognosis of soft tissue sarcomas depends on clinical and histologic characteristics.
Objective
Evaluate variables that may be related to the overall and local recurrence-free survival in patients with retroperitoneal liposarcoma and discuss the need for visceral resection en-bloc for tumors.
Methods
A retrospective analysis was conducted of the medical records of 60 patients seen between 1997 and 2017 who underwent surgical resection of retroperitoneal liposarcoma.
Results
The overall survival rate at 5 years of follow-up was 75.22% (95% confidence interval [CI] 0.58–0.86). The probability of a local recurrence-free survival at 5 years of follow-up was 26.04% (95% CI 0.11–0.44). The multivariate analysis showed that dedifferentiated or pleomorphic tumors and R2/fragmented resection were associated with a shorter time to recurrence. No other characteristics markedly influenced the overall survival (
P
> 0.05).
Conclusion
Patients with dedifferentiated or pleomorphic tumors and incomplete resection were associated with higher local recurrence rates than others. This study reinforces the need for complete and en-bloc resection with organs when there is clear involvement or technical surgical difficulty to maintain the tumor integrity.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><doi>10.1007/s00595-023-02731-8</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2333-2898</orcidid></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Medicine Medicine & Public Health Original Article Surgery Surgical Oncology |
| title | Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience |
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