No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children
Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically deve...
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| Veröffentlicht in: | Journal of autism and developmental disorders 2024-05, Vol.54 (5), p.1947-1960 |
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| container_issue | 5 |
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| container_title | Journal of autism and developmental disorders |
| container_volume | 54 |
| creator | Ahlfors, Seppo P. Graham, Steven Bharadwaj, Hari Mamashli, Fahimeh Khan, Sheraz Joseph, Robert M. Losh, Ainsley Pawlyszyn, Stephanie McGuiggan, Nicole M. Vangel, Mark Hämäläinen, Matti S. Kenet, Tal |
| description | Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6–17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported. |
| doi_str_mv | 10.1007/s10803-023-05907-w |
| format | Article |
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Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6–17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. 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Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported.</description><subject>Acoustic Stimulation - methods</subject><subject>Adolescent</subject><subject>Auditory Perception - physiology</subject><subject>Auditory processing</subject><subject>Auditory stimuli</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - physiopathology</subject><subject>Autistic children</subject><subject>Behavioral Science and Psychology</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Child</subject><subject>Child and School Psychology</subject><subject>Children</subject><subject>Coherence</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Female</subject><subject>Hearing</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Information processing</subject><subject>Magnetoencephalography</subject><subject>Magnetoencephalography - methods</subject><subject>Male</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Pediatrics</subject><subject>Psychology</subject><subject>Public Health</subject><subject>Sensory integration</subject><subject>Sensory perception</subject><subject>Sensory processes</subject><subject>Stimulation</subject><issn>0162-3257</issn><issn>1573-3432</issn><issn>1573-3432</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNp9kcFu1DAURS0EotPCD7BAltiwCX224zhZVlOgSBVIzOwtj_PSukriYDsdZcG_Y5pSJBYsLC987n3POoS8YfCBAajzyKAGUQDPRzagiuMzsmFSiUKUgj8nG2AVLwSX6oScxngHAE3N-UtyIqpGcK5gQ35-9fTSdR0GHC1G6kZ6Mbcu-bDQXULTLsUumYT0O8bJj3FFtreub3OCHl26zYHk4kB3E9oU5iH3RR9aDNSMLd0vk7Om7xd6iffY-8mNN0_5V-RFZ_qIrx_vM7L_9HG_vSquv33-sr24LqzgVSoEK2VXKn5Q3cGIipn826ZmqkQjobLNoWtaARXItpEgpeSqVlJg2VnZtcyKM_J-rZ2C_zFjTHpw0WLfmxH9HDWvZVkKVsk6o-_-Qe_8HMa8nM4TmJQVcMgUXykbfIwBOz0FN5iwaAb6txu9utHZjX5wo4859Paxej4M2D5F_sjIgFiBmJ_GGwx_Z_-n9hcxM5pN</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Ahlfors, Seppo P.</creator><creator>Graham, Steven</creator><creator>Bharadwaj, Hari</creator><creator>Mamashli, Fahimeh</creator><creator>Khan, Sheraz</creator><creator>Joseph, Robert M.</creator><creator>Losh, Ainsley</creator><creator>Pawlyszyn, Stephanie</creator><creator>McGuiggan, Nicole M.</creator><creator>Vangel, Mark</creator><creator>Hämäläinen, Matti S.</creator><creator>Kenet, Tal</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7674-6931</orcidid></search><sort><creationdate>20240501</creationdate><title>No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children</title><author>Ahlfors, Seppo P. ; 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| subjects | Acoustic Stimulation - methods Adolescent Auditory Perception - physiology Auditory processing Auditory stimuli Autism Autism Spectrum Disorder - physiopathology Autistic children Behavioral Science and Psychology Biological markers Biomarkers Child Child and School Psychology Children Coherence Evoked Potentials, Auditory - physiology Female Hearing Humans Hypotheses Information processing Magnetoencephalography Magnetoencephalography - methods Male Neurosciences Original Paper Pediatrics Psychology Public Health Sensory integration Sensory perception Sensory processes Stimulation |
| title | No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children |
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