Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers

Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids, phospholipids, cholesterol, and PEG-conjugated lipids, assembled by microfluidic or T-tube, are the benchmark synthetic vector for...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-08, Vol.145 (34), p.18760-18766
Hauptverfasser:	Lu, Juncheng, Atochina-Vasserman, Elena N., Maurya, Devendra S., Sahoo, Dipankar, Ona, Nathan, Reagan, Erin K., Ni, Houping, Weissman, Drew, Percec, Virgil
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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