Real-time influence of intracellular acidification and Na + /H + exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31 P-NMR and hyperpolarized 13 C-NMR study

Disruption of acid-base balance is linked to various diseases and conditions. In the heart, intracellular acidification is associated with heart failure, maladaptive cardiac hypertrophy, and myocardial ischemia. Previously, we have reported that the ratio of the in-cell lactate dehydrogenase (LDH) t...

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Veröffentlicht in:	NMR in biomedicine 2023-10, Vol.36 (10), p.e4993
Hauptverfasser:	Shaul, David, Lev-Cohain, Naama, Sapir, Gal, Sosna, Jacob, Gomori, J Moshe, Joskowicz, Leo, Katz-Brull, Rachel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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